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4RX Store > Medication List > Anti Depressants drugs > Order Paxil online

Anti Depressants Medication (Paxil)

 
Generic name:
Paxil
Brand name:
Paroxetine
Description:
Paxil is a commercial name owned by a certain pharmaceutical company for the active substance Paroxetine that is a powerful serotonin reuptake inhibiting antidepressant used for depression, panic disorder, social phobias, post-traumatic stress disorder, and other conditions at your doctor’s discretion. The medication is prohibited for children and pregnant women and can be used by adults older than 18. For more detailed information read the full guide.
Indications:
Depressive disorders, Social phobias, Social anxiety disorders, Panic disorder, Nightmares, Obsessive-compulsive disorder, Generalized anxiety, Post-traumatic stress disorder
Benefits:
The medication successfully eliminates the symptoms of depression, anxiety, post-traumatic disorder, and other mental disorders listed in the instruction
Manufacture:
IPCA - A dose of life
IPCA - A dose of life
Synonyms:
Pexap, Pexep, Teprox, Aropax, Pexeva, Seroxat
 
   
Paxil (Generic Paroxetine)
 
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  Generic Medication guide:

What is Paxil? When can it be used?

The brand Paxil is a trademark of GlaxoSmithKline, a British pharmaceutical company. It is registered for Paroxetine, a potent antidepressant with significant anti-anxiety effect from the class of selective serotonin reuptake inhibitors. The active substance was developed and first patented in 1973 by a pharmaceutical company A/S Ferrosan. Currently, by virtue of the expiry of the patent protection period, it has moved to the category of generics, i.e. you can buy Paxil under another name and at another price if it is made by a different pharmaceutical company than the owner of the brand.

The indications for the utilization of the formulation are:
- Depressive disorders. The formulation is used for the therapy of depression of any type including reactive, severe depression, and depression with pronounced anxiety. In case the therapy is successful, the pills can be also used as a prophylaxis of relapses.
- Social phobias. The formulation is utilized for social anxiety disorders and prophylaxis of relapses.
- Panic disorder. The formulation is used for the management of symptoms and prevention of recurrence of panic disorder with concomitant agoraphobia or without it.
- Nightmares;
- Obsessive actions and thoughts elimination and prophylaxis in obsessive-compulsive disorder.
- Generalized anxiety;
- Post-traumatic stress disorder.

Please note that it is not the only medicinal product that can be used in these disorders. Thus, your therapist may prescribe you another formulation if he or she considers it a better choice for your case. Besides, if you have any adverse effects from the use of the substance use when you buy generic Paxil, do not despair – you have a wide variety of antidepressants to choose from at our online drugstore at low prices.

Clinical data
Trade names
Paxil, Pexeva, Seroxat, others
Pregnancy category
AU: D
US: D (Evidence of risk)
Routes of administration
Oral
Legal status
AU: S4 (Prescription only)
CA: RX-only
UK: POM (Prescription only)
US: RX-only
Bioavailability
Extensively absorbed from the GI tract, but extensive first-pass metabolism in the liver
Protein binding
93-95%
Metabolism
Liver
Elimination half-life
21 hours
Excretion
Renal (64%; 2% unchanged and 62% as metabolites), Fecal (36%; <1% unchanged)

When does Paxil must not be used?

The prohibitions include:
- Allergy to Paroxetine;
- Therapy with MAO inhibitors (and fourteen days after their use discontinuation);
- Age below 18 years.

The administration of the pills should be also limited in:
- Closed-angle glaucoma;
- Benign prostatic hyperplasia;
- Mania;
- Heart pathology;
- Epilepsy (in unstable epilepsy, the use of the formulation should be avoided);
- Convulsive conditions;
- The appointment of electropulse therapy;
- The use of medicines that increase the risk of bleeding;
- Diseases that increase the probability of bleedings;
- Elderly age;
- Liver or kidney failure.

Use of Paxil during pregnancy and breastfeeding

The use of the formulation is prohibited during pregnancy as it can cause certain birth defects. During the trials it had been noted that the use of the antidepressant during the first trimester of pregnancy may be associated with an increased incidence of cardiovascular disorders in babies, for instance, atrial or ventricular septal defect.
During the therapy with Paroxetine it is also advised to stop breastfeeding and transfer your baby to formula feeding as the medicinal product can penetrate the breast milk.

Paxil dosage and treatment regimen

When you buy Paroxetine, the best way to select the right dosage and guard yourself from unexpected events is to follow your therapist’s order without any changes. Here we provide the dosages and treatment regimens descriptions available in the instruction that comes with the pills for information only.
The tablets must be swallowed entirely with sufficient amount of water preferably with a meal in the first half of a day.
As with other antidepressants, the most effective and suitable dosages are identified with the thorough adjustment of the regular dosages within the first two to three weeks of the therapy.
The therapy course must be sufficiently long to ensure complete symptoms elimination and prevent relapses. This period can last from several months to years especially for obsessive-compulsive disorder and panic disorder. Also, as with the case with other medicines for mental health, it is advised to avoid abrupt cessation of the therapy.
- Depression is treated with 20 mg a day. For the treatment of some patients higher dosages can be required. The dosage can be raised by 10 mg every 2-3 weeks up to 50 mg if the medicine is well tolerated.
- Obsessive-compulsive disorder is treated with 20 mg a day with the subsequent elevation to 40 mg a day by 10 mg every week. In some patients, the improvement is observed only in the reaching of the dosage of 60 mg a day.
- Panic disorder. The dose is 40 mg taken daily. The course must be started with 10 mg a day with the subsequent elevation by 10 mg once a week. It is advised to start from the lowest dosage to avoid the worsening of panic disorder symptoms at the beginning of the therapy. In some patients, the improvement is observed only in the reaching of the dose of 50 mg daily.
- The daily dosage for social anxiety disorders is 20 mg a day. The dosage can be raised by 10 mg once a week until the desired effect is achieved but not above 50 mg a day.
- The daily dosage for generalized anxiety is 20 mg a day. The dosage can be raised by 10 mg once a week until the desired effect is achieved but not above 50 mg a day.
- The daily dosage of Paxil for post-traumatic stress disorder is 20 mg a day. The dosage can be raised by 10 mg once a week until the desired effect is achieved but not above 50 mg a day.

Dosage adjustments for special groups of patients

- People over 65 years of age can start the course with the same dosages of Paxil but should not increase the daily dosage above 40 mg.
- In kidney and liver failure, individuals are treated with the lowest dosages of the formulation as the conditions of moderate to severe stage significantly influence the level of Paxil in the blood.

Paxil withdrawal

When you buy generic Paroxetine you must know that when you achieve the desired effect you must not abruptly stop the therapy or you will suffer from withdrawal or relapse of the treated condition. Instead, it is recommended to lower the dosage of the formulation gradually by 10 mg a week till the complete discontinuation. In case adverse effects of withdrawal still develop, it is reasonable to resume using the formulation in the previous dosage with subsequent lowering of the dosage at a slower pace, for instance,  5 mg a day once a week.

Paroxetine adverse effects

The possible negative events that you can suffer from while using this medication are:
- Dizziness, headache, sleepiness or sleeplessness, unhealthy excitability,  anxiety, irritability, emotional instability, neurosis, inability to focus, slowing down of thinking, aggressiveness, tremor, seizures, extrapyramidal symptoms, hallucinations, euphoria, mania or hypomania, confusion, memory impairment, panic attacks, paresthesia, serotonin syndrome, visual impairment, and taste change, and others.
- Muscle spasms, myalgia, myasthenia gravis, and others.
- Erectile dysfunction, ejaculation disorder, low libido, urine retention or frequent urination.
- Loss or increase of appetite, dry mouth, nausea, stool disorder.
- Increase or lowering of blood pressure, rapid heartbeat.
- Allergic reactions: skin rash, itching, edema.
These are only some of the adverse events that can occur.  You won’t necessarily develop any of them or even if you do, they can fade once your body gets used to them but if they only worsen –inform your therapist or another medical professional who knows your health history.

Adverse effect Incidence in Placebo-Controlled Clinical Trials for Major Depressive Disorder (percentage of patients)

Adverse effect
PAXIL
(n = 421)
Placebo
(n = 421)
Headache
18%
17%
Asthenia
15%
6%
Palpitation
3%
1%
Vasodilation
3%
1%
Sweating
11%
2%
Rash
2%
1%
Nausea
26%
9%
Dry Mouth
18%
12%
Constipation
14%
9%
Diarrhea
12%
8%
Decreased Appetite
6%
2%
Flatulence
4%
2%
Oropharynx Disorder
2%
0%
Dyspepsia
2%
1%
Myopathy
2%
1%
Myalgia
2%
1%
Myasthenia
1%
0%
Somnolence
23%
9%
Dizziness
13%
6%
Insomnia
13%
6%
Tremor
8%
2%
Nervousness
5%
3%
Anxiety
5%
3%
Paresthesia
4%
2%
Libido Decreased
3%
0%
Drugged Feeling
2%
1%
Confusion
1%
0%
Yawn
4%
0%
Blurred Vision
4%
1%
Taste Perversion
2%
0%
Ejaculatory Disturbance
13%
0%
Other Male Genital Disorders
10%
0%
Urinary Frequency
3%
1%
Urination Disorder
3%
0%
Female Genital Disorders
2%
0%
Overdose of Paroxetine

Besides the adverse effects listed in the corresponding section, in an overdose of the medication, you can also have a fever, involuntary muscle contractions, anxiety, and tachycardia.
Usually, these manifestations go away without any consequences even in a single time use of 2000 mg. The danger of serious consequences such as coma or death is possible in the combination of the formulation with other medications or alcohol in large amounts.
The treatment includes general therapeutic measures similar to those in an overdose of other substances: vomiting induction, intake of activated carbon, gastric lavage, and control over the heart and other vital organs and systems function.

Interactions of Paxil

- The medication is contraindicated to be taken at the same time with MAO inhibitors and even 14 days after the last day of MAO inhibitor use.
- The formulation must be carefully combined with any medications that influence the serotonin levels such as SSRI, Lithium, and others.
- Ritonavir significantly lowers the plasma level of Paroxetine which is why the dosage increase of the latter may be needed.
- The combination with the formulations that render anticoagulant effect can cause the enhancement of the latter’s effect and the risk of bleeding.

Please keep in mind that these are not all negative interactions with Paxil. If you use any medicinal products, even vitamins or supplements, inform your medical care provider and consult him or her whether the combination of your medicines with this antidepressant is allowed.

Precautions to follow with Paxil use

Besides not using the medicine in the conditions it can be harmful for and not combining it with other medicines which negative effects it can enhance you should also follow the following precautions when you order Paxil:
- At the beginning of the therapy, the enhancement of the panic disorder symptoms can be observed and therefore the simultaneous use of anxiolytics (anti-anxiety medicines) is recommended for the first two weeks of treatment.
- People with suicidal tendencies must be thoroughly monitored especially at the beginning of the therapy.
- In pronounced sedative effect, it is recommended to take the tablets at the evening.
- During the use of generic Paxil it is prohibited to drink alcohol.
- The product is cautiously prescribed to drivers and people whose work requires increased vigilance as Paroxetine can slow down the reactions.
- The use of Paxil as the use of other antidepressants can cause pupils dilation which in sensitive patients with the predisposition can cause episode of closed-angle glaucoma.

Where can you purchase Paxil?

If you have Rx you can get the medication virtually at any drugstore but if you which to get the pills cheaper you should order generic Paxil from our online med store.

Paxil shipping

We deliver all products that we offer internationally: to Europe, Asia, USA, Australia, etc. You can enjoy free delivery if you order pills for 170 USD or more.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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