Generic Medication guide:
What is the medication sold as Ceftin?
Ceftin is one of the trademarks under which a second-generation cephalosporin antibiotic also known under other names such as Aksetin, Zinnat, Zinatsef, and others is sold. The active agent of the medication is Cefuroxime. Besides the different names, the same formulation can have different prices that depend on the manufacturer and the region where the pills are marketed. If you need to buy Ceftin but don’t want to overpay for the known brand, look for generic version instead.
The formulation is a bactericidal agent (killing bacteria) of the wide spectrum. It inhibits the transpeptidase, disrupts the biosynthesis of the mucopeptide of the cell wall of microorganisms which kills the pathogens that cause bacterial diseases.
Ceftin is effective against a wide range of pathogens and is stable in the impact of the majority of beta-lactamases, the enzymes produced by bacteria as a self-defense mechanism. It makes the formulation efficient against the bacterial pathogens insusceptible to Ampicillin and amoxicillin.
Clinical data
|
Trade names |
Zinacef, Ceftin |
Pregnancy category |
B |
Routes of administration |
Intramuscular, intravenous, oral |
Legal status
|
Legal status |
In general: RX (Prescription only) |
Pharmacokinetic data
|
Bioavailability |
37% on an empty stomach, up to 52% if taken after food |
Elimination half-life |
80 minutes |
Excretion |
Urine 66-100% unchanged |
When is Ceftin utilized?
The medicinal product use is appointed for the elimination of the infections conditioned by the sensitive pathogens. These conditions include:
- Diseases of the upper and lower airways such as bronchitis, pneumonia, pleural empyema, etc.
- Inflammatory illnesses of the middle ear, throat, nose, epiglottitis, and other diseases treated by an otolaryngologist.
- Inflammation of the urethra and kidneys, cystitis, gonococcal urethritis, and cervicitis.
- Infections of the skin.
- Bone and joints infections;
- Infections of the pelvic organs including endometritis, adnexitis, and cervicitis.
- Infectious illnesses of the biliary tract and digestive tract, sepsis, bacterial septicemia, peritonitis, meningitis, Lyme disease;
- Prevention of infectious complications in surgeries.
If your diagnosis is one of the diseases listed, remember, you can buy generic Ceftin without Rx from this webpage but we highly encourage you to purchase the medication only when your doctor prescribes it to you knowing your medical history, allergies, and so on.
Ceftin contraindications
You must not use the medication because it can be harmful to you if you have:
- Sensitivity manifested in adverse effects and allergies to cephalosporin antibiotics, Ceftin or other components of the pills.
- History of severe sensitivity reactions to any beta-lactam antibiotic of other types, for instance, penicillins, monobactams, and others.
The formulation is also not advised but still can be used but only after an attending doctor approval for:
- Newborns;
- Prematurely born babies;
- People with chronic kidney failure;
- Patients who have a history of bleedings and digestive tract disorders including nonspecific ulcerative colitis.
- Weak and depleted patients.
Formulation use during gestation and lactation
The medication can but must be carefully used by women who expect babies especially at the early gestation stages.
As for breastfeeding, it is advised to opt for bottle-feeding at the time of the therapy.
Adverse effects of Ceftin
Individuals who have been prescribed the therapy with the formulation, before they buy Cefuroxime may find it useful to find out what negative effects the therapy can be associated with:
- Headache, sleepiness, hearing deterioration;
- Low hemoglobin, leukopenia, aplastic and hemolytic anemia, thrombocytopenia, agranulocytosis, hypoprothrombinemia, extended prothrombin time, and other blood disorders.
- Diarrhea, nausea, constipation, cramps, and pain in the abdomen, indigestion, mouth ulcers, loss of appetite, thirst, colitis, hepatitis, liver diseases, and others;
- The function of the kidneys impairment, increase of creatinine and/or urea in the blood serum, decreased creatinine clearance, dysuria (inability to urinate), pruritus (groin itching), and vaginitis;
- Allergy manifested in skin rash, itching, urticaria, fever, multiform erythema, Stevens-Johnson syndrome, anaphylaxis, and others.
Other possible negative events that can be associated with the pills are the pain in the chest, shortening of the breath, dysbiosis (dominance of bad flora over the good one in the intestines), superinfection, candidiasis, incl. candidiasis of the oral cavity, convulsions, positive Coombs test.
Ceftin dosing
The usual treatment with the formulation is seven days but can be also from five to ten days.
For the best work of the formulation within the body, it must be taken after meals.
The following dosages are provided in the official instruction for patients (both adults and kids) with the body mass over 40 kg:
- Acute infections of the throat and nose – 500 mg taken in two equal intakes;
- Middle ear inflammation – 1000 mg taken in two equal intakes;
- Chronic bronchitis flare-up – 1000 mg taken in two equal intakes;
- Cystitis, pyelonephritis - 500 mg taken in two equal intakes;
- Infections of the skin - 500 mg taken in two equal intakes;
- Lime disease - 1000 mg taken in two equal intakes (the therapy can last from ten to twenty-one days and on average is two weeks);
Dosages for kids with the body mass under 40 kilograms:
- Acute infections of the throat and nose – 10 mg per kg of the body weight taken twice a day. The highest safe dose is 250 mg split into two intakes a day.
- Middle ear inflammation or other severe infections – 15 mg per kg of the body weight taken twice a day. The highest safe dose is 500 mg split into two intakes per day.
- Cystitis, pyelonephritis - 15 mg per kg of the body weight taken twice a day. The highest safe dose is 500 mg split into two intakes per day. The therapy of kidney inflammation can last 10-14 days.
- Infections of the skin – 15 mg per kg of the body weight taken twice a day. The highest safe dose is 500 mg split into two intakes per day.
- Lime disease - 15 mg per kg of the body weight taken twice a day. The highest safe dose is 500 mg split into two intakes per day. The therapy can last from 10 to 21 days and on average is 14 days.
Dosage adjustments
The formulation is washed out of the body by the kidneys. Individuals with severe kidney function impairment the recommended dosages must be cut in two or taken with greater intervals to compensate for its slow washing out.
- Patients with cc higher than 30 ml per minute do not require dosage alterations;
- Patients with cc from 10 to 29 should take the standard dosage every 24 hours;
- Patients with cc lower than 10 ml per minute should take the standard dosage every 48 hours;
- Patients of hemodialysis should take a single standard dosage after every dialysis session.
Concentrations of Cefuroxime achieved in cerebrospinal fluid during multiple dosing of patients with meningitis
Patients
|
Dose
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Number of Patients
|
Mean (Range) CSF Cefuroxime Concentrations (mcg/mL) Achieved Within 8 Hours Post Dose
|
Pediatric patients (4 weeks to 6.5 years)
|
200 mg/kg/day, divided q 6 hours
|
5
|
6.6 (0.9-17.3)
|
Pediatric patients (7 months to 9 years)
|
200 to 230 mg/kg/day, divided q 8 hours
|
6
|
8.3 ( < 2-22.5)
|
Adults
|
1.5 grams q 8 hours
|
2
|
5.2 (2.7-8.9)
|
Adults
|
1.5 grams q 6 hours
|
10
|
6.0 (1.5-13.5)
|
Susceptibility test interpretive criteria for Cefuroxime
Pathogen
|
Minimum Inhibitory Concentrations (mcg/ml)
|
Disk Diffusion Zone Diameters (mm)
|
(S) Susceptible
|
(I) Intermediate
|
(R) Resistant
|
(S) Susceptible
|
(I) Intermediate
|
(R) Resistant
|
Haemophilus influenzae |
>= 4
|
8
|
>=16
|
>=20
|
17-19
|
<=16
|
Enterobacteriaceae* |
<=8
|
-
|
>=16
|
>=18
|
-
|
<=17
|
Neisseria gonorrhoeae |
<=1
|
2
|
>=4
|
>=31
|
26-30
|
>=25
|
Streptococcus pneumoniae |
<=0.5
|
1
|
>=2
|
-
|
-
|
-
|
Overdose of Ceftin
An overdose of this antibiotic is fraught with neurological complications such as encephalopathy, seizures and even coma. The symptoms of an overdose are likely to occur in patients with kidney dysfunction if the dosages or intake regimen for them hadn’t been adjusted.
The level of the formulation in the blood can be lowered through hemodialysis and peritoneal dialysis.
Ceftin interactions
When you buy generic Cefuroxime you must check that you don’t use any medications or other substances that can negatively interact with the medication. Below you can find the list of such substances.
- Medicines that low stomach acidity can diminish the bioavailability of the antibiotic and liquidate the improved absorption of the medication when taken after a meal.
- As other antibiotics, Ceftin can cause an imbalance in the intestinal flora and cause impaired reabsorption of estrogens and thus the effectiveness of combination oral contraceptives.
- Since a false-negative result can be observed in a ferrocyanide test so other tests are recommended.
- The concurrent use of the antibiotic with Probenecid significantly lowers the level of the antibiotic thus it is encouraged not to combine these medicines.
- The concurrent use of the antibacterial medication with oral anticoagulants can cause significant coagulation time extension.
- The level of Cefuroxime in the blood level can be lowered by hemodialysis.
Ceftin precautions
- If you order Ceftin for a long-duration therapy, it is encouraged to regularly do the liver function tests especially in the use of high doses and do a prophylaxis of dysbiosis (imbalance of the intestinal flora).
- People who are intolerant to penicillins can have allergic reactions with cephalosporin antibiotics;
- After the signs of the disease are eliminated, the therapy with the antibiotic must be continued for 2-3 days. In the disease caused by Streptococcus pyogenes, the therapy must be not shorter than 7-10 days.
- Urine sugar tests can be false-positive during the therapy.
Where to buy Ceftin?
The optimal way to get the medication cheaper for a patient who lives in the county where it is sold with Rx exclusively is to order generic Ceftin online from our med store.
Generic Ceftin shipping
You can without any worries place your order and rest assured that you will receive your parcel wherever you live in 7-25 days (based on selected delivery method).
Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section
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