Generic Medication guide:
What is Lotrel and when is it prescribed?
Lotrel is a branded medication made by Novartis, an international pharmaceutical company with the headquarters in Switzerland. The formulation is based on two antihypertensive substances
Amlodipine and Benazepril Hydrochloride. They have the same effect, i.e. lower the arterial tension to the target levels, but through different mechanisms.
The same medication can be bought cheaper if you opt for generic Lotrel, i.e. the same medication made by another manufacturer and sold under another name.
You can buy Lotrel or a generic of the formulation for:
- Chronic stable angina;
- Vasospastic angina (Prinzmetal angina);
- Congestive heart failure.
In the Blood pressure medications section of our online drugstore, you can find various medications used for the same purposes. Only a professional can select you the optimal treatment taking into account all of your peculiarities so you should consult your healthcare provider first before you buy generic Lotrel even if you can do so without Rx from our med store.
The formulation use is prohibited in the following conditions:
- Increased sensitivity to its components or dihydropyridine;
- History of angioedema;
- Systemic lupus erythematosus;
- Systemic scleroderma;
- Bone marrow hypoplasia;
- Cerebrovascular insufficiency;
- Renal artery stenosis;
- Single kidney or renal transplant;
- Violated liver and/or kidney functions;
- Severe arterial hypotension;
- Cardiogenic shock;
- Obstruction of the excretory tract of the left ventricle;
- Hemodynamically unstable heart failure after acute myocardial infarction.
How does Lotrel act?
The effects of the medication are due to the synergic action of two of its main ingredients, calcium channel blocker Amlodipine, and an angiotensin-converting enzyme inhibitor Benazepril.
Amlodipine blocks the entry of calcium ions into the myocardium and into smooth muscles. This effect contributes to the decrease of the arterial tension. The angina management effect is due to the widening of peripheral arterioles and, thus, reduction of peripheral resistance (afterload of the heart). Since the heart rate remains stable, the diminished load on the heart leads to a decrease in energy expenditure and myocardial oxygen demand.
The effect of Benazepril is due to the blocking of angiotensin-converting enzyme and thus the prevention of angiotensin I transformation into angiotensin II, the hormone that causes severe narrowing of the blood vessels. It also increases plasma renin activity and aldosterone secretion by the adrenal glands. Benazepril diminishes total peripheral vascular resistance and promotes the production of local vasodilators.
First of all, you should know that this combined formulation should be used if single-agent-based formulations failed to provide sufficient blood tension lowering.
The dosages should be preferably chosen by a doctor. Thus, even though you can buy Amlodipine + Benazepril Hydrochloride without getting Rx from your doctor, it is better to still consult a specialist to get precise instructions on how to use it namely in your case.
The official instruction provides that the initial dosage is one capsule of Lotrel a day that is equivalent to 2.5 mg Amlodipine and 10 mg of Benazepril.
The efficiency of the chosen dosage can be assessed in two weeks of uninterrupted use. If it is insufficient, the dosage can be gradually raised to four capsules a day or 10 mg Amlodipine and 40 mg of Benazepril. The rise of the dosage should be made once a week or two weeks. If in the use of the highest dosage a stable hypotensive effect isn’t achieved, a new medication should be considered.
Individuals with kidneys dysfunction with creatinine clearance higher than 30 ml per minute do not require dosage adjustments while in lower cc the formulation use is contraindicated.
There have been rare cases of overdose of the medication so there are no statistics on the frequency of related adverse effects development. However, it can be presumed that a drop of blood pressure and slow heartbeat can develop. The treatment requires symptomatic measures performed at a hospital.
Lotrel adverse effects
When you buy generic Amlodipine + Benazepril Hydrochloride, you should know that this combined medication doesn’t have any additional negative effects except for the possible adverse effects caused by its main agents separately. They include:
- Dry cough;
- Plaque on the tongue; tonsils and throat;
- Chest pain;
- Symptoms of hyperkalemia (arrhythmias, tremor of the extremities and lips, increased irritability, difficulty breathing);
- Exacerbation of pancreatitis;
- Dyspeptic phenomena;
- Allergic reactions (skin rashes, joint pain, and angioedema);
- Hot flashes;
- Abdominal pain;
Before you order Lotrel, check with your doctor that you use only acceptable medications that will be compatible with this formulation and in the compatible dosages.
The formulation can be safely combined with thiazide diuretics, alpha-blockers, beta-blockers, prolonged-action nitrates, nitroglycerin, nonsteroidal anti-inflammatory medications, antibiotics, oral hypoglycemic medications but the dosages of the blood-tension-lowering medications should be lowered.
The effect of the formulation is enhanced by diuretics, alcohol, and other antihypertensive medications.
The effect is lowered by the use estrogens and sympathomimetics.
Any medications or supplements that contribute to potassium level elevation such as potassium-saving diuretics raise the risk of hyperkalemia.
The formulation enhances the toxic effect of Lithium salts.
The formulation must be cautiously used in individuals with heart failure as it can promote the swelling of the lungs and cardiovascular complications. Use the medication only if your cardiologist approves.
Individuals with liver function impairment can use the formulation but it is advised to start the course with the minimum dosage and exert caution when raising the dosage.
Where can you buy Lotrel?
In the majority of countries, the medication is sold with Rx only. But online drugstores like ours have our own doctors and pharmacists who can give you the prescription for this medication based on a medical questionnaire. Thus, we offer you to save both on Rx and the pills and order generic Lotrel from our pharmacy instead of the branded medication.
We specialize in the international selling of medications and will ship Lotrel to the U.S., UK EU, and all other countries where international mail is available. The shipping takes from 7 to 25 days. If you need the medication sooner, opt for express shipping. If you have your pills for a month, save maximally ordering for $170 or more and get free standard shipping.
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section