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4RX Store > Medication List > Arthritis drugs > Order Arcoxia online

Arthritis Medication (Arcoxia)

 
Generic name:
Arcoxia
Brand name:
Etoricoxib
Description:
Arcoxia is the brand used for Etoricoxib, a NSAD with a selective action that has a lower harmful effect on the digestive system than other NSAIDs. The formulation is used for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, and postoperative pain. The therapy with the pills must be a short-term one as the longer is the therapy, the higher is the risk of cardiovascular adverse effects. Find out how to use it safely from our med guide.
Indications:
Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute gouty arthritis, Postoperative pain
Benefits:
The medication quickly eliminates the symptoms of join and bon diseases
Manufacture:
Cipla - Caring for life
Cipla - Caring for life

Intas Pharmaceuticals Ltd.
Intas Pharmaceuticals Ltd.
Synonyms:
Etori, Etoshine, Etozox
 
   
Arcoxia (Generic Etoricoxib)
 
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  Generic Medication guide:

What is Arcoxia and when is it used?

Arcoxia is a brand owned by the American pharmaceutical company Merck & Co. It is registered for the medication from the class of nonsteroidal anti-inflammatory drugs that target cyclooxygenase-2, the enzyme produced in the body that is responsible for inflammatory processes and pain. The active agent of the formulation is called Etoricoxib. It is the name of the medicinal substance you can find on the packages of the drugs marketed under other names. These medicines are called generics of Arcoxia. They are marketed under other names but there is always the name Etoricoxib under the trade name. These medications are cheaper than the branded one so if your doctor tells you to buy Arcoxia, look for generic instead to save your money.

The formulation selectively inhibits cyclooxygenase-2 and has a painkiller, anti-fever, and anti-inflammatory effects. The advantage of this medication is that it doesn’t affect the mucosa of the stomach and the rest of the digestive tract like other NSAIDs do. The anti-inflammatory effect of the formulation is related to the diminished vascular permeability, improved blood circulation, minimized production of inflammation intermediaries from cells, and stopping of the energy supply for the inflammation site.

Property Name
Property Value
Molecular Weight
358.84 g/mol
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
3
Complexity
514
Topological Polar Surface Area
68.3 A^2
Monoisotopic Mass
358.054 g/mol
Exact Mass
358.054 g/mol
XLogP3-AA
3.3
Compound Is Canonicalized
true
Formal Charge
0
Heavy Atom Count
24
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Isotope Atom Count
0
Covalently-Bonded Unit Count
1

The formulation is appointed for the symptomatic therapy of various types of arthritis:
- Osteoarthritis,
- Rheumatoid,
- Ankylosing spondylitis,
- Acute gouty arthritis.

If you are diagnosed with one of these conditions, you can buy generic Arcoxia at this webpage but we would recommend you to consult a specialist who will appoint you the whole therapeutic course that can involve also the use of other formulations for a comprehensive effect.

Drug information
Pregnancy
category
Not recommended
Routes of
administration
Oral
Legal status
Legal status AU: S4 (Prescription only)
UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability 100%
Protein binding 92%
Metabolism Hepatic, CYP extensively involved (mainly CYP3A4)
Elimination half-life 22 hours
Excretion Renal (70%) and fecal (20%)

Arcoxia contraindications

The use of the formulation is prohibited in:
- Elevated sensitivity to the main active or auxiliary substances of the drug;
- Peptic stomach ulcer or gastric or intestinal hemorrhage;
- In the previous bronchospasm, rhinitis, angioedema, urticaria, or other allergic reactions as a response to the use of aspirin or NSAIDs including COX-2 inhibitors;
- Pregnancy or breastfeeding;
- Severe liver failure;
- Kidney failure with creatinine clearance less than 30 ml per minute;
- Children younger than sixteen years;
- Severe diseases of the intestines;
- Congestive heart failure;
- Arterial hypertension with the chronically raised arterial pressure of 140/90 mm Hg;
- Coronary artery disease, peripheral arterial illness and/or the disorder of brain blood circulation.

The safety of the use of the formulation must be estimated by a doctor in the presence of the following factors:
- Ulcerative gastrointestinal lesions in the past;
- Helicobacter pylori presence;
- Prolonged use of NSAIDs;
- Frequent use of alcohol;
- Severe physical illnesses;
- Dyslipidemia/hyperlipidemia;
- Diabetes;
- Elevated arterial pressure;
- Swelling;
- Smoking;
- Kidney failure (cc lower than 60 ml per minute);
- Use of anticoagulants, antiplatelet agents, oral glucocorticoids, selective serotonin reuptake inhibitors;
- Senior age.

Arcoxia dosing

The tablets are used by mouth regardless of meals but the effect of the formulation starts to manifest quicker in the use on an empty stomach.

Since the risk of heart and vessels disorders is higher in the extended use of the formulation, it is advised to use it for short periods of time in the minimum effective dosages.
- Osteoarthritis symptoms are managed with 30 mg a day. In some individuals, the riddance of the disease manifestations requires the use of 60 mg a day. If there are no positive results, the therapy must be revised.
- Rheumatoid arthritis is managed with 60 mg a day. In some individuals, the riddance of the disease manifestations requires 90 mg a day. Once the stabilization of the symptoms is achieved, the dose must be lowered to 60 mg. If there are no positive results, the therapy must be revised.
- Ankylosing spondylitis is managed with 60 mg a day. In some individuals, the riddance of the disease manifestations requires 90 mg a day. Once the stabilization of the symptoms is achieved, the dosage must be lowered to 60 mg. If there are no positive results, the therapy must be revised.
- Acute pain is managed with the medication only in the acute period.
- Acute gouty arthritis is managed with 120 mg a day.
- Postoperative pain is managed with 90 mg a day for the maximum period of 3 days.
The dosages higher than the recommended ones either are not more effective or hadn’t been studied. Thus, the maximum dosages are the following:
- Osteoarthritis - 60 mg a day;
- Rheumatoid arthritis and ankylosing spondylitis - 90 mg;
- Acute goat - 120 mg for the maximum period of 8 days;
- Acute postoperative pain – 90 mg for the maximum period of three days.

Dosage adjustments

Patients older than 65 years do not need dosage adjustments but the treatment must be made with caution.

Regardless of the disease treated, the daily dosage for patients with mild kidney failure must not exceed 60 mg. The dosage per day for individuals with moderate kidney failure must not exceed 30 mg.

Patients with liver failure of mild to moderate severity must use the medication cautiously. Patients with liver failure of the severe stage must not use the medication.

Arcoxia adverse effects

When you buy Etoricoxib and start the therapy you can develop the following negative symptoms:
- Headache, dizziness, weakness, taste perversion, sleepiness, sleep disorder, anxiety, depression, inability to focus, blurred vision, hallucinations, and others;
- Rapid heartbeat, impaired cerebral blood flow, myocardial infarction, blood disorders, and others;
- Coughing, wheezing, nasal bleeding, infections of the upper respiratory tract;
- Nausea, diarrhea, indigestion, bloating, pain in the abdomen, liver dysfunction, constipation, dry mouth, gastritis, hepatitis, and others;
- Infections of the urinary tract;
- Muscle cramps, myalgia;
- Skin rash, skin itching, urticaria, and others;
- Flu-like syndrome, swelling, water retention in the body, chest pain, increased body mass.

Arcoxia overdose

The overdose of the formulation is fraught with the enhancement of adverse effects from the part of the digestive system, kidneys, and cardiovascular systems.
The required treatment is aimed at the elimination of occurred symptoms.

Arcoxia interactions

Before you buy generic Etoricoxib, make sure to check that medication doesn’t negatively interact with the drugs you use if you use any. Here you can find the most notable interactions but for the whole list, you must see the package insert.
- Oral anticoagulants taken along with Arcoxia can cause a significant increase of the prothrombin time, i.e. blood coagulation time. Thus, people who use these medications together must b monitored for prothrombin time especially during the first days of the therapy with Arcoxia.
- Arcoxia, as well as other NSAIDs, can lower the effect of diuretics and antihypertensive medications.
- The use of Etoricoxib can enhance the toxic effect on the kidneys of Cyclosporine and tacrolimus so kidney function must b monitored in the use of these medications.

Arcoxia precautions

When you order Arcoxia, keep in mind that the longer the medication is used the higher is the risk of severe cardiovascular thrombotic complications, including myocardial, with the possible fatal outcome.

The use of the formulation can cause severe negative reactions on the part of the digestive system such as hemorrhages, ulceration, and others. The risk is elevated in senior patients and in long-term use of the formulation.

During the first wks of the therapy, the control over the arterial pressure is needed. It is necessary to control the liver and kidney function and discontinue the therapy in case of substantial deviations.
It is not encouraged to use the formulation and drive or operate any machinery.

Where to buy Arcoxia?

The cheapest option is to order generic Arcoxia from our med store. We offer a generic version of the formulation which is the same as the branded but costs cheaper.

Arcoxia shipping

Our pharmacy ships all of the medications we sell internationally via standard and express mail in 7 to 24 days.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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