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4RX Store > Medication List > Anti Depressants drugs > Order Sinequan online

Anti Depressants Medication (Sinequan)

 
Generic name:
Sinequan
Brand name:
Doxepin
Description:
The medication you can buy at this webpage can be found under the brand name Sinequan and many others because the formula of its main agent, Doxepin, can be used by different companies. The medication is a tricyclic antidepressant that can be used for neuroses and depression of different nature, anxiety, premenstrual syndrome, therapy of gastric and duodenum ulcer, and other conditions as the discretion of your therapist. The formulation is safe for adults and senior patients (in lower doses) but not for pregnant women as it can harm the fetus. Read our guide to find out more detailed information about this medical product.
Indications:
Neurotic disorders, Depressive and anxiety disorders of various nature and cause, Therapy of stomach and duodenum ulcer, Premenstrual syndrome, Chronic pains in cancer patients, Skin itching, Chronic idiopathic urticaria, Dumping syndrome
Benefits:
The formulation helps to minimize and subsequently completely eliminate the symptoms of depression, neurosis, and other conditions it is appointed for
Manufacture:
Ranbaxy Pharmaceuticals
Ranbaxy Pharmaceuticals
Synonyms:
Doxin, Doxipin, Spectra, Adapin, Aponal, Curatin, Quitaxon, Triadapin, Zonalon
 
   
Sinequan (Generic Doxepin)
 
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appearance from image shown.
 
 
 
 

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  Generic Medication guide:

What is Sinequan? When is this medicine appointed?

Sinequan is a Pfizer’s brand for the medicinal agent Doxepin that is a tricyclic antidepressant. The same formulation is produced and marketed by different manufacturers since the patent for the exclusive production of Pfizer had already expired. However, to find those medicines that are cheaper you need to look for generic Sinequan when your doctor’s orders tell you to buy Sinequan.

This antidepressant has anxiolytic (anti-anxiety) and sedative properties, antihistamine, as well as antiulcer action and thus is appointed for:
- Neurotic disorders with the symptoms of depression or anxiety;
- Organic neuroses associated with insomnia;
- Depressive and anxiety disorders associated with alcoholism;
- Depression and anxiety associated with somatic disorders and diseases.
- Depression and anxiety associated with somatic disorders (physical illness) and diseases.
- Depression accompanied by fear and anxiety on the background of psychosis, including Involutional depression and depressive phase of bipolar disorders.

Besides, some doctors can prescribe this medical product also for:
- Therapy of stomach and duodenum ulcer;
- Premenstrual syndrome;
- Chronic pains in cancer patients;
- Skin itching;
- Chronic idiopathic urticaria;
- Dumping syndrome (accelerated movement of stomach contents into the intestines without proper digestion).

Although our international med store offers you to buy generic Sinequan made by Ranbaxy without Rx, we advise you to consult the doctor that knows your illness history and can give you a qualified and personalized advice about the therapy.

Clinical data
Trade names
Sinequan, many others
Pregnancy category
AU: C
US: B (No risk in non-human studies)
Routes of administration
By mouth, topical, intravenous, intramuscular injection
Legal status
AU: S4 (Prescription only)
CA: RX-only
UK: POM (Prescription only)
US: RX-only
Pharmacokinetic data
Bioavailability
13-45% (mean 29%)
Protein binding
76%
Metabolism
Hepatic (CYP2D6, CYP2C19)
Metabolites
Nordoxepin, glucuronide conjugates
Elimination half-life
Doxepin: 8-24 hours (mean 17 hours)
Nordoxepin: 31 hours
Excretion
Urine: ~50%
Feces: minor

When must not generic Sinequan be used?

The medication use can be harmful in the presence of certain conditions and therefore must not be used in:
- Allergy to its components or other tricyclic antidepressants;
- Manic episodes;
- Severe liver dysfunction;
- During pregnancy and breastfeeding;
- Glaucoma;
- Predisposition to urine retention;
- Simultaneous use with MAO inhibitors and 14 days after their discontinuation.
- AV block;
- Benign prostatic hyperplasia.

If you have any chronic or acute conditions but are unsure whether they can be included in one of the listed disorders, discuss the symptoms with your healthcare provider before you buy Doxepin.

What adverse effects can Doxepin induce?

All medicinal products can be a reason for adverse effects development including this one. The possible negative effects wouldn’t necessarily develop but you have to know what you can expect:
- Dryness of the oral mucosa;
- Nausea and even vomiting;
- Anorexia (loss of appetite);
- Taste disturbance;
- Diarrhea or constipation;
- Inability to urinate;
- Sight violation;
- General weakness;
- Flushes;
- Noise in the ears;
- Headache;
- Sleepiness;
- Hallucinations;
- Extrapyramidal symptoms;
- Tremor;
- Blood pressure lowering;
- Allergic reactions (skin rash, itching, angioedema, swelling, etc.)
- Lowered or enhanced libido;
- Enlargement of the mammary glands;
- Testicles swelling and others.

Please be informed that if you already have any conditions, for instance, prostatitis, gastritis, and o on, you are more likely than other patients to develop the adverse effects from the side of the organ that is ill.

Incidence of treatment-emergent adverse reactions (% of patients)

Adverse reactions
Placebo
(n=1456)
Sinequan (Doxepin)
(n=1405)
Somnolence
2%
3%
Fatigue
2%
3%
Dizziness
3%
4%
Nausea
2%
3%
Insomnia exacerbated
2%
3%

What are the dosage regimens of Sinequan?

It is preferable to follow the doctor’s order when you buy generic Doxepin and have this instruction for information only or as a reminder of how the medicine should be taken if you are prescribed to take it as indicated in the label:
- The regular daily dosage is between 30 and 300 mg. The dose at the beginning of the therapy is 15-25 mg with the following dosage raise till the effective dosage if necessary. If the daily dose is 100 mg or lower, it can be taken without splitting. The higher dosages have to be split into three intakes. The maximum per intake dosage is 100 mg taken before sleep.
In mild to moderate symptoms, the advised dosage is 75 mg daily. In the majority of cases, this dosage is deemed sufficient. In severe cases, the dosage can be raised to 300 mg split into 2-3 intakes.
- The daily doses for kids aged more than 12 years are chosen in accordance to their body weight with the standard dosage of 0,5 mg per kilogram of weight.
The duration of the therapy is chosen individually. Usually, the symptoms of anxiety fade away during the first or second weeks of the therapy while the depression symptoms are usually gone within two to three weeks.

Dosage adjustments for separate groups of patients

Senior patients with moderate symptoms of the disorders treated with the formulation should take a half of the regular dosage of the medicine which is around 10-50 mg daily.
People with impaired liver or kidney function should take the lower dosages.
Interactions of Sinequan

When you order Sinequan, you should know that its effect can be affected by the use of other substances:
- The prohibited substances that must be avoided during the therapy are MAO inhibitors and alcohol.
- The level of the medication is elevated and the effect enhanced in the simultaneous use with Cimetidine.
- People with diabetes who use Tolazamide can develop severe hypoglycemia (a decrease in the concentration of glucose in the blood below 3.5 mmol/l).
- Chlorpromazine increases the likelihood of hyperpyrexia (extremely high body temperature).

Overdose of Sinequan

If you take a significantly increased dosage of Sinequan or a generic version of the medicine, you can develop sleepiness, stupor, hallucinations, vision impairment, dilated pupils, dry mouth, slow breathing low blood pressure, seizures, heart symptoms, and even coma.
An overdose of tricyclic antidepressants it very dangerous and should be treated seriously with the seeking of emergency help or at least calling a poison helpline for the instructions on how to cope with the symptoms. The measures that should be implemented include discontinuation of the medicine use, gastric lavage, artificial lungs ventilation, and control over the cardiovascular system; in seizures occurrence, a standard anti-seizure therapy should be implemented.

Precautions to follow when you buy Sinequan

- In the long-term therapy, the abrupt discontinuation of the medicine use can cause withdrawal syndrome with nausea, headache, general weakness, and so on.
- During the therapy, it is not advised to engage in any activity that requires the fast speed of mental and motor reactions.
- During the therapy, the use of alcohol is contraindicated.
- People who have accompanying disorders, are aged older than 65, or take any medicines besides this antidepressant are recommended to take the daily dosage in one intake.
- Patients over 65 are prone to the development of anxiety, confusion, and orthostatic hypotension (darkening in the eyes when standing up). Thus, they require lower dosages and cautious dosage adjustment under a doctor’s supervision and thorough control over the condition and reaction of the patient. Most of the time a half of the regular dosage is able to provide a sufficient effect.
- Patients who order Doxepin should know that the medication can provoke sleepiness and if combined with alcohol, this negative effect is only aggravated.
- In case of aggravation of symptoms of psychosis or manic episodes during the therapy, a lowering of the dosage or addition of neuroleptics to the therapy can be required.
- Although Doxepin’s effect on the cardiovascular system is milder than the effect of other tricyclic antidepressants, it must be taken cautiously by people with severe cardiovascular conditions (AV block, arrhythmia, myocardial infarction).
- People with suicidal tendencies must be thoroughly monitored during the entire therapy course of the therapy. Patients or their caregivers or family members must be informed that they should inform the healthcare provider who prescribed the therapy in any mood or behavior changes of the patient.

Where can you purchase Sinequan?

The medication is available both at the regular and online pharmacies but the cost of the treatment course is different. If you want to get the medication cheaper – order generic Doxepin from this webpage and we will provide you with a free doctor consultation, free prescription, and a discount for your next order.

Shipping of Sinequan

We operate internationally including the U.S., UK, EU, and so on. The time of delivery is from 7 to 30 days based on the method of delivery you select while finalizing the order.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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