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4RX Store > Medication List > Cholesterol drugs > Order Lopid online

Cholesterol Medication (Lopid)

 
Generic name:
Lopid
Brand name:
Gemfibrozil
Description:
Lopid is one of the brands under which the medicinal formulation Gemfibrozil is sold. The medication lowers the level of “bad” cholesterol through the prevention of its formation and facilitation of its washing out of the body. Besides, it increases the level of “good” cholesterol which is needed for body cells repair. The use of the medication substantially lowers the risk of cardiovascular diseases and death due to a heart disease. The medication is appointed for hyperlipoproteinemia and secondary hyperlipoproteinemia caused by diseases that are difficult to treat (diabetes, gout, hypothyroidism). Find out more useful information below.
Indications:
Primary hyperlipoproteinemia, Secondary hyperlipoproteinemia
Benefits:
The medication helps to lower total and “bad” cholesterol and raise “good” cholesterol. It’s use prevents heart diseases
Manufacture:
Pfizer
Pfizer
Synonyms:
Bolutol, Cholespid, Decrelip, Fibratol, Fibrocit, Genlip, Hipolixan, Jezil
 
   
Lopid (Generic Gemfibrozil)
 
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  Generic Medication guide:

What is Lopid and when is it appointed?

Lopid is a brand name owned by the American pharmaceutical giant Pfizer. The active agent of the medication is called Gemfibrozil. It is also manufactured by other pharmaceutical companies but sold under other names. The benefit of buying the medication under a different name is that the less advertised it is, the fewer money costs a pill.

Gemfibrozil is a hypocholesterolemic and hypolipidemic formulation that normalizes the lipid composition of blood plasma. It reduces the content of triglycerides, including very-low-density lipoproteins, and increases high-density cholesterol (“good” cholesterol needed for the body to repair its damages), apolipoprotein AI and apolipoprotein AII.

The effect of the medication is due to the inhibition of peripheral lipolysis, promotion of elimination of free fatty acids from the liver and blocking of the inclusion of long-chain acyls in newly synthesized triglycerides (thereby reducing their synthesis in the liver). It also accelerates the circulation (removal) of cholesterol from the liver and stimulates its excretion with feces.

When taken orally, the substance is well absorbed when taken orally. It is mainly excreted by the kidneys as metabolites.

Short drug info
Trade names Lopid, Jezil, others
Pregnancy category US: C (Risk not ruled out)
Routes of administration By mouth
Legal status In general: Rx (Prescription only)
Bioavailability Close to 100%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Elimination half-life 1.5 hours
Excretion Renal 94% Feces 6%

The studies of the medication show that it drops the level of the total cholesterol by 40-45%, low-density lipoproteins by 40-60% while causing the raise in the “good” cholesterol. These results were observed in patients with heterozygous familial hypercholesterolemia, non-familial forms of hypercholesterolemia and mixed hyperlipidemia, including patients with non-insulin-dependent diabetes mellitus. As a result of the described changes, the risk of cardiovascular diseases and death related to them drops substantially.

Property Name
Property Value
Molecular Weight 250.33 g/mol
XLogP3-AA 3.8
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 6
Heavy Atom Count 18
Complexity 273
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Compound Is Canonicalized yes

Indications for Lopid use include:

- Hyperlipoproteinemia (IIb, IV and V types), not corrected by a special diet and exercise, in the presence of other risk factors;

- Secondary hyperlipoproteinemia caused by diseases that are difficult to treat (diabetes, gout, hypothyroidism).

In simpler words, you can buy Lopid or its generic version if you have a metabolic disorder that causes a high level of cholesterol. The drug must not be used to lower cholesterol if its high levels are not predetermined by severe conditions or inherited disorders.

Prohibitions of Lopid use

The medication use is contraindicated in the following cases:

- Hypersensitivity to the medication’s components;

-Primary biliary cirrhosis;

- Pregnancy and lactation period.

The use is possible but with caution in:

- Hypertriglyceridemia,

- Any degree of liver dysfunction;

- Cholelithiasis (bile stasis),

- Chronic cholecystitis.

If you are not sure whether you have any of these conditions or not, consult your doctor first before you buy generic Lopid.

Dosages of Lopid and its generic versions

The general instructions for Gemfibrozil use say that the pills should be taken half an hour before meals without chewing. The single dosage is 600 mg and it is taken twice a day – one dose is taken before breakfast and another one before dinner. Alternatively, 900 mg can be taken once a day before dinner.

The highest admissible daily dosage is 1500 mg. The treatment course is several months. If needed, it can be repeated.

Gemfibrozil adverse effects

- Nervous system disorders: dizziness, headache, excessive fatigue, fainting, paresthesia, drowsiness, depression.

- On the part of the digestive system: dry mouth, decreased appetite, heartburn, nausea, vomiting, gastralgia, abdominal pain, flatulence, diarrhea or constipation, hyperbilirubinemia, increased activity of "liver" transaminases and alkaline phosphatase, cholelithiasis.

- On the part of the musculoskeletal system: myasthenia, myalgia, arthralgia, rhabdomyolysis. From the side of blood-forming organs: leukopenia, anemia, bone marrow hypoplasia.

- On the part of the genitourinary system: reduced potency and/or libido. Allergic reactions: skin rash, dermatitis.

- Other: hypokalemia, alopecia, blurred vision, synovitis.

Lopid interactions

Before you buy Gemfibrozil, you should know that the formulation can negatively interact with some medicines:

- The formulation is incompatible with Lovastatin as severe kidney failure and heart problems can develop.

- The drug reduces the effects of ursodeoxycholic and chenodeoxycholic acids due to an increase in cholesterol excretion in bile.

- Gemfibrozil potentiates the effects of indirect anticoagulants and oral hypoglycemic drugs (sulfonylurea derivatives).

- The use of Gemfibrozil with oral contraceptives increases the risk of lipids metabolism.

If you take any other drugs or supplements not listed here, you should still inform about them your healthcare provider to receive a qualitative and personalized consultation on the medicines combination and precautions.

Precautions for Gemfibrozil use

- During the use of the medication, a regular control over the lipids in the blood is needed. In the lack of effect after three months of the medication use, therapy discontinuation is required.

- During the therapy with Gemfibrozil and after the therapy, a special diet with low fats is required.

- In the long-term treatment, the systematic monitoring of the peripheral blood pattern and liver function indicators are required. In case of a significant deviation of the functional liver samples from the norm, treatment is suspended until their normalization.

- In case a dose is missed, it should be taken as soon as remembered but the dosage must not be doubled. So if it’s already time for the next intake, take a single dosage.

- In the development of muscle pains, you should inform your doctor and get checked for myositis (inflammation of one or more skeletal muscles). In case it is diagnosed, the treatment with the medication must be discontinued.

- In the occurrence of cholelithiasis (stones in the gallbladder), the use of Gemfibrozil must be discontinued.

- During the use of Gemfibrozil, women of fertile age must use reliable contraception but not oral contraceptives as they can negatively interact with the drug. It is preferable to use barrier contraception (condoms). In case pregnancy occurs, you must immediately inform your doctor and discontinue the use of Gemfibrozil.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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