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4RX Store > Medication List > Anti Convulsants drugs > Order Topamax online

Anti Convulsants Medication (Topamax)

 
Generic name:
Topamax
Brand name:
Topiramate
Description:
Topiramate or Topamax (a trade name) is an antiepileptic medication that can be used as a monotherapy in adults and children aged 6 and more years or as a part of combination therapy in a adults and children over 2 years of age. The formulation is also used as a preventive means for migraines.
Indications:
Epilepsy, Partial seizures, Primarily generalized seizures, Secondary generalized seizures, Lennox-Gastaut syndrome, Prevention of migraine
Benefits:
Reduces the number and frequency of seizures, prevents migraine attacks
Manufacture:
Sun Pharma
Sun Pharma
Synonyms:
Topaz, Topirol, Tipiramate
 
   
Topamax (Generic Topiramate)
 
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  Generic Medication guide:

What is the preparation called Topamax?

The medication you may know as Topamax is actually an internationally-approved medical substance Topiramate. The name Topamax is a commercial name although the same preparation can be sold under different names.
Topiramate is an antiepileptic formulation with an unusual structure – it is a fructose derivative. Unlike other antiepileptic medications, it isn’t efficient in the coping with manic states or as an antidepressive agent for bipolar disorder. It has been tested as a medication for the posttraumatic disorder, alcoholism, overeating, migraines and headaches, and neuropathy but isn’t approved yet for these conditions.

Short drug info
Trade names Lepsiral, Mysoline, Resimatil, Primaclone
Pregnancy category

AU: D

US: D (Evidence of risk)

Routes of administration Oral
Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only

Bioavailability 80%
Protein binding 13–17%; 15–41%
Metabolism Hepatic (20–30%)
Elimination half-life 19–25 hours
Excretion Urine (70–80%)

When can you start using Topamax?

Naturally, it is better to buy Topamax like any other medication when your healthcare provider orders you to do so and appoints the treatment course. Here you can find the recommendations for the formulation use excerpt from the official instruction.
Topamax is appointed for adults and kids over six years with partial seizures that can turn into generalized or remain partial and the generalized from the beginning epileptic seizures.
It can be also utilized as an additional means for kids older than two years and adults with partial seizures with or without the secondary generalization (i.e. turning into a generalized seizure) and initially generalized convulsions caused by with Lennox–Gastaut syndrome (childhood-onset epilepsy).
The formulation is also approved for the prevention of migraines (it is not as effective in acute conditions and therefore needs to be used as a preventive measure) and as an anti-obesity medication approved to be combined with weight loss preparation Phentermine.
Please note that the same conditions are treated with different medications or combinations of medications at a doctor’s discretion in accordance with your personal features, accompanying diseases, and so on. To get the maximum effect from the therapy without harming your health, you need to ask your healthcare provider if this medication is suitable for you before you buy generic Topamax.

When you shouldn’t use Topiramate?

The use of the formulation is contraindicated for individuals who are allergic or otherwise negatively sensitive to the formulation’s ingredients. It is also not advised to use the pills during pregnancy and lactation, for kids younger than two years. Besides, Topiramate is not advised for women of fertile age for the prophylaxis of migraines unless they use reliable contraception methods (preferably, barrier contraception) because the use of the medication during pregnancy is fraught with harm to the fetus.

Can the therapy with Topiramate cause any negative effects?

It’s only natural that any substance you consume can cause a negative response from your body especially if it’s a chemical compound that interacts with your body functions to lower the frequency and intensity of seizures.

In case of Topiramate the negative effects can be following:
- Increased fatigue;
- Ataxia;
- Slowed down pace of thinking and inability to focus;
- Emotional lability;
- Confusion;
- Dizziness;
- Paresthesia;
- Hypoesthesia;
- Drowsiness;

Rarely can develop also:
- Over agitation;
- Amnesia;
- Aphasia;
- Depression;
- Visual impairments;
- Conjunctivitis;
- Nystagmus;
- Speech impairment;
- Distortion of taste sensations;
- Anorexia;
- Gingivitis;
- Nausea;
- Weight loss;
- Abdominal pain;
- Chills;
- Leukopenia;
- Dyspnoea;
- Edema;
- Epistaxis;
- Nephrolithiasis;
- Hematuria;
- Pruritis;
- Tinnitus;
- Dysmenorrhea;
- Weakening of libido and impotence.
Some of these adverse effects may not be threatening for you while others require special attention. Thus, you need to talk to your doctor beforehand about how you should react in the appearance of one or another adverse effect.

Most Common Adverse Reactions in Pooled Placebo-Controlled, Add-On Epilepsy Trials in Adults

Body System Adverse Reaction
Placebo (Number of patients = 291) %
TOPAMAX Dosage (mg/day) 200-400 (Number of patients = 183) %
Fatigue
13
15
Asthenia
1
6
Back pain
4
5
Chest pain
3
4
Influenza-like symptoms
2
3
Dizziness
15
25
Ataxia
7
16
Speech disorders/Related speech problems
2
13
Paresthesia
4
11
Nystagmus
7
10
Tremor
6
9
Language problems
1
6
Coordination abnormal
2
4
Gait abnormal
1
3
Nausea
8
10
Dyspepsia
6
7
Abdominal pain
4
6
Constipation
2
4
Weight loss
3
9
Somnolence
12
29
Nervousness
6
16
Psychomotor slowing
2
13
Difficulty with memory
3
12
Anorexia
4
10
Confusion
5
11
Difficulty with concentration/attention
2
6
Mood problems
2
4
Agitation
2
3
Aggressive reaction
2
3
Emotional lability
1
3
Cognitive problems
1
3
Breast pain
2
4
Pharyngitis
2
6
Rhinitis
6
7
Sinusitis
4
5
Vision abnormal
2
13
Diplopia
5
10

 Risk by indication for antiepileptic drugs in the pooled analysis

Indication
Placebo Patients with Events per 1000 Patients
Drug Patients with Events per 1000 Patients
Epilepsy
1.0
3.4
Psychiatric
5.7
8.5
Other
1.0
1.8
Total
2.4
4.3

How does the medicine’s effect is rendered?

The action of the formulation is achieved through the blocking of the sodium channels and the occurrence of repeated action potentials on the background of long-duration depolarization of the neuron membrane. It also Increases the frequency of GABA-receptor activation, increases the GABA-induced flow of chloride ions into the neuron, and enhances the inhibitory GABAergic transmission. Prevents the activation of kainate with the kainate / AMPK subtype glutamate receptors and inhibits the exciting glutamatergic neurotransmission. The preparation also diminishes the activity of some isoenzymes of carbonic anhydrase.
After the dosage intake, the preparation is quickly absorbed from the digestive tract. It is not influenced by food and 81% of it are active within the body.

How does Topamax must be taken?

When you buy Topiramate, you should know that the therapy of any condition treated with the drug should be started with the minimum dosage with the subsequent gradual increase of it till the optimal dosage is found. The dosage increase and rate of increase should be made in accordance with the clinical response.
- Epilepsy therapy in adults is started with the use of 0.025 grams before bedtime for one week with the succeeding elevation of the dosage once a week per 0.025 or 0.05 grams taken into two intakes. If such tempo of the dosage elevation is poorly tolerable, the interval between the dosage increases can be increased. If it’s the only medication used, the optimal therapeutic dosage is 0.1-0.2 grams a day split into two intakes. The maximum dosage is 0.5 grams a day/2 intakes but in refractory forms of epilepsy, the dosages can be raised to 1 g/2 intakes a day. These instructions are valid for adults, children aged 16 and more, and elderly patients with normal kidney function.
- Children older than six years are given 0.5-1 mg per kilogram of the body weight before bedtime for one week with the following elevation of the dosage by 0.5-1 mg per kg of weight per dosage adjustment in a week or two. The recommended daily dosage that should be achieved through the increases is 100 mg a day or about 2 mg per kilogram of the body weight.
- The use of the medication as an addition to the main antiepileptic therapy in adults is also made with a gradual increase after the intake of the minimum dosage of 25 mg a day before bedtime for a week. The dosage is increased once in a week or two by 25-50 mg per increase till the achievement of the optimal response. According to the tests, the minimum effective dosage in combination therapy is 200 mg a day. The recommended dosage is 200-400 mg of Topiramate a day split into two intakes.
- Children aged from two years as an additional therapy should receive 5-9 mg per kilogram of the body weight split into two intakes. The therapy should be started with 25 mg a day or less as calculated by the formula 1-3 kg per kilogram of the weight. The dosage is increased once in a week or two by 1-3 kg per kilogram of the weight per increase till the achievement of the optimal clinical response. According to the clinical studies, the doses up to 30 mg per kg of the body weight a day are well tolerated.
- Migraine prevention requires the use of 100 mg a day split into two intakes. The therapy should be started with the use of 25 milligrams before bedtime for one week with the following elevation of the dosage by 25 milligrams once a month. If such rate of the dosage elevation is poorly tolerable, the interval between the dosage increases can be increased.  In some patients, the sufficient dosage is 50 mg a day. During the clinical studies, for this condition, the maximum daily dosage was 200 mg but it is recommended to use lower doses to avoid the occurrence of adverse effects.

Interactions of Topiramate

Before you buy generic Topiramate, you must not neglect the precautions and use it if you take any medications it is contraindicated to be used with.
For instance, it is contraindicated to use the medication with any medicines that depress the central nervous system and/or alcohol.
The use of the formulation with any medicines that predispose to nephrolithiasis may increase the risk of kidney stones formation.
Phenytoin and Carbamazepine lower the content of Topiramate in the blood.
The preparation lowers the level of Phenytoin in the blood plasma and the efficiency of oral contraceptives.

Overdose danger

The overdose of the preparation can cause the intensification of the adverse reactions. The measures to cope with that are gastric lavage and vomiting induction, supportive therapy, and hemodialysis.

Precautions

When you order Topamax with a plan to use it as a single medication for epilepsy and discontinue using other medications, you should know that you need to acknowledge the possible temporary increase of the number of epileptic attacks. If there is no need to cancel the other medications use abruptly, it is advised to gradually lower its dosage by one-third every two weeks along with the elevation of Topamax dosage. At the same time, if you want to discontinue using Topamax and instead use another formulation, you should lower the daily dosage of the drug gradually over the course of eight weeks while gradually elevating the dosage of the new medication in accordance with its label.
You should also keep in mind, or better your doctor whom you must consult about the therapy, that in the withdrawal of medications that are inducers of hepatic enzymes, the concentrations of Topiramate in the blood will raise. Hence, in the presence of clinical indications, the dosages can be reduced.
People who undergo hemodialysis on the day of the procedure should receive an additional dosage (around a half of the daily dosage) before and after the procedure.
Individuals with the high risk of nephrolithiasis (kidney stones) are recommended to make an adequate increase in the amount of fluid consumed.
Individuals with impaired liver function due to a possible decrease in the clearance of Topiramate should exert caution while using the medication.
There is a risk of the onset of secondary closed-angle glaucoma. Therefore, in any vision impairment you must inform your healthcare provider.
In case of insignificant body mass loss during the therapy with the formulation, it is advised to start consuming more calories or take supplements.
Individuals who need the ability to concentrate as they work with dangerous machinery do not need to order Topamax as one of its possible adverse effects loss of ability to focus.

Where should you buy Topamax?

The medication is sold at the regular and online drugstore. We offer you to order Topiramate cheap and with fast delivery. We sell the best quality generic medicines without Rx, so naturally, it is more beneficial to get the pills from our drugstore rather than a regular one.

Shipping of Topamax

The medication is shipped worldwide via standard and express mail.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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