Generic Medication guide:
What is Foradil and when is it utilized?
If your physician or asthma-therapy specialist tells you to buy Foradil, you should know that it is one of the trade names of the ingredient Formoterol. The trademark Foradil is owned by a Swiss drug-making company Novartis but exactly the same formulation is made by other firms too and sold cheaper as a generic version, i.e. you can ask any pharmacist or look on the Internet for generic Foradil and you will get the medicinal product with the main ingredient Formoterol.
Short drug information
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Trade names |
Foradil/Foradile, Oxeze/Oxis, Atock (Astellas), Atimos, and others |
Pregnancy category |
AU: B3
US: C (Risk not ruled out) |
Routes of administration |
Inhalation (capsules for oral inhalation, DPI, MDI) |
Legal status
|
Legal status |
UK: POM (Prescription only)
US: (Prescription only)
In general: (Prescription only) |
Pharmacokinetic data
|
Protein binding |
61% to 64% |
Metabolism |
Hepatic demethylation and glucuronidation
(CYP2D6, CYP2C19, CYP2C9 and CYP2A6 involved) |
Elimination half-life |
10 hours |
Excretion |
Renal and fecal |
Formoterol is an extended-action agonist of adrenergic beta-2 receptors. When inhaled, it acts locally on the bronchi inducing their dilation and thus alleviating breathing. The action of the agent towards the receptors in the bronchi is more than 200 more intense than towards the same receptors in the myocardium which makes the medication safe for use.
The indications for the inhaler use are:
- Therapy of asthma and prevention of suffocation attacks in obstructive diseases of the airways including the patients with the symptoms of night asthma.
- The use as required for the avoidance of suffocation induced by physical activity.
- Long-term maintenance therapy of COPD, chronic bronchitis, and lung emphysema.
You must acknowledge that for the same conditions different medications can be used at a doctor’s discretion and depending on the accompanying diseases and symptoms. Only a specialist can choose the correct medication and dosage regimen so you must get examined and consulted by a respiratory specialist before you buy generic Foradil notwithstanding that you can get it without Rx from our pharmacy.
Foradil use contraindications
The use of the inhaler is prohibited for people with hypersensitivity to its components and other beta-2 receptors stimulants.
The other contraindications are:
- Tachyarrhythmia,
- Third-degree blockade,
- Aortic stenosis,
- Obstructive cardiomyopathy,
- Thyrotoxicosis,
- QT interval extension.
The inhaler can be used but with caution in individuals with any other cardiovascular diseases including arrhythmia, high arterial pressure, as well as in seizures, pregnancy, breastfeeding, and in children under five years.
The use of the product is considered unreasonable for patients whose asthma is controlled by the non-systematic inhalation of quick-acting beta 2-receptors stimulants or inhaled steroids or other medications one of which is a short-acting beta 2 adrenergic agonist used from time to time.
Foradil way of using and dosing
To know how to use the device use for inhalations, read the package insert or better consult a respiratory specialist if you haven’t been using any inhalers before. Here we provide the information based on the official dosing guidelines from the package insert.
Adults, senior patients, and kids older than 12 years
- Bronchial asthma: the supporting therapy is made with a single inhalation twice a day. In the conditions, it can be elevated to two inhalations two times a day. The highest daily dosage is four inhalations.
- COPD: the regular supporting therapy is made with a single inhalation twice a day. The highest daily dosage is two inhalations.
Kids 6-12 years
- Bronchial asthma: the regular supporting therapy is made with a single inhalation two times a day. The highest daily dosage is two inhalations.
The effect of the formulation is maintained within twelve hours but if an acute bronchospasm occurs within this time a quick-acting inhaler must be utilized.
It is advised to use the lowest effective dosage.
Dosage adjustments
There is no information on the medication use impaired liver of kidney function. However, since the active agent of the medication is excreted via the liver, the rise of its level in the blood can be expected in severe liver cirrhosis.
Overdose
There is a little information on the overdose of the formulation but it can be assumed that in a use of a significantly higher dosage the adverse effects alike from other beta-2 receptors agonists can occur such as tremor, headache, rapid heartbeat, arrhythmia, nausea, and vomiting.
The treatment implies the measures aimed at the reduction of the symptoms and in severe cases hospitalization is required.
Adverse effects
When you buy Formoterol you can develop the following adverse effects:
- Tremor;
- Dizziness;
- Sleeplessness;
- Bronchitis;
- Infections of the chest organs;
- Tonsillitis;
- Ache in the chest, and others.
In the onset of an allergic reaction such as rash, itching, swelling, or a bronchospasm associated with the use of the inhaler, the use of the formulation must be immediately discontinued and another therapy chosen by a doctor.
Interactions with other medicines
- Other adrenergic agonists can potentiate the risk of adverse effects of Formoterol.
- The simultaneous use of the inhaler with xanthines, steroids or water pills can amplify the hypokalemic effect (low potassium).
- Hypokalemia and changes in the electrocardiogram can aggravate in the use of the inhaler especially in the use of the high doses.
- The inhaler, as well as other adrenergic agonists, must be cautiously used along with MAO inhibitors, tricyclic antidepressants, other medicinal substances able to extend the QT interval as it can cause heart function disturbance.
- Formoterol and beta blockers suppress each other’s the effects. Besides, their combined use can contribute to the development of bronchospasm.
Discuss with a medical practitioner the possibility of combining the inhaler with other meds before you buy generic Formoterol if you take any medications.
Precautions and special recommendations for the inhaler use
In case of an acute asthma attack during the therapy with the inhaler short-acting bronchodilators must be used. The inhaler is not designed to render emergency help in an asthma attack.
Formoterol can be added to the therapy with inhalation steroids if their effect is insufficient but patients must be informed that one inhaler doesn’t replace another but only supplements it. The medication doesn’t have the anti-inflammatory effect so it cannot replace corticosteroids.
If the symptoms are the same or even aggravate during the inhaler use, it means that the therapy must be revised by a doctor.
When a patient is transferred to Formoterol from other inhalers, the scheme of treatment must be chosen individually taking into account the prior therapy, dosing regimen and method of application.
If the use of the inhaler provoked bronchospasm, it must be immediately stopped to be used and an alternative treatment plan chosen.
Number and frequency of adverse reactions in users older five years from multiple-dose controlled clinical trials of more than one month use
Body System/ Adverse Event (Preferred Term)
|
FORADIL
CERTIHALER
10 mcg twice daily
|
Placebo
|
n
|
(%)
|
n |
(%)
|
Total Patients |
414
|
(100)
|
416
|
(100)
|
Nasopharyngitis |
34
|
(8.2)
|
24
|
(5.8)
|
Headache NOS |
34
|
(8.2)
|
33
|
(7.9)
|
Upper respiratory tract infection NOS |
33
|
(8.0)
|
31
|
(7.5)
|
Cough |
21
|
(5.1)
|
17
|
(4.1)
|
Pyrexia |
19
|
(4.6)
|
11
|
(2.6)
|
Vomiting NOS |
15
|
(3.6)
|
7
|
(1.7)
|
Tremor |
11
|
(2.7)
|
2
|
(0.5)
|
Nasal congestion |
10
|
(2.4)
|
8
|
(1.9)
|
Rhinitis allergic NOS |
10
|
(2.4)
|
1
|
(0.2)
|
Viral infection NOS |
10
|
(2.4)
|
5
|
(1.2)
|
Influenza |
9
|
(2.2)
|
4
|
(1.0)
|
Bronchitis NOS |
9
|
(2.2)
|
2
|
(0.5)
|
Upper respiratory tract infection viral NOS |
7
|
(1.7)
|
4
|
(1.0)
|
Back pain |
7
|
(1.7)
|
4
|
(1.0)
|
Conjunctivitis |
6
|
(1.4)
|
2
|
(0.5)
|
Rash NOS |
6
|
(1.4)
|
0
|
0
|
Dyspepsia |
6
|
(1.4)
|
2
|
(0.5)
|
Pharyngitis streptococcal |
5
|
(1.2)
|
3
|
(0.7)
|
Urinary tract infection NOS |
4
|
(1.0)
|
3
|
(0.7)
|
Diarrhea NOS |
4
|
(1.0)
|
3
|
(0.7)
|
Bronchitis acute NOS |
4
|
(1.0)
|
1
|
(0.2)
|
Respiratory tract infection |
4
|
(1.0)
|
1
|
(0.2)
|
Muscle cramps |
4
|
(1.0)
|
1
|
(0.2)
|
Insomnia |
4
|
(1.0)
|
2
|
(0.5)
|
Asthma NOS |
4
|
(1.0)
|
3
|
(0.7)
|
Where can you buy Foradil cheap?
You probably know that generic versions of the medications, i.e. the same medicines under other names, are significantly cheaper. Thus, if you need the branded product, you can instead order generic Foradil at our online pharmacy and get the same product at a fraction of price.
Foradil shipping
We provide our customers with shipping all over the world. We ship Foradil to the U.S., UK, and other countries within 7-25 days (express/standard mail service). You can enjoy free standard shipping if you are not in a hurry when you order any products for $170 or more.
Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section
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