Generic Medication guide:
Treating HIV virus in America can be very expensive. The most effective modern medications are incredibly overpriced. Moreover, even preventive therapy usually requires the use of several drugs for the best results as a monotherapy is proven to be unsuccessful.
On the other hand, today’s medications are quite effective. They not only significantly increase survival rates but also help people infected with HIV live a full life without being stigmatized or suffering from additional illnesses. The drugs even help patients with the diagnosis to be able not to infect their sexual partners with the virus. Yes, the treatment is very expensive and not in all countries its cost is covered by the insurance or government health care. But the good news is that you can yourself buy the needed medications cheaper than they are sold by your local drugstores. In order to enjoy this possibility, you need to buy Generic Zidovudine (Retrovir) online.
Our online drugstore offers you a wide range of antiviral medications, so-called generics, which are made in compliance with the original formulas and based on the same substances as the expensive brand-name medications. These drugs are sold cheaper because they are produced under a license from the original drug developer sold to the other pharmaceutical companies. Such companies do not invest in research but purchase licenses and formulas and are able to sell the same drugs cheaper. Such practice is approved by the World Health Organization and is even encouraged. It allows people with lower income, citizens of developing or underdeveloped countries to have access to the most effective, innovative medications at affordable cost.
Now, before you buy Generic Zidovudine (Retrovir) online, read our medications guide to know all information you need about the drug you plan to use.
History of Generic Zidovudine (Retrovir)
Zidovudine was synthesized in 1964 by Jerome Horwitz during the research on the theory about the viral nature of cancer that became popular after the discovery of the connection between the development of cancerous tumors in birds with retrovirus by Nobel laureates Howard Temin and David Baltimore. But the development of Zidovudine was stopped at that point due to the biological inertia shown in mice with leukemia.
In 1974 during the clinical trials, it was discovered that the drug is effective against retrovirus in mice. After clinical trials conducted in 1985 and proved effectiveness of the drug in the fight against HIV, Zidovudine has been widely used.
Zidovudine is the first antiretroviral drug to hit the market in 1987. Already in very early studies of Zidovudine, it was found that monotherapy with Zidovudine significantly improves survival, at least in severe immunodeficiency. Nevertheless, during the early research, the statistically significant effect of Zidovudine on the survival of patients with asymptomatic HIV infection wasn’t proven. It made the researchers conclude that the medication is not very effective as a monotherapy.
It has been proven though that Zidovudine is very effective when used in combination with other antiretroviral drugs. In the 1990s, the combination of Zidovudine and Lamivudine was one of the most commonly used for HIV treatment. Zidovudine has been studied in numerous clinical trials, and its use has accumulated the most extensive experience in comparison with all other medications (over 20 years). Nevertheless, it is currently considered not the best choice for the first-line therapy because of the frequent occurrence of severe side effects and need to take the medication two times a day in comparison with a single daily intake of modern medications.
However, Zidovudine continues to be in included in some regimens to prevent HIV transmission from a mother to a child and as a part of post-exposure prophylaxis because the benefits of its use in these particular cases have been proven. It is especially beneficial to use the drug in such schemes because it shows good statistics in the effect on the mutated virus. For example, the strains with mutations K65R or M184V are hypersensitive to Zidovudine. Additional advantages of Zidovudine are the absence toxic effect on the central nervous system and good penetration through the blood-brain barrier.
The exclusive patent for Zidovudine production in the U.S. expired in 2005. It means that today, the drug is available at much lower cost if you buy Generic Zidovudine (Retrovir).
How Generic Zidovudine (Retrovir) used now?
Currently, the medication is used both for HIV treatment and prevention. It is commonly used in a daily dosage divided into two intakes along with other antiretroviral drugs. This treatment method is referred to as Highly Active Antiretroviral Therapy. It is used also as the prevention of HIV resistance to the suppressing therapy.
The drug is also used as a pre-exposure prophylaxis and post-exposure treatment of mother-to-child transmission of HIV during pregnancy, labor, and delivery. During 20 years of research, it had been proven that without the prophylaxis therapy, around 15% of fetuses of HIV-infected mothers gets infected.
How Generic Zidovudine (Retrovir) acts?
The medication inhibits a specific HIV's enzyme that the virus uses to make a DNA copy of its RNA.
Does Generic Zidovudine provide the same effect as the brand-name drug?
Yes, the medications are identical. The generic versions of the drug are made in accordance with the original formula and are based on the same ingredients. It is possible because the exclusive patent of the inventor expired and because there is a policy set by the World Health Organization that all medications from the List of Essential Medicines must be available in form of cheaper generics to be affordable for people from developing and underdeveloped countries.
How Generic Zidovudine (Retrovir) should be used?
It doesn’t matter whether you use the brand medication or generic Zidovudine - the standard dosage would be the same.
The medications are made in capsules by 100 and 300 mg, oral suspension by 200 ml (50 mg of the active substance in 5 ml of solution), and infusion solution by 20ml with 200 mg dosage per vial.
The daily dosage is 600 mg a day taken in 2 or 3 intakes. If you undergo therapy at home, you need to buy Generic Zidovudine (Retrovir) 100 mg or 300 mg capsules and take either two 100 mg capsules 3 times a day or one 300 mg capsule two times a day.
Whom the drug is contraindicated?
The medication is contraindicated for people with hypersensitivity to the medication, leukopenia (neutrophil count less than 750x109/liter), and anemia (hemoglobin less than 70 g/liter).
What side effects can the drug cause?
The most significant side effects the drug can cause are: at the beginning of the therapy (6-8 weeks) – dizziness, fatigue, loss of appetite, nausea, and vomiting. The adverse reactions that occur during the long duration treatment are anemia, skin itching, and muscle pain.
Another aspect that can be unnoticeable to the patient but should be attentively monitored by the doctor is that the medication has a toxic effect on the bone marrow. Therefore, the patients who are treated with Zidovudine need to have general blood tests so the doctors can stop the therapy if there is a danger of serious harm to the body if the erythrocyte count is unacceptable for the condition.
Where can you buy Generic Zidovudine (Retrovir)?
You can buy the brand-name medication at your local drugstores if you have Rx medication from your doctor or you can buy Generic Zidovudine (Retrovir) from our online pharmacy much cheaper and even without a prescription. Though, naturally, it is better to purchase the medication only if your doctor tells you to do so and gives you precise instructions on how to use it and for how long.
Interactions of Generic Zidovudine with other medications and food
The drug can be taken without regard to meals though fat food can slow down its absorption.
The medication is incompatible with Stavudine. The combination with Ribavirin can be ineffective. The toxic effect on the bone marrow is amplified when the drug is used along with ganciclovir, vincristine, amphotericin B, cytostatics, and other drugs depressing marrow. The combination of Zidovudine with paracetamol increases the risk of neutropenia (abnormally low count of a certain type of white blood cells).
Methadone significantly increases the concentration of the active substance in plasma (by 30-40%), which may increase the risk of Zidovudine side effects occurrence.
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section