What is Gabapentin? When is this medication prescribed to be used?

The unpatented name of Gabapentin is Neurontin. Thus, Gabapentin is nothing more than a registered trademark for a medication that can be made by different manufacturers but under other names. It is so because the active agent was discovered a while ago and therefore is no longer protected by the know-how.

Neurontin by Intas Pharmaceuticals Ltd. is a pharmaceutical product, an anticonvulsant / antiepileptic medication utilized both for epilepsy treatment and neuropathic pain so if you have such diagnoses, you can buy Neurontin online right on this web page but it would be much better if you first ask your physician if the medication is suitable for you. It is similar to GABA (gamma-aminobutyric acid) but its effect isn’t related to the direct impact on GABA receptors.

How does Neurontin act?

The formulation has a structural similarity to GABA which is a neurotransmitter but it doesn’t change the radioligand binding of GABA to GABA receptors. It also isn’t metabolized into GABA or antagonist of GABA receptors and doesn’t inhibit or disrupt GABA dissimilation.

Neurontin also doesn’t bind with the receptors engaged in the action of other preparations or neurotransmitters of the brain including receptors for benzodiazepines, glutamate, glycine or N-methyl-D-aspartate.

During the trials, it was noted that the formulation interacts with sodium channels which distinguish it from Phenytoin and Carbamazepine. It also slightly lowers the production of monoamine neurotransmitters.

During the trials on animals, it had been discovered that the medication elevates the exchange of GABA in some areas of the brain which is typical for Valproate sodium, but for other parts of the brain. Although the value of these actions of Gabapentin in relation to anticonvulsant action has not yet been established, it is proven that it has a potent anti-seizure activity. In animals, it rapidly penetrates the brain and prevents convulsions caused by maximum electric shock, chemical consultants, including inhibitors of GABA synthesis.

During all of the clinical studies of the medication in people for the prevention of secondary generalized tonic-clonic convulsions, the medication had shown statistically significant results and positive tendencies practically in all patients included in the tests. So if you are diagnosed with the type of seizures for which the medication is the most effective, your healthcare provider can order you to buy Generic Neurontin and either add to your other therapy or as a replacement of other medication that you use.

The medication is not significantly transformed or dissimilated in the body. The amount of the active substance in the body is proportionally lowered depending on the dosage – the higher is the dose, the lower is the bioavailability (the amount of the substance active within the body). The intake of the pills with food renders a mild effect on the speed and degree of absorption of the preparation.

When your doctor can prescribe you Neurontin?

The therapy with the utilization of the formulation is ordered in partial epileptic seizures with or without secondary generalization as a supplementary therapy. It can be utilized for the therapy of adult patients and kids aged from three years but the dosage regimes are different. Neurontin is also sometimes used to relieve pain caused by postherpetic neuralgia in adults.

If you have these conditions and want to buy Gabapentin to treat them, you can do so but ensure that your doctor approves this therapy.

Whom is Neurontin contraindicated?

The medication use can be dangerous and therefore is contraindicated for people with hypersensitivity to its components and especially the active substance. Besides, it must not be used for the therapy of epilepsy in children aged younger than three years and younger than twelve years for postherpetic neuralgia.

Can Neurontin be used during pregnancy or lactation?

The use of the preparation during pregnancy is possible only if the expected effect is higher than the risk for the fetus. Since there hadn’t been enough fully controlled studies, the safety of the preparation for pregnant women unborn babies is unknown so the use of the medication is possible only in critical cases.

During breastfeeding, it is advised to use other anticonvulsants that do not penetrate the breast milk or to stop breastfeeding if this preparation is considered the most suitable.

Can Neurontin cause any adverse effects?

Even in people for whom the medication is not contraindicated the medication can contribute to the development of adverse effects such as dizziness, sleepiness, nausea, and angioedema. These adverse effects were the most frequent ones during the clinical trials with the use of placebo in a half of patients.

There can be also other adverse effects with the whole list of which you can get acquainted reading the medication’s package insert. Based on your other conditions, for instance, a heart disease, your doctor should instruct you on how you should act in case of specific adverse reactions occurrence to avoid allowing the medication do significant harm to your body.

Adverse Reactions in Pooled Placebo-Controlled Trials in Postherpetic Neuralgia

Adverse Reactions in Pooled Placebo-Controlled Add-On Trials In Epilepsy Patients >12 years of age

How should be Neurontin used?

Here you can find the information that is available within the package of pills on the insert instruction but you need to acknowledge that the optimal treatment plan for you can be chosen by your doctor so make sure to follow his or her order when you buy Generic Gabapentin.

The medication can be taken with or without food.

For the therapy of epilepsy, the long-duration treatment is appointed. The doses for children aged twelve and more years and adult patients are usually prescribed doses in the range from 900 mg to 3.6 grams per day. The initial dosage usually is 900 mg split into three intakes for the first day of therapy. Then, the dosage is elevated by 300 mg every two to three days till the achievement of the optimal therapeutic effect. Although this dose is standard, for some individuals a lower dosage increase or with bigger intervals is needed to ensure better tolerability of the formulation.

The interval between the medications’ intakes must not be over twelve hours to avoid any breaks in its effect against seizures.

The dosage for children aged from six to twelve years is 10-15 milligrams per kilogram, of the body mass per day. The effective dose per day for this group of patients is around 25-35 mg per kilogram per day. It should be achieved within three days after the therapy start with the gradual increase in accordance with the pediatrician’s indications.

The treatment of neuropathic pain in adults is made in the same scheme as the treatment of epilepsy but the usual treatment course duration doesn’t last more than five months. The treatment of neuropathic pain in children is not approved with this medication.

Precautions and norms for special groups of patients

Individuals with Patients with the severe advanced condition or certain receding factors, such as low body weight, organ transplant, or other serious conditions or diseases, the dosage elevation should be made more slowly or lowering the dosage by which the daily dosage is increased.

The medication must be cautiously used in individuals older than sixty-five as due to possible age-related kidney dysfunction they may need lowered dosages and slower elevation of the dosage. In this group of patients, such adverse effects as sleepiness, dizziness, and edema (swelling) are more frequent.

Individuals with pronounced kidney insufficiency or people on hemodialysis need individual dosage adjustments (the recommended form of the medication is 100 mg capsules to make a single dose smaller).

When you order Neurontin and start the therapy, it is advised to avoid driving vehicles or operating any machinery as the drug can cause sleepiness and inability to focus.

In the combined use of the formulation with morphine, it is obligatorily to pay close attention to any adverse effects from the part of the central nervous system to avoid serious damage to the health.

Gabapentin should not to be taken earlier than after 2 h after the use of antacids (medicines that lower stomach acidity). The medication also interacts with other medicines and substances including alcohol, so you must get acquainted with the list of contraindicated combinations of medicines available on the medication label. Or better inform your doctor about any medicines you use so he or she would decide whether it is safe or not to use those medicines with Neurontin.

When identifying the protein level in the urine with the Multistix SG test, false results can be obtained if Gabapentin is utilized with other anticonvulsants, so it is advised to use more specific methods.

Where can you buy Neurontin?

The cheapest and easiest way to get the pills is to order Generic Neurontin from our med store as you wouldn’t even need to leave your house to do so.

Shipping of Neurontin

The preparation is shipped all over the world. To know more about the terms and cost please visit our FAQ section or contact our managers.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section