Generic Medication guide:
What is the medication sold under the name Lotensin?
Lotensin is a brand of the Swiss pharmaceutical company named Novartis. The substance on which the effect of this product is based is Benazepril. It is a potent antihypertensive medication that is also produced by other companies but sold under other names. People who cannot afford the therapy with the branded medication or simply do not overpay for the brand when they buy Lotensin can choose to get a generic version of the medication, i.e. the same drug but with another trade name. It’s easy to find this version of the medication. For instance, you can get it right from this web page.
The formulation is used for:
- Secondary hypertension;
- Heart failure.
The effect of the formulation is due to the suppression of angiotensin-converting enzyme and blocking of the transition of angiotensin I to II form of hormone, a powerful vasoconstrictor, i.e. the blood-vessels-narrowing agent. It also increases plasma renin activity and aldosterone secretion by the adrenal glands, reduces total peripheral vascular resistance, and increases the concentration of local vasodilators.
After the use of the medication orally, around 37% of the dosage are active in the body. The medication is metabolized in the liver with the achievement of the highest concentration in the blood in a half an hour to an hour. The effect of the formulation is developed within an hour of intake; the peak is reached in two-four hours and maintained within a day.
Contraindications for Lotensin use
People with the below-listed conditions are not advised to buy generic Lotensin as they are prone to developing severe adverse reactions from the medication use:
- Allergy to the main or auxiliary components of the pills;
- History of angioedema (swelling);
- Systemic lupus erythematosus;
- Systemic scleroderma;
- Bone marrow hypoplasia;
- Cerebrovascular insufficiency;
- Renal artery stenosis;
- Single kidney or renal transplant;
- Abnormal liver and kidney functions.
If a patient has any other chronic or acute conditions not listed here, he or she should inform their doctors before they start the therapy with the formulation so that they would be able to adjust the dosages accordingly.
- Arterial hypertension with Lotensin is treated with the initial dosage of 10 mg a day. The dosage can be raised to 20 mg a day. It can be adjusted based on the dynamics of the arterial pressure with an interval of one to two weeks. The higher dosages can be split into two intakes. The highest daily dosage is 40 mg in one or two intakes.
If the monotherapy with the medication doesn’t provide the sufficient effect, additionally other antihypertensive medication can be appointed, for instance, a thiazide diuretic or calcium antagonist. But the dosage of the medications must be lower than usual.
If before you buy Benazepril and start using it you have been taking a diuretic, two-three days before the therapy start the use of the diuretic should be discontinued and resumed only if necessary when the course is already started and if only Benazepril is insufficient. If it is impossible to discontinue the use of a diuretic, the initial dosage of Lotensin or its analog should be lowered to 5 mg a day instead of 10 mg to avoid a sharp drop of arterial pressure.
- Chronic heart failure is treated with an initial dosage of 2.5 mg once a day. To prevent the negative effects of a sharp drop of arterial pressure, patients who use the medication for the first time should be under a doctor’s supervision.
If no desired effect is achieved and if a patient doesn’t develop any negative effects from the medication use, the dosage can be raised to 5 mg once a day. Depending on the effectiveness, in two to four weeks of the course, the dosage can be raised to 10 mg or even 20 mg with gradual increases over time.
Lotensin dosage adjustments
- Individuals with kidney failure and cc over 30 ml per minute do not require dosage adjustments.
- Individuals with cc lower than 30 ml per minute should start the therapy with 5 mg a day. The dosage can be raised to 10 mg a day which is the maximum dosage for this group of patients. For additional effect, if needed, non-thiazide diuretics or other antihypertensive medications should be appointed.
There are no data on the actual overdoses of the medication but the possible symptoms that can develop include a sharp drop of arterial tension and deterioration of blood supply to vital organs.
If an overdose is noticed shortly after the dosage is taken, vomiting and gastric lavage should be initiated. Then, symptomatic treatment is performed.
Lotensin adverse effects
The medication is usually well-tolerated and very rarely causes any negative effects. Nevertheless, the package insert contains the following list of adverse reactions:
- Palpitations, orthostatic hypotension, chest pain, angina, arrhythmia, myocardial infarction;
- Symptoms of dyspepsia, diarrhea, constipation, nausea, vomiting, abdominal pain, pancreatitis;
- Rash, flushing, itching, photosensitivity, Stevens-Johnson syndrome;
- Hepatitis (mainly cholestatic), cholestatic jaundice;
- Frequent urination, increased levels of urea nitrogen and serum creatinine, impaired renal function;
- Cough, which can lead to irritation of the pharynx and larynx and hoarseness;
- Headache, dizziness, fatigue; drowsiness, insomnia, irritability, paresthesia;
- Hemolytic anemia, thrombocytopenia;
- Tinnitus, a violation of taste;
- Angioedema, swelling of the lips and/or face;
- Arthralgia, arthritis, myalgia.
- In combined use of the medication with diuretics, if dehydration occurs, the blood tension lowering below the norm can occur.
- The formulation should not be combined with potassium-saving diuretics and any other formulations or supplements that increase potassium content. However, if such combinations are prescribed by a doctor, a control over potassium concentration in the blood should be made regularly.
- When the medication is combined with Lithium, the elevation of the latter’s concentration in the blood is observed.
- The effect of the medication can be lowered by the simultaneous use of Indomethacin.
If you undergo a therapy with any medication when you plan to buy generic Benazepril, consult your healthcare provider before you start the therapy.
Where can you buy Lotensin?
You can get the formulation from your local drugstores if you have Rx or order Lotensin generic from our pharmacy to save on the pills and Rx.
We will ship Lotensin to any corner of the world as we specialize in the international delivery of all medications that we sell. The standard shipping can take up to 25 days while express will be only from 5 to 14 days.
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
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