Generic Medication guide:
What is the medication called Casodex?
Casodex is a brand of AstraZeneca pharmaceutical company but the active substance called Bicalutamide is also produced and marketed by other companies. It means that if your doctor prescribes you Casodex, you can instead buy generic Casodex, a cheaper medication with the same composition and effect.
Bicalutamide is a nonsteroidal antiandrogenic agent that binds to androgen receptors without activating gene expression, thus blocking androgenic stimulation. This leads to regression of prostate tumors.
The use of the medication in the dosage of 150 mg a day for men with locally prevalent cancer of the prostate as a hormonal therapy along the main treatment or adjuvant therapy (after the main treatment) significantly reduces the risk of disease advancement and bone metastases. It is also proven that the medication improves survival prognosis and prevention from relapses of the disease.
The indications for the formulation use are:
- 50 mg dosage is prescribed in combination with (gonadotropin-releasing hormone) or surgical removal of the tumor for the therapy of advanced prostate cancer.
- 150 mg dosage is prescribed for the monotherapy or additional therapy along with surgery and radiation therapy in with locally advanced prostate cancer; as monotherapy of locally advanced prostate cancer in the inability to perform other treatment methods (such as surgery).
Contraindications for Casodex use
The use of the formulation is prohibited for:
- Women and children;
- Increased sensitivity to the components of the medication manifested in severe adverse effects;
- Simultaneous use with terfenadine, astemizole, and cisapride.
The medication can be used but cautiously in impaired liver function.
How is Casodex used?
Before you buy Casodex, your doctor must prescribe it to you so that you would be sure that the medication is suitable for you.
The general instruction prescribes a single pill use a day at the same time every day at least for two years.
Men with kidney dysfunction do not need dosage adjustments.
Men with mild liver dysfunction do not need dosage adjustments. In moderate to severe liver dysfunction, an increased accumulation of the active agent in the body can occur.
There are no data on the overdose of the medication. If it occurs and any symptoms occur, symptomatic therapy is performed. If you took an increased dosage, you can induce vomiting within the first two hours after the overdose to minimize the likelihood of adverse effects.
Casodex adverse reactions
- From the circulatory and lymphatic systems: anemia.
- Allergy, angioedema, urticaria.
- Cardiovascular system: hot flashes, prolongation of the QT interval.
- On the part of the digestive tract: abdominal pain, nausea, constipation, bloating, and indigestion.
- On the part of the digestive system: hepatotoxicity, jaundice, increased transaminase b, hepatic impairment (lethal effects were reported).
- Lightheadedness, drowsiness.
- Mental disorders: low sex drive, depression.
- On the part of the respiratory system: interstitial lung disease (reported lethal consequences).
- Alopecia, hirsutism/hair regrowth, rash, dry skin, itching, photosensitivity reactions.
- On the part of the kidneys and urinary system: hematuria.
- Gynecomastia, breast tenderness e, erectile dysfunction.
- Loss of appetite, weight gain.
- General disorders: asthenia, edema, chest pain.
Interactions of Casodex with other substances
- It is prohibited to use the medication along with terfenadine, astemizole, cisapride and cyclosporine.
- The medication should be cautiously used together with calcium channel blockers. Possible dosage adjustment may be needed in the occurrence of adverse effects.
- The level of the medication in the blood can be increased if it is taken along with ketoconazole or cimetidine as these medications can inhibit Bicalutamide’s metabolism.
- Bicalutamide is able to release the anticoagulant coumarin row warfarin with its combination with proteins. It is necessary to carefully control the prothrombin time in the appointment of the medication patients who are treated with coumarin.
- The medication in an inhibitor of CYP3A4 so it can interfere with the metabolism of medications that need this enzyme for the effect rendering.
- Casodex and its generics should be cautiously used along with medications that can extend QT interval or induce tachycardia. These medications include antiarrhythmic agents, for example, quinidine, disopyramide, and class III, for example, amiodarone, sotalol, dofetilide, ibutilide, methadone, moxifloxacin, and antipsychotics.
Precautions when using Casodex
- If you have liver function impairment, before you buy Bicalutamide, you should know that it is highly preferable to monitor liver function during the therapy especially during the first half of a year of the medication use to catch any negative changes early. If severe dysfunction occurs, the treatment with the medication must be discontinued.
- In patients who use the medication who still suffer from the progression of the disease, the therapy must be reconsidered.
- In patients who receive coumarin anticoagulants, prothrombin time must be regularly checked.
- As the medication influences CYP3A4 enzyme, the medications metabolized with its participation should be cautiously combined with Casodex.
- Patients with lactose intolerance need to be informed that each tablet with a dose of 50 mg of the active substance contains 61 mg of lactose monohydrate, and with a dose of 150 mg 183 mg.
- The medication must not be used by women and children.
- The formulation doesn’t influence the ability to focus yet it is possible to develop allergic reactions so it is advised to refrain from driving or engaging in any potentially dangerous activities within the first days of Bicalutamide use.
You can buy generic Bicalutamide without a prescription at 4RXStore to save your money on the therapy. Nevertheless, we highly encourage you to get the medication and use it only after consulting a specialist and getting the whole treatment plan customized for your condition.
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
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