Generic Medication guide:
What is the medication sold under the trademark Zebeta?
Zebeta is a trademark of the world-operating Israeli pharmaceutical company Teva Pharmaceutical Industries. The substance that ensures the medication’s effect is called Bisoprolol. It is also made by other companies and sold under other names.
The formulation has a strong arterial tension-lowering, antiarrhythmic, and antianginal action. The effects of the medication are based on the blocking beta1-adrenoreceptors of the heart, reduction of the catecholamine-stimulated formation of cAMP from ATP, lowering of the intracellular current of calcium ions. It decreases the heart rate, inhibits conductivity, and reduces myocardial contractility.
The antianginal action is due to the lowering in myocardial oxygen need as a result of a normalized heart rate and a reduction of contractility, a prolongation of diastole, and an improvement in myocardial perfusion.
The antiarrhythmic effect is determined by the inhibitory effect on arrhythmogenic factors. The formulation inhibits impulse conduction in antegrade and, to a lesser extent, in retrograde directions through the AV node and along with additional paths.
The tension-lowering effect is also due to a decrease in the activity of the renin-angiotensin system (it does not directly correlate with changes in plasma renin activity).
In therapeutic doses, the formulation does not have a cardiodepressive effect, does not affect glucose metabolism, and does not cause the retention of sodium ions in the body.
The maximum effect develops 1-3 hours after ingestion and lasts for 24 hours.
Your doctor can tell you to buy Zebeta for the management of:
- Arterial hypertension;
- Heart failure with systolic dysfunction of the left ventricle in combination with ACE inhibitors, diuretics, and, if necessary, cardiac glycosides.
Contraindications for Zebeta use
- Acute heart failure or heart failure in a state of decompensation, which requires inotropic therapy
- Cardiogenic shock
- II and III degree block (except for such in patients with an artificial pacemaker)
- Sick sinus syndrome
- Sinoatrial blockade
- Low blood tension
- Uncontrollable bronchial asthma
- Late stages of impaired peripheral circulation or Raynaud's disease
- Metabolic acidosis
- Intolerance of Bisoprolol or other components of the formulation
- Pregnancy and lactation
If you are unsure whether you have any of the listed conditions, make sure to buy generic Zebeta only after consulting your physician or a cardiologist.
Adverse reactions Zebeta can cause
- Bradycardia, signs of heart failure aggravation, AV conduction disorder.
- Dizziness, headache, hearing loss.
- On the part of the organs of sight: decreased tearing (harmful when wearing contact lenses), conjunctivitis.
- Bronchospasm in bronchial asthma or obstructive airway diseases in history, allergic rhinitis.
- Nausea, vomiting, hepatitis, diarrhea, constipation.
- Itching, redness, rash, alopecia. When treating ß-blockers, there may be an aggravation of the condition of patients with psoriasis in the form of a psoriatic rash.
- Muscle weakness, convulsions.
- Feeling cold or numb in the limbs, arterial hypotension (in chronic heart failure), orthostatic hypotension (in chronic heart failure), arterial hypotension (in arterial hypertension or ischemic heart disease).
- Depression, sleep disturbance, nightmares, hallucinations.
- Elevated levels of triglycerides in the blood, increased activity of liver enzymes in the blood plasma.
In the event of side effects or adverse reactions, you must immediately inform the doctor.
Interactions of Zebeta with other substances
- It is incompatible with MAO inhibitors (except MAO-B inhibitors) and with alcohol (possibly excessive reduction in blood pressure, up to orthostatic collapse).
- The formulation potentiates the action of other medications that lower the blood tension. For instance, methyldopa, diuretics, calcium channel blockers, and so on. Thus, their combined use is indicated only if a doctor prescribes and controls the dosages.
- Clonidine, digitalis or guanfacine combined with the medication provide a more dramatic slowdown of the heart rate. Clonidine, digitalis, and also guanfacine can, in addition, inhibit the conduction of impulses.
- In combined treatment with clonidine, it can be canceled only if a few days before the reception of Bisoprolol was completed. Otherwise, an excessive rise in blood tension is possible.
- The combined use of the formulation with certain calcium channel blockers such as verapamil and diltiazem or other antiarrhythmic formulations elevates the risk of AV block. These medicines can be combined only under doctoral supervision since a sharp drop in arterial tension, slowing of the heart rate, and heart failure are possible.
- The combination of the formulation with ergotamine derivatives (for example, ergotamine-containing means for migraine) may lead to disorders of the peripheral blood supply.
- Zebeta enhances the effect of insulin or oral antidiabetic formulations. Signs of hypoglycemia (in particular, rapid pulse) may be masked or mitigated. Thus, such combinations require regular control over blood glucose.
- Since the functional state of the heart may deteriorate due to anesthesia, before performing surgery, the performing anesthesia physician should be informed about the therapy with this medication.
- The medication increases plasma lidocaine concentration; Sulfasalazine elevates the level of Zebeta in plasma.
- The simultaneous use of the medication and sympathomimetic agents (for example, contained in cough medications, nose drops and, eye drops), the effect of Zebeta may be lowered.
- The blood tension-lowering effect is weakened by NSAIDs, estrogens, xanthines.
- When the medication is combined with rifampicin, the half-life of bisoprolol may be slightly reduced. Increasing the dose is usually not required.
- Joint reception with grapefruit and carambola, which slow down the metabolism of bisoprolol and increase its concentration in the blood, is undesirable.
Zebeta dosage regimen
The medication is taken in the morning regardless of meal intake. Here you can find the official dosage recommendations but it’s better to consult your doctor before you buy Bisoprolol.
- High arterial tension and ischemic heart disease are treated with the initial usage of minimal dosage of 5 mg with the subsequent dosage raise. In a light increase of arterial tension, the dosage can be 2.5 mg a day. If needed, the dosage can be raised to 10 mg a day. The higher dosages are rarely used and only if a doctor appoints. The maximally prescribed dosage is 20 mg a day.
- Chronic heart failure with systolic dysfunction of the left ventricle is treated by the use of the formulation along with ACE inhibitors, diuretics, and, if necessary, cardiac glycosides. The therapy with the medication must be initiated in individuals without the signs of the disease exacerbation. The therapy is started with the lowest dosage, 1.25 mg a day. If the therapy is well tolerated, the dosage is raised to 2.5 mg during the next week, and so on until the achievement of 10 mg a day. But please note that only a doctor can choose the dosage for you and the correct rate of dosage raise in your case. If the maximum dosage is poorly tolerated, the lowering of the dosage is made. If during the dosage increase the aggravation of the condition is observed, arterial hypotension or bradycardia is developed, a temporary dosage lowering or even a temporary medication use discontinuation can be needed but the withdrawal must not be abrupt. Besides, after the condition stabilization, repeated use of the therapy should be considered.
Individuals with mild liver or kidney dysfunction do not need dosage adjustments. For individuals with severe liver or kidney failure, the highest daily dosage is 10 mg.
In case of overdose, atrioventricular block, bradycardia, drop of arterial tension, and dizziness were recorded. The treatment requires supporting symptomatic therapy at a hospital.
Precautions when using Zebeta
When you buy Bisoprolol, you should know that the use of the medication mustn’t be abruptly discontinued as it can cause a temporary sharp aggravation of the condition treated.
The formulation should be cautiously used in:
- Conditions accompanied by bronchospasms.
- Diabetes with fluctuations of blood glucose;
- Individuals who follow a strict diet;
- When doing allergy tests as the medication can enhance the sensitivity to allergens and cause aggravated allergic reactions.
- Atrioventricular block of I degree;
- Prinzmetal angina pectoris;
- Obliterating diseases of the peripheral arteries (at the beginning of therapy may increase complaints);
- If general anesthesia is planned.
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
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