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4RX Store > Medication List > Anti Depressants drugs > Order Cymbalta online

Anti Depressants Medication (Cymbalta)

Generic name:
Brand name:
Cymbalta or the active substance Duloxetine is a potent antidepressant from the group of the selective serotonin and norepinephrine reuptake inhibitors. It is appointed for major depression, anxiety, and diabetic peripheral neuropathic pain as its mechanisms have calming and painkiller effects. How the medication is used for each of these conditions and when it must not be used as well as other useful information can be found in our detailed guide.
Major depressive disorder, Diabetic peripheral neuropathic pain, Generalized anxiety disorder.
Helps to relieve depression symptoms, anxiety, and reduce pain syndrome
Sun Pharmaceutical Industries Ltd.
Sun Pharmaceutical Industries Ltd.
Cymbalta (Generic Duloxetine)
Actual product may differ in
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Order Generic Duloxetine Buy Cymbalta 20mg


Quantity (max. 2)   Package   Price, USD   You save








  60 pills
$65.00 ($68.45)








  90 pills
$100.00 ($109.52)








  120 pills
$130.00 ($141.63)








  240 pills
$260.00 ($278.52)








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  Generic Medication guide:

What is the medical product called Cymbalta? When is it appointed?

The trademark Cymbalta is registered for a medicinal product Duloxetine that is an internationally used antidepressant. The same medication can be made and sold under different trademarks. This particular name is owned by the American pharmaceutical company Eli Lilly & Company and cannot be used by other companies yet you can technically buy Cymbalta but under a different name at our online drugstore made by Sun Pharma, one of the largest and world-acknowledged Indian generics makers.
The active ingredient of the medical product is a serotonin and norepinephrine reuptake inhibitor that also slightly suppresses dopamine uptake. It has an antidepressive, mild calming, and painkiller properties.

Short drug info
Trade names Cymbalta, many others
Pregnancy category

AU: B3

US: C (Risk not determined)

Routes of administration Oral
Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only

Bioavailability ~ 50% (32% to 80%)
Protein binding ~ 95%
Metabolism Liver
Metabolites Desmethylcitalopram (DCT) and didesmethylcitalopram (DDCT)
Elimination half-life 12.1 hours
Routes of excretion 70% in urine, 20% in feces

The formulation is approved and appointed if the following conditions are diagnosed:

- Major depressive disorder;
- Neuropathic pain associated with diabetes;
- Generalized anxiety.
The active agent is well digested when taken orally and it doesn’t matter whether the pills are taken with or without food – the efficiency is still the same.

When it is not advised to take Cymbalta?

Some people, even if they are diagnosed with the conditions treated with this drug, may be unable to use the antidepressant because it use will do more harm than good to them due to certain circumstances. For instance, you must not buy generic Cymbalta and use it if you have:
- Increased sensibility to the drug
- Unstable hypertension
- Terminal renal dysfunction (cc less than 30 ml per minute)
- Liver diseases
Besides, the drug is prohibited to be given to children including through breast milk, i.e. a breastfeeding mother should disrupt breastfeeding for the therapy with the drug.

It also must not be taken by adults in combination with:
- MAO inhibitors (and a half of a month after their use discontinuation)
- Fluvoxamine, ciprofloxacin, or enoxacin (strong inhibitors of CYP1A2) due to elevated Duloxetine level in the blood plasma.

The limitations for use (undesirable use) are:
- Mania and bipolar disorder
- Seizures
- High intraocular pressure and/or the risk of acute close dangle glaucoma development
- Suicidal tendencies (including history)
- The risk of hyponatremia (dehydration, use of diuretics, liver cirrhosis)
- Elderly patients
- Pregnancy.

Adverse effects Cymbalta tablets can cause

When you buy Duloxetine you should understand that there are basically no medications that are absolutely free of side effects. It doesn’t mean that any drug necessarily causes adverse effects if you use it but still, such likelihood exists. The possible Cymbalta adverse effects are:

From the part of the nervous system (sorted by descending incidence):
- Headache
- Dizziness
- Sleepiness
- Tremor
- Insomnia
- Unusual dreams
- Anxiety
- Agitation.
The rarest adverse effects from the side of the nervous system are mania, aggression, suicidal tendencies, and so on.

From the part of the digestive system (sorted by descending incidence):
- Nausea
- Dryness of the mouth
- Diarrhea
- Constipation
- Vomiting
- Dyspepsia (poor digestion, heaviness in the stomach)
- Taste perception impairment
- Liver failure and others.

From the part of the urinary and reproductive system (sorted by descending incidence):
- Erectile dysfunction
- Low libido
- Urinary retention (inability to urinate)
- Impaired ejaculation
- Alteration of the urine smell
- Symptoms of menopause, and others.

From the part of the cardiovascular system (sorted by descending incidence):
- Rapid heart rate
- Flushes
- Tachycardia (irregular heart rate)
- Low arterial pressure and passing out
- High arterial pressure
- Heart function violation, and others.

From the part of the sensory organs (sorted by descending incidence):
- Blurred vision
- Noise in the ears
- Vertigo (dizziness)
- Glaucoma, and so on.

From the part of the respiratory tract (sorted by descending incidence):
- Yawning
- Nasal bleeding
- The sensation of compression of the pharynx.

From the part of the skin (sorted by descending incidence):
- Skin rash
- Increased sweating
- Sensitivity to light
- Increased bruising
- Swelling
- Stevens-Johnson syndrome, and others.

From the part of the musculoskeletal system (sorted by descending incidence):
- Muscle spasm,
- Muscle or bone pain,
- Muscular stiffness;
- Muscle twitching, and others.

From the part of metabolism (sorted by descending incidence):
- Decreased appetite
- Hyperglycemia (mainly in people with diabetes)
- Dehydration, and others.
Other adverse effects include lowering of the body mass or gain of the body mass, fatigue, gait disturbance, sensitivity disturbance, sensation of cold, sensation of heat, thirst, chills, and others.
In sharp discontinuation of the therapy, the most frequent side effects are dizziness, sensory violations, sleep disturbance, agitation, anxiety, nausea, vomiting, tremor, headache, irritability, diarrhea, and others.

Adverse effects incidence of 5% and greater than placebo in placebo-controlled trials (percentage of patients)

Body System/Adverse Reaction
CYMBALTA (Number of patients = 8100) %
Placebo Number of patients = 5655)%
Dry mouth
Decreased appetite
Abdominal pain

To know what side effects are dangerous and indicate that you must stop using the drug, consult your physician before you buy generic Duloxetine from our med store.

How must Duloxetine pills be taken?

- Depression and diabetic peripheral neuropathic pain treatment are started with 60 mg taken once daily regardless of mealtime. If the effect is insufficient, the dosage can be raised to 120 mg split into two intakes. The intake of 120 mg a day is the maximum safe one.
- Generalized anxiety is treated with 30 mg taken once daily regardless of mealtime. If the effect is insufficient, the dosage can be raised to 60 mg a day. If it is still not enough, it is admissible to raise it to 90 or 120 mg but then the dosage must be split into two intakes.

Overdose of Cymbalta

The signs of an overdose are vomiting and lack of appetite, tremor, seizures, and so on.
It requires symptomatic treatment, control over the function of the cardiovascular system and vital functions.

Special recommendations for Cymbalta use

Before you order Cymbalta, you must discuss the reasonability and safety of the therapy with the drug in your case with your healthcare provider.
In depression, suicidal tendencies and attempts can occur and remain till the onset of persistent remission. Thus, the individuals in the risk group must be observed by a healthcare specialist.
The cancellation of the formulation use must be done by gradual diminishing of the dosage to avoid withdrawal syndrome.
Since there is no sufficient practice of use of the medicament during pregnancy it is advised to use Duloxetine in expecting women only if the attending qualified doctor believes that the benefit exceeds the risks for the fetus. Women who take the pills must be notified that if they plan pregnancy or accidentally get pregnant while using the pills they must inform their doctors.
During the tests of Duloxetine, no impairment of psychomotor reactions, cognitive functions, and memory had been observed. However, the use of the drug can be accompanied by sleepiness. Thus, when you order generic Cymbalta, you should refrain from driving or engaging in any potentially dangerous activities that require focus at least during the first week.

Mechanism of Cymbalta effect

The medicinal product inhibits the serotonin and norepinephrine reuptake, resulting in increased serotonergic and noradrenergic neurotransmission in the central nervous system. It also mildly suppresses the reuptake of dopamine and doesn’t significantly interact with histaminergic, dopaminergic, cholinergic and adrenergic receptors.
The medication has a central mechanism of suppression of the pain syndrome that is mainly manifested in the raise of the pain threshold in neuropathic pain syndrome.

Where can you buy Duloxetine?

The formulation is sold at the regular and online drugstores with or without Rx depending on the country. If you live in the country where it is sold with Rx, you can order Duloxetine from our med store and save both on the visits to your doctor for a prescription and the pills themselves because we offer you a qualitative generic and not the branded drug.

Cymbalta (Duloxetine) shipping

We offer worldwide shipping including free shipping on orders with the total cost of 170 USD or more.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section


Product Reviews:

Jul / 18 / 2017 jim Pittner   USA, Quincy
  this is a reliable pharmacy
Feb / 28 / 2017 kelly cooper   Australia, Greensborough
  Order arrived timely as was promised.
Dec / 19 / 2016 Timothy Shear   USA, Temecula
  Except a bit slow shipment, everything is fine such as good communication and etc

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