Generic Medication guide:
What is Hydrea?
Hydrea is a brand name owned by the American pharmaceutical company Bristol-Myers Squibb. The active substance of the medication is called Hydroxyurea and is also available under other names and at cheaper prices in a form of generic.
Hydroxyurea is an anti-tumor medication, a cytostatic (drugs that disrupt the growth, development and division mechanisms of all body cells, including malignant, thereby initiating their programmed death). It specifically inhibits DNA synthesis enzymes in the fast-dividing cells.
The medication’s effect is objectively assessed within six weeks of the capsules use. The effect is manifested in the reduction of the tumor size and the stopping of the tumor growth.
Hydroxyurea significantly increases the effectiveness of radiation therapy for brain tumors and cervical cancer.
The medication can be also used for the treatment of psoriasis (mainly pustular form), Sneddon-Wilkinson's disease, gangrenous pyodermatosis, psoriatic erythroderma, and sickle cell anemia.
You can buy Hydrea or its analogs if your doctor prescribes it to you for:
- Chronic myeloid leukemia,
- Essential thrombocythemia,
- Malignant tumors of the head and neck (with the exception of lip cancer) with the impossibility of radical surgical treatment or radiation therapy;
- Cervical cancer (in combination with radiation therapy).
The use of Hydrea is contraindicated in:
- Hypersensitivity to the medication;
- Thrombocytopenia (less than 100 • 109 / l);
- Severe leukopenia (less than 2.5 • 109 / l);
- Pregnancy, breastfeeding.
The use is possible but with caution and assessment of the risks and benefits in:
- Renal and/or liver failure;
- Anemia (must be eliminated before starting treatment);
- Viral (including chickenpox, shingles), fungal and bacterial infections.
Adverse effects Hydrea use can cause
When you buy generic Hydrea, you should know that besides the positive effects it can also cause certain negative reactions and symptoms:
- Hematopoietic system: inhibition of bone marrow function (leukopenia, anemia, and occasionally thrombocytopenia).
- Gastrointestinal: stomatitis, anorexia, nausea, vomiting, diarrhea, and constipation.
- Dermatology: maculosis-papular rash, facial erythema, and peripheral erythema. In some cases, alopecia is noted. In some cases, as a result of daily use of the formulation for several years, patients had hyperpigmentation, erythema, atrophy of the skin and nails, peeling, purple papules, and skin toxic vasculitis, including vasculitis ulceration and gangrene. In rare cases, alopecia and skin cancer have been reported.
- Nervous system: the use of large doses of the medication can lead to moderate drowsiness. Neurological disorders were noted in individual cases and were limited to headache, dizziness, disorientation, hallucinations, and seizures.
- Kidneys: the formulation may occasionally cause temporary impaired renal function, accompanied by an increase in serum uric acid, blood urea nitrogen (ACS) and creatinine. In some cases, dysuria can develop.
- Other effects: Fever, chills, malaise and increased ESR (erythrocyte sedimentation rate) have also been reported. In some cases, acute pulmonary reactions have been described, including diffuse infiltration of the lungs, fever, and shortness of breath associated with the use of the formulation.
Hydrea dosage and use recommendations
Here you can find the recommendations on the dosages excerpt from the official instruction but please note that when you buy Hydroxyurea you should use it only as your doctor prescribed based on the type and stage of the disease, your weight, age, and many other individual factors.
The medication is taken by mouth with a sufficient amount of water.
- Solid tumors are treated with interval therapy in the dosage of 80 mg per kilogram of the body weight once a day every third day. Continuous therapy is made with a dosage of 20–30 mg per kilogram of body weight per day, once per day for three weeks. Interval therapy is preferable as it lowers the toxic effect of the medication on the brain.
- Carcinomas of the head, neck and cervix are treated with 80 mg per kilogram of body weight once a day, every third day in combination with radiation therapy. The treatment with the medication is started not less than seven days before the start of the radiation therapy and must be continued throughout the whole radiotherapy course. After radiation therapy, the drug is continued to be taken for an unlimited time with constant monitoring of the patient and in the absence of unusual or severe manifestations of the drug's influence.
- Resistant chronic myelocytic leukemia: continuous therapy at a dose of 20 to 30 mg per kilogram of body weight daily once a day is appointed.
Evaluation of the effectiveness of the formulation is carried out after 6 weeks of treatment. In clinical remission, treatment may continue indefinitely. Treatment should be interrupted if the content of leukocytes becomes less than 2500 in 1 cubic mm or platelets - less than 100 000 in 1 cubic mm 3. After 3 days, the blood test is repeated. Treatment is resumed when the content of leukocytes and red blood cells begins to grow markedly.
The use of high dosages of the medication (over 60 mg per kilogram of weight) the negative effects are enhanced and a serious dysfunction of bone marrow can occur.
The treatment requires symptomatic measures, prophylactic anti-infective therapy, and transfusion of blood components according to indications.
When you buy Hydroxyurea, you should know that it can interact with other medications:
- In case of a combination of the medication with other bone marrow suppressing medications or radiotherapy, the negative effect on the bone marrow is potentiated.
- There is a likelihood that the medication use can increase the level of blood uric acid, an adjustment of the uricosuric drugs (drugs that increase the excretion of uric acid from the body) can be required.
- In individuals with HIV when the medication is combined with didanosine and Stavudine severe pancreatitis, liver damage, and peripheral neuropathy can develop.
Precautions and special recommendations
- When you buy generic Hydroxyurea you should know that the treatment should be made under strict medical supervision.
- The medication must be cautiously used in senior patients, kids, individuals who underwent radiotherapy and chemotherapy, in kidney tumor, with renal and hepatic failure. Before treatment, correction of deep anemia (transfusion of whole blood products) is indicated. Before and during treatment (at least once a week) a regular blood test is necessary; with a decrease in the number of leukocytes and platelets below the set norms, the treatment is interrupted until a clear tendency towards normalization of hematological parameters appears. Dynamic monitoring of uric acid, creatinine, and transaminase levels is also recommended; with a decrease in creatinine less than 10 ml/min, the dose is two-fold lowered.
- It is recommended to do all dental procedures before the start of the therapy or postpone until normalization of the blood picture (there is a risk of microbial infections, slowing of the healing process, and bleeding gums). Throughout the therapy, caution should be exerted when using toothbrushes, floss or toothpicks.
- During the therapy, it is advised to refrain from vaccination and contacts with people who got vaccinated, are suffering from viral or bacterial infections. The use of live vaccines in individuals with remission of leucosis is allowed at least three months after the last chemotherapy course.
- Any signs of bone marrow suppression, including unusual bleeding, bruising, black stool, blood in urine or feces, or red spots on the skin require an immediate visit to a doctor.
- During the therapy, it is advised to minimize the risk of cuts and traumas due to potential severe bleeding.
- When using Hydroxyurea, it is important to drink enough water and urinate frequently for the ensure uric acid excretion.
- When undergoing a combination therapy, it is important to observe the set timing for every drug intake.
- If there is no objective improvement of the condition due to the use of the formulation within six weeks, the use of Hydroxyurea should be stopped. If the effect is observed, the use of the medication can be continued indefinitely.
- Individuals with developed leukopenia must be carefully observed to identify signs of infection, and, if necessary, antibiotics should be prescribed. Patients with neutropenia with increasing body temperature are given broad-spectrum antibiotics.
- In patients with thrombocytopenia that has developed as a result of the use the medication, it is recommended to observe special precautions (limiting the frequency of venipuncture, discontinuation of intramuscular injections, inspection of sites for intravenous dosing, skin and mucous membranes, no use acetylsalicylic acid, etc. ).
- During the therapy it is recommended to refrain from driving vehicles or perform any work that requires high attention focus.
- The combination of the medication use with radiotherapy can enhance the likelihood of such adverse reactions as bone marrow aplasia, dyspepsia and development of ulcerative lesions of the gastrointestinal tract.
- During the therapy, it is encouraged to use reliable contraception methods.
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
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