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4RX Store > Medication List > Anti Depressants drugs > Order Anafranil online

Anti Depressants Medication (Anafranil)

 
Generic name:
Anafranil
Brand name:
Clomipramine HCI
Description:
Anafranil is a brand name of the medical substance Clomipramine HCI. It is a tricyclic antidepressant that also inhibits the reuptake of serotonin. The indications for the drug use are depressions of different cause and nature, including the ones related to the age or disease, chronic pain syndrome, panic disorder, agoraphobia, obsessive-compulsive disorder, and bedwetting in children older than six years.
Indications:
Depression of different cause, Major depressive disorder, Panic disorder, Chronic pain syndrome, Agoraphobia, Obsessive-compulsive disorder, Nocturnal enuresis in children (bedwetting)
Benefits:
Helps to quickly minimize the symptoms of depression and other disorders (just within 3-5 days)
Manufacture:
Sun Pharma
Sun Pharma
Synonyms:
Clonil, Tridep, Clomipraminum, Hydiphen, Monochlorimipramine
 
   
Anafranil (Generic Clomipramine HCI)
 
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  Generic Medication guide:

What is the medication marketed under the name Anafranil?

Anafranil is a commercial name of the active agent Clomipramine which is a tricyclic antidepressant similar by the action to Imipramine but more potently blocking the reuptake of serotonin. It is different from Imipramine only by the presence in the molecule of the chlorine atom. The preparation also renders alpha-blocking action (relaxation of the smooth muscle or blood vessels) and antihistamine actions.

Short drug info
Trade names Anafranil, Clomicalm, others
Pregnancy category

AU: C

US: C (Risk not determined)

Routes of administration By mouth
Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only

Bioavailability ~50%
Protein binding 96–98%
Metabolism Hepatic
Metabolites Desmethylclomipramine
Elimination half-life

CMI: 19–37 hours

DCMI: 54–77 hours

Excretion Renal (51–60%) Feces (24–32%)

The original formula was developed more than 50 years ago. Due to this fact, it is now possible for different manufacturers to use it and market their own products under different names which is why you can buy Anafranil under a different name and a cheaper price than the branded medication without compromising the effectiveness of the therapy.

When is Anafranil prescribed?

The medication is a potent antidepressant that can be used even for the most severe and long-term depressions. Usually, the positive effect of the medication is observed within three to five days of the therapy. The medication is also known to be effective in the diminishing of suicidal tendencies in people aged 65 and older.

The official indications for the drug use

Adults:
- Depressive states of different cause with different symptoms: endogenous, reactive, neurotic, organic, masked, etc.
- Depression in individuals with schizophrenia, sociopathy and dissocial personality disorder;
- Depression related to the elderly age;
- Depressive states associated with chronic pain syndrome or chronic somatic diseases;
- Phobias and panic disorders;
- Obsessive-compulsive disorder;
- Cataplexy that accompanies narcolepsy and is induced by agitation.
- Chronic pain syndrome.

Children:
- Obsessive-compulsive disorder;
- Nocturnal enuresis (bedwetting) (only for kids older than six years and in lack of organic factors).
To date, there is no sufficient data on the safety and efficiency of the medical drug use in kids with depressive states, phobias, panic disorders, cataplexy, or chronic pain syndrome. Therefore, you should buy generic Anafranil only for adolescents who reached 18 years for these conditions and not for younger kids.

When must not the use of Anafranil be considered?

Here you can find the list of conditions or circumstances in which the use of the medication is not recommended as it can do more harm than good:
- Sensitivity to the drug’s components manifested in the onset of adverse effects and especially allergic reactions;
- Sensitivity o tricyclic antidepressants of Dibenzazepine group;
- Recent myocardial infarction;
- Congenital syndrome of prolonged QT interval.
- Acute urine retention (inability to urinate);
- Acute delirium (acute hallucinations);
- Untreated glaucoma;
- Prostate hyperplasia with urine retention (inability to urinate);
- Pylorostenosis;
- Paralytic intestinal obstruction;
- Acute intoxication with other medicaments that depress the nervous system such as sleeping pills, painkillers, alcohol, and so on.
- Use in kids aged below 18 for other conditions than bedwetting and/or obsessive-compulsive disorder;
- Simultaneous use with incompatible medicaments (see the list below).
You should carefully read this list and see if you are diagnosed with any of the conditions listed. If you doubt about any of them, talk about it with your medical practitioner before you buy Clomipramine HCI.

How does the medication use affect the other medicines?

The medicament can negatively interwork with other medical substances and therefore must not be combined with:
- Antiarrhythmic meds, for instance, quinidine and propafenone, which are potent inhibitors of the CYP2D6 enzyme.
- MAO inhibitors. Their negative interaction with the medicament is so potent that it must not be used even within fourteen days after the therapy with MAO inhibitors is discontinued. The same rule must be followed if the MAO inhibitor is prescribed after previous therapy with Anafranil. In either of these cases, the initial doses of Anafranil or MAO inhibitors must be small and be raised little by little, under the constant control of the reaction of the body to the formulation.
Besides the strict prohibition of the concurrent use of certain medicines with Anafranil, it is also not advised to combine it with:
- Selective inhibitors of serotonin reuptake as it can substantially potentiate the effect on the serotonin system.
- Serotonergic agents due to the danger of serotonin syndrome development. It is encouraged to wait up to a month after the use of any serotonergic agent before using Clomipramine HCI and vice versa.
- An adrenergic antagonist that influence the neuronal transmission of agitation. The medicament can completely eliminate or diminish the blood lowering effect of the action of guanethidine, reserpine, and alpha-methyldopa, and others from the group. Thus, if when you buy generic Clomipramine HCI you also need to use blood pressure-lowering medicines you should seek for formulations with other mechanisms of action.
- Sympathomimetics’ (adrenaline, norepinephrine, ephedrine, etc.) effect on the cardiovascular system can be enhanced with negative consequences by the use of Anafranil.
- Any substances’ effect that depresses the central nervous system is enhanced by the use of tricyclic antidepressants. These substances include opiates, barbiturates, alcohol, and so on.
- Anticholinergics’ (for example phenothiazines, antiparkinsonian medications, antihistamines, atropine, and others) effect on the vision, CNS, bowel, and bladder is enhanced by the use of the medical product.
- Diuretics in combined use with Clomipramine HCI can cause hypokalemia, which, in turn, increases the risk of prolonging the QT interval and fluttering-fibrillation of the ventricles. Hypokalemia needs to be treated before the appointment of Anafranil.
These are not all interactions which mean that if you use any formulations, you must inform the medical practitioner who treats you about them before you begin the therapy with this mediation.

Possible negative effects from Anafranil use

Before you order Anafranil or any other medication, you should get acquainted with the adverse effects it can provoke:
- Constipation
- Urinary retention (inability to urinate)
- Dry mouth
- Confusion
- Low arterial pressure
- Lowered seizure threshold.

These adverse effects are basically the same as the ones caused by Imipramine use but this medication doesn’t cause the enhancement of fear and anxiety. However, as the serotonin reuptake inhibitors, Anafranil can cause sexual dysfunctions, paranoid symptoms, agitation, mania, hypomania, allergic reactions, body mass gain, and others.
Before you start the therapy your physician must inform you what adverse effects are most likely in your case and how to avoid them.

Percentage of patients reporting adverse effects in placebo-controlled clinical trials

Body System/ Adverse Reaction
Anafranil (Number of patients=322) %
Placebo Number of patients = 319) %
Somnolence
54
16
Tremor
54
2
Dizziness
54
14
Headache
52
41
Insomnia
25
15
Libido change
21
3
Nervousness
18
2
Myoclonus
13
-
Increased appetite
11
2
Paresthesia
9
3
Memory impairment
9
1
Anxiety
9
4
Twitching
7
1
Impaired concentration
5
2
Depression
5
1
Hypertonia
4
1
Sleep disorder
4
-
Psychosomatic disorder
3
-
Yawning
3
-
Confusion
3
-
Speech disorder
3
-
Abnormal dreaming
3
-
Agitation
3
-
Migraine
3
-
Depersonalization
2
-
Irritability
2
2
Emotional lability
2
-
Panic reaction
1
-
Aggressive reaction
-
-
Paresis
-
-
Increased sweating
29
3
Rash
8
1
Pruritus
6
-
Dermatitis
2
-
Acne
2
2
Dry skin
2
-
Urticaria
1
-
Abnormal skin odor
-
-
Dry mouth
84
17
Constipation
47
11
Nausea
33
14
Dyspepsia
22
10
Diarrhea
13
9
Anorexia
12
-
Abdominal pain
11
9
Vomiting
7
2
Flatulence
6
3
Tooth disorder
5
-
Gastrointestinal disorder
5
-
Dysphagia
2
-
Esophagitis
1
-
Fatigue
39
18
Weight increase
18
1
Flushing
8
-
Hot flushes
5
-
Chest pain
4
4
Fever
4
-
Allergy
3
3
Pain
3
2
Local edema
2
4
Chills
2
1
Postural hypotension
6
-
Palpitation
4
2
Tachycardia
4
-
Pharyngitis
14
9
Rhinitis
12
10
Sinusitis
6
4
Coughing
6
6
Bronchospasm
2
-
Epistaxis
2
-
Laryngitis
-
1
Micturition disorder
14
2
Urinary tract infection
6
1
Micturition frequency
5
3
Urinary retention
2
-
Dysuria
2
2
Cystitis
2
-
Dysmenorrhea
12
14
Lactation (nonpuerperal)
4
-
Menstrual disorder
4
2
Vaginitis
2
-
Local edema
2
4
Leukorrhea
2
-
Breast enlargement
2
-
Breast pain
1
-
Amenorrhea
1
-
Ejaculation failure
42
2
Impotence
20
3
Abnormal vision
4
7
Taste perversion
8
-
Tinnitus
6
1
Abnormal lacrimation
3
2
Mydriasis
2
1
Myalgia
9
-
Back pain
6
6
Back pain
3
5
Muscle weakness
1
-
Purpura
3
-
Thirst
2
2

How to take Anafranil?

Before you order generic Anafranil you should know that it’s the best that the doses are selected individually for any case. The optimal therapy is made with the optimal dosage identification which would be the lowest effective dosage. The therapy is started with the low doses with careful dosage increase especially in patients aged 65 and more years.
After carrying out maintenance therapy, the optimal dose should be followed. Patients with recurrence of depression in the history of maintenance therapy can be indicated for a long period of time, depending on the individual risk of recurrence. The duration and need for further therapy must be reviewed throughout the therapy course.
To prevent possible prolongation of the QT interval and the appearance of serotonergic toxicity, do not exceed the appointed dosages of Anafranil. In the simultaneous application of other serotonergic drugs or medicines that prolong the QT interval with Anafranil, any elevation of the dose requires caution.
It is not encouraged to sharply cancel the therapy. The dosages must be gradually lowered and the condition of a patient observed by a medical specialist.
- Depression, obsessive-compulsive disorder, and phobia are managed with one 25 mg pill two-three times a day. Within the first week the dosage is gradually raised, for instance, by 25 mg every few days till the achievement of the daily dose of 4-6 25 mg pills. The maximum dose a day suitable for severe cases and only if the medication is well tolerated is 250 mg. After the improvement is achieved, a lower maintenance dosage which is usually 2-4 25 mg pills a day is chosen.
- Panic disorders, agoraphobia. The treatment begins with the application of 10 mg per day. Then, depending on the tolerability of the medication, its dosage is increased to achieve the desired effect. The effective dosage is usually found somewhere in the range between 25 and 100 mg. If necessary, it can be raised to 150 mg a day. After the pronounced effect is achieved, the maintenance dosage is reduced to the lowest that provides sufficient effect.
- Cataplexy is treated with 25-75 mg a day.
- Chronic pain syndrome is treated with the individually chosen doses depending on the intake of analgesics (painkillers).

Children

- Obsessive compulsive disorder is treated with 25 mg a day with the gradual increase of the dosage by 3 mg per kg of the body weight or 100 mg within the first two weeks.
- Bedwetting is treated with 20-30 mg for kids aged 6-8 years- 20-30 mg a day; 9- 12 years – 1-2 25 mg pills; 12 years and more – 1-3 25 mg pills.

Where can you buy Anafranil?

If you have Rx, you can get the medication from literally any drugstore. But if you want to spare some money, you can order Clomipramine HCI from out drugstore and get the same effect at the low price.

Clomipramine HCI shipping

You can order the pills from any country of the world. We will ship it to your doorstep!

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
Product Reviews:
   

 
Sep / 02 / 2017 Kirsten Moore   USA, Boaz
  item as described. thank you
   
 
 
Aug / 17 / 2017 Heidi King   USA, Newman
  Fast, easy sale.
   
 
 
Jan / 02 / 2017 Aiden Young   USA, Florida
  Exactly the same as my prescription tablets but at a fraction of the price.
   
 


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