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4RX Store > Medication List > Anti Depressants drugs > Order Effexor online

Anti Depressants Medication (Effexor)

 
Generic name:
Effexor
Brand name:
Venlafaxine
Description:
The drug you can purchase at this webpage is Generic Effexor, i.e. the same Effexor but made by Cipla and not Wyeth. The medication is based on Venlafaxine, an antidepressant that inhibits the reuptake of serotonin and norepinephrine and is effective against major depressive disorder, prophylaxis of depression, anxiety disorder, phobias, and so on. The information about dosages, precautions, interactions, etc. can be found in the guide below.
Indications:
Major depressive disorder, Depression, Prophylaxis of depression, Generalized anxiety, Phobia
Benefits:
Helps to cure depression and prevent its flare ups
Manufacture:
Cipla - Caring for life
Cipla - Caring for life
Synonyms:
Venlor, Ventab, Elafax, Venlafaxina
 
   
Effexor (Generic Venlafaxine)
 
Actual product may differ in
appearance from image shown.
 
 
 
 

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  Generic Medication guide:

What is the medical product sold under the trademark Effexor? When can it be utilized?

Effexor is the trademark owned by a large pharmaceutical company Wyeth. The substance on which this formulation is based was developed back in 1993. Since then, the exclusive patent of its developer had already expired what made it possible for different pharmaceutical enterprises make the same formulations but sell them using other commercial names. If you have to buy Effexor, you can as well opt for generic Effexor which is the identical formulation just made and sold by another company.
Venlafaxine, the active agent of the brand formulation and its cheaper analogs is an antidepressant from the selective serotonin-norepinephrine reuptake inhibitors group. The standard form of the product is appointed for the therapy of depression and its prophylaxis. Besides, various other forms, for instance, extended-release tablets, are utilized for anxiety, various phobias, neuroses and other conditions.

The mediation is acknowledged as one of the most effective and harmless antidepressants used today according to the comparative study published in the scientific magazine The Lancet in 2009.

Short drug info
Trade names Effexor, many generics
Pregnancy category AU: B2 US: C (Risk not identified)
Routes of administration By mouth
Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only

Bioavailability 42±15%
Protein binding 27±2% (parent compound), 30±12% (active metabolite, desvenlafaxine)
Metabolism Hepatic (liver)
Elimination half-life 5±2 h (parent compound for immediate release formulations), 15±6 h (parent compound for extended release formulations), 11±2 h (active metabolite)
Excretion Renal (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites)

When must not the formulation be used?

You must not buy Generic Effexor or the branded drug even if it is indicated for you if you have:
- Increased sensitivity to Venlafaxine or additional components of the pills;
- Use any MAO inhibitors including reversible, irreversible, selective and non-selective.
- High risk of severe ventricular arrhythmia. For instance, in the case of significant dysfunction of the left ventricle of the heart of the III-IV functional class by the criteria of the New York Heart Association
- Severe stage of arterial hypertension (blood pressure 180/115 mm Hg or higher before the beginning of the therapy).
- Glaucoma;
- Severe liver or kidney insufficiency;
- Troubled urination due to the impaired urine outflow, for instance, in benign prostatic hyperplasia (prostatitis).
The formulation can be used during pregnancy at a doctor’s discretion only if the benefit is anticipated to be higher than the risk.
Besides the listed conditions, the pills are not advised to be utilized in elevated intraocular pressure, manic conditions (including history), body weight below the norm, and in individuals aged less than eighteen years.

What unpleasant symptoms can the use of Effexor cause?

The most frequent adverse effects related to the use of the formulation that occurred in five or more percents of patents are:
- Sweating
- Feeling sick
- Vomiting
- Constipation
- Loss of appetite
- Sleepiness
- Dryness of the mouth
- Lightheadedness
- Irritability
- Tremor
- Vision acuity impairment
- Erectile and ejaculation dysfunction
- General weakness
- Headache, and others.
If an individual who plans to use the medication suffers from any chronic conditions, the likelihood of adverse effects occurrence from the part of the affected body system is increased. Thus if you do have any conditions especially the ones related to the heart, you need to get a comprehensive assessment of your condition by a specialist before you buy Venlafaxine and start using it.

Effexor adverse effects occurrence in 4 to 8 week placebo-controlled clinical trials

Body System/ Adverse Reaction
Effexor (Number of patients = 1033) %
Placebo (Number of patients =609) %
Headache
25
24
Asthenia
12
6
Infection
6
5
Chills
3
0
Chest pain
2
1
Trauma
2
1
Vasodilatation
4
3
Increased blood pressure/hypertension
2
0
Tachycardia
2
0
Postural hypotension
1
0
Sweating
12
3
Rash
3
2
Pruritus
1
0
Nausea
37
11
Constipation
15
7
Anorexia
11
2
Diarrhea
8
7
Vomiting
6
2
Dyspepsia
5
4
Flatulence
3
2
Weight loss
1
0
Somnolence
23
9
Dry mouth
22
11
Dizziness
19
7
Insomnia
18
10
Nervousness
13
6
Anxiety
6
3
Tremor
5
1
Abnormal dreams
4
3
Hypertonia
3
2
Paresthesia
3
2
Libido decreased
2
0
Agitation
2
0
Confusion
2
1
Thinking abnormal
2
1
Depersonalization
1
0
Depression
1
0
Urinary retention
1
0
Twitching
1
0
Yawn
3
0
Blurred vision
6
2
Taste perversion
2
0
Tinnitus
2
0
Mydriasis
2
0
Abnormal ejaculation/orgasm
12
0
Impotence
16
0
Urinary frequency
3
2
Urination impaired
2
0
Orgasm disturbance
2
0

Is it safe to use Venlafaxine along with other medications?

While with some medication the drug absolutely not interacts and therefore can be without any doubts combined, it must not be used with MAO inhibitors as the risk of severe adverse reactions sharply increases in such a combination.
In the use of the formulation, serotonin syndrome can develop. The risk is elevated if it is combined with medications that influence serotonergic neurotransmission including triptans,  serotonin reuptake inhibitors, selective serotonin-noradrenaline reuptake inhibitors, lithium, Sibutramine, Tramadol, Hypericum perforatum, formulations that disrupt serotonin metabolism, or serotonin precursors. The manifestations of serotonin syndrome include the change of the mental status, neuromuscular disorders, negative systems from the gastrointestinal tract, and so on.
The risk of negative effects development in the use of the formulation along with other substances that influence the central nervous system hadn’t been sufficiently studied. Thus, it is advised to render caution taking the formulation with any other substances that influence the CNS.
The lowering of the cognitive functions wasn’t observed in the use of alcohol along with this antidepressant yet since it influences the CNS, it is still advised to refrain from alcohol intake during the therapy.
This list includes only the most notable interactions but the medication also interacts with other drugs and substances. Thus, before you buy Generic Venlafaxine and begin to use it, make sure to consult a specialist mentioning all the substances that you take.

How is Venlafaxine administered?

To minimize the risk of adverse effects occurrence likelihood, the tablets should be taken during meals at the same hour every day.
It is recommended to initiate therapy with 75 mg taken once a day. In the inadequate effect, the dosage can be gradually raised to 75 mg taken twice a day. The max safe dosage is 225 mg a day divided into several intakes. The dosage raise is made not sooner than in two weeks after the use of the previous dosage and only if the drug doesn’t cause any adverse effects.
If an individual is treated at the hospital and acute episode requires higher dosages, at a doctor’s discretion and under their supervision the daily dosage of the drug can be elevated to 375 mg divided into several intakes. Once the expected result is achieved, the daily dosage is gradually lowered to the standard dosages.
In general, it is preferable to use the minimum effective dosages, i.e. the lowest dosage that successfully diminishes the manifestations of depression.
Treatment of depression requires substantial period of time, usually, from several months to several years. The effectiveness of the therapy with this medication must be regularly reviewed.
The long-term use of the formulation can be also suitable for the prophylaxis of depression relapses. In the most cases, the prophylaxis dosage is equal to the dosage used for the treatment.
Once remission is achieved, the treatment with antidepressive medications must be continued for at least six months.

Dosage adjustments for different groups of patients

- People older than 65.
The age of the patient itself doesn’t require the dosage adjustment, Therefore, if people over 65 years do not have any kidney or liver dysfunction, they should take the same dosages but it is still preferable for them to use the lowest possible dosage and if an elevation of the dosage is needed, it should be made under a doctor’s supervision.
- People with liver failure.
Individuals with mild to moderate liver failure are recommended using a half of the standard dosage. There are limited data on the safety of the formulation use in severe liver failure so they should take it cautiously and only if the doctor approves. In their case, the dosage must be lowered on more than a half.
- People with kidney failure.
Patients with cc between 30 and 70 ml per minute do not require the dosage lowering. However, they are still advised to take the medication cautiously. People with severe kidney failure with cc lower than 30 ml per minute or on hemodialysis are advised to lower the dosage by a half. However, the precise dosage must be chosen by a doctor even if you order Effexor online without Rx.

Principle of action

The antidepressive effect of the formulation is due to the enhanced neurotransmitter activity in the CNS. The trials had shown that it is a potent inhibitor of the reverse neuronal capture of serotonin and norepinephrine and a mild inhibitor of dopamine re-capture. The effect is achieved both by the active agent and its metabolite, i.e. the substance it partially transforms into in the body.
After the oral intake, the formulation is well digested and is metabolized in the liver. After the intake of a single dosage, around 92% is absorbed. The total bioavailability to the drug is 45% due to its pre-systemic metabolism.  Food doesn’t influence the absorption and transformation of the medication in the body.
The half-life of Venlafaxine is about five hours, and of its metabolite - 11 hours. It means that they are fully washed out of the body within this time.

Overdose danger and treatment

An overdose of Effexor or its analogs is fraught with the onset of severe adverse effects and irreversible harm to your health. Even if you take the standard dosage but take the incompatible substances along with this antidepressant you can develop signs of an overdose. These substances include alcohol, CNS depressants, other antidepressants, MAO inhibitors, etc.
The typical signs of an overdose are confusion, sluggishness, nausea, diarrhea, tremor, sharp arterial pressure changes, seizures, and others.
The first measure to undertake is vomiting and the intake of sorbent. At the same time you should call the ambulance or go to the hospital as an overdose with antidepressants requires medical assistance.

Where can you purchase Effexor?

In the most states, such medicines as Effexor are sold with Rx from the therapist only but there are exceptions. For instance, our drugstore is located in the country where it can be purchased without Rx. Besides, we offer a free doctor consultation so that when you order Generic Effexor you’d be certain that you get the right formulation for your condition.

Generic Effexor shipping

4RXstore ships all that we offer worldwide. You can choose between faster but more expensive delivery and standard shipping with the minimal cost that takes up to a month.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
Product Reviews:
   

 
May / 10 / 2018 amy case   USA, Denver
  Speedy service and good price too
   
 
 
Dec / 27 / 2017 justin schoemann   USA, Quincy
  All Good. Thanks!
   
 


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