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4RX Store > Medication List > Cholesterol drugs > Order Mevacor online

Cholesterol Medication (Mevacor)

 
Generic name:
Mevacor
Brand name:
Lovastatin
Description:
Mevacor is one of the trade names of the substance Lovastatin. This substance is used to lower the total level of cholesterol, and I particular “bad” cholesterol when diet and exercising aren’t enough. The medication is also prescribed for people with inherited or acquired lipids metabolism dysfunction called hypercholesterolemia and as a prophylaxis of atherosclerosis. To know how to use the drug, what to avoid, and when to stop using it, read our full guide below.
Indications:
Primary hypercholesterolemia with a high content of low-density lipoproteins, Combined hypercholesterolemia with hypertriglyceridemia, Atherosclerosis
Benefits:
The medication helps to drop “bad” cholesterol level and prevent cardiovascular diseases in predisposed individuals
Manufacture:
Sun Pharma
Sun Pharma
Synonyms:
Lostatin, Lovacard, Recol, Altocor, Closterol, Colevix, Hipovastin, Lovasterol, Mevastatin, Pravastatin, Rovacor, Sivlor
 
   
Mevacor (Generic Lovastatin)
 
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  Generic Medication guide:

What is the medication known as Mevacor?

Mevacor is a brand of the U.S.-based pharmaceutical giant Merck. The medication is used to lower the total level of cholesterol and the level of harmful cholesterol which blocks vessels and arteries and can contribute to stroke or myocardial infarction.

The effect of Mevacor is achieved because of the action of its active substance named Lovastatin. The substance is used not only by Merck. You can buy Lovastatin at a greatly lower price if you opt for a less known brand. Such versions of the drug are called generics. They are made by the same formula and have an identical effect but their manufacturers don’t advertise the formulations and are able to price them cheaper.

Short drug info
Trade names Mevacor, Altocor, others
Synonyms Monacolin K, Mevinolin
Pregnancy category US: X (Contraindicated)
Routes of administration By mouth
Legal status US: Rx-only
Bioavailability <5%
Protein binding >98%
Metabolism Hepatic (CYP3A and CYP2C8 substrate)
Elimination half-life 2–5 hours
Excretion Feces (83%), urine (10%)

How does Lovastatin act?

Lovastatin is a lipid-lowering drug made from a culture of Aspergillus terrace. It inhibits the initial stages of cholesterol biosynthesis in the liver. When taken orally, Lovastatin as an inactive lactone is hydrolyzed to beta-hydroxy acid (the active form of Lovastatin), which specifically blocks an enzyme that catalyzes the conversion the consumed fats into "bad" cholesterol. This leads to a decrease in blood the concentration of total cholesterol, low-density lipoproteins (LDL), to lesser extent triglycerides and very-low-density lipoproteins (VLDL), and apolipoprotein B. However, it slightly increases the content of high-density anti-atherogenic lipoproteins (HDL).

Property Name
Property Value
Molecular Weight 404.5 g/mol
XLogP3 4.3
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 7
Heavy Atom Count 29
Complexity 666
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Compound Is Canonicalized yes

When is the use of Lovastatin indicated?

The indications for Lovastatin use include:

- Primary hypercholesterolemia with a high content of low-density lipoproteins (type IIa and IIb) in the lack of the effect of diet therapy;

- Combined hypercholesterolemia with hypertriglyceridemia (hyperlipoproteinemia type IB).

- Atherosclerosis (to slow the progression of coronary atherosclerosis in patients with coronary heart disease and hypercholesterolemia).

When is the use of Lovastatin contraindicated?

The use of the formulation is prohibited in:

- Hypersensitivity to the components;

- Kidney dysfunction;

- Severe liver failure and persistent increase in plasma transaminase levels;

- Pregnancy and breastfeeding;

- Childhood.

If you have any liver or kidney dysfunction or suspect that you might be pregnant, consult your doctor first before you buy Mevacor or its generics based on Lovastatin and start using it even if you have the indications for use.

What side effects can Lovastatin cause?

The formulation is generally well tolerated. The adverse effects which occur usually are mild and short-dated. The listed side effects are not all related to the use of Lovastatin but the class of statins in general.

- On the part of the digestive tract: nausea, vomiting, loss of appetite, abdominal pain, constipation, diarrhea, dyspepsia, flatulence, dry mouth, change in taste, acid regurgitation, and pancreatitis.

- On the part of the digestive system: hepatitis, bile stasis and yellowing of the skin, cirrhosis, fatty degeneration of the liver, necrosis of the liver, hepatic failure.

- On the part of the muscles: muscle spasms and pain, arthralgia.

- Nervous system disorders: dizziness, headache, facial nerve paralysis, tremor, paresthesia, and peripheral neuropathy.

- Mental disorders: agitation, anxiety, depression, cognitive disorders (forgetfulness, impaired memory, confusion), and insomnia.

- From the side of the blood and lymphatic system: anemia, thrombocytopenia, and eosinophilia.

- On the part of the skin and subcutaneous tissue: alopecia, itching, rash, depigmentation of the skin, dry skin, dermatomyositis, vasculitis, and thrombocytopenic purpura.

- Hypersensitivity reactions: urticaria, angioedema, toxic epidermal necrolysis, anaphylactic shock, lupus-erythematosus syndrome, arthritis, photosensitization, fever, chills, hot flashes, Stevens-Johnson syndrome.

- Reproductive system: gynecomastia (an increase of mammary glands), decreased sex drive, impotence.

- Changes in laboratory parameters: elevated levels of transaminases, gamma-glutamyl-transpeptidase, bilirubin, a transient elevation in the content of CPK.

- On the part of the organs of vision: irritation of the mucous membrane of the eyes, blurred vision, some patients may experience blurring of the lens, although there is no clear causal connection with taking the drug.

- Others: chest pain, dysfunction of the thyroid gland, asthenia, weakness, shortness of breath.

How is Lovastatin taken?

Before the therapy with Lovastatin is initiated, a patient must start a low-cholesterol diet which must be maintained during the course of mediation use.

In mild cases of hypercholesterolemia, the formulation us appointed to be used once a day in the evening with meals at a dose of 20 mg. The prescribed dose is between 10 mg and 80 mg 1-2 times a day. If the patient needs to reduce the amount of low-density lipoprotein (LDL) by 20%, then treatment should be started with a dose of 20 mg per day.

In the insufficient effectiveness, the dosage can be raised till the daily intake of 40-80 mg in one or two intakes. The dosage raise can be done with an interval of four weeks.

The highest daily dosage is 80 mg either taken with dinner or split in half for breakfast and dinner. During the therapy, it is recommended to check the level of cholesterol regularly to adjust the dosage when needed.

The duration of the therapy depends on the severity and intensity of the disease symptoms. Kids aged from 10 to 17 (girls are given the drug only if they have been having menstruations for at least one year before the therapy) with heterozygous familial hypercholesterolemia are given 20 mg a day. The highest admissible dosage is 40 mg.

Lovastatin interactions

- The formulation enhances the antiocoagulant (blood-clotting prevention effect) of indirect anticoagulants which raises the risk of bleeding.

- Immunosuppressants, Gemfibrozil, nicotinic acid, cyclosporine, and erythromycins taken with Lovastatin increase the risk of rhabdomyolysis (muscle cell destruction) and acute kidney failure.

- Cholestyramine and Colestipol reduce the amount of Lovastatin active within the body (the use of Lovastatin is admissible in four hours after taking these medicines).

- Cyclosporine elevates the blood plasma levels of the formulation’s metabolites.

- Fibrates, nicotinic acid, itraconazole and other antifungal drugs of the azoles group, and erythromycin increase the risk of myopathy development Precautions for Lovastatin use

- During the therapy, the patients should follow a special low-cholesterol diet.

- The medication must be cautiously used by people with a history of liver disease, as well as people suffering from alcoholism. - Before the initiation of the therapy and throughout it if there are indications, a patient must do liver function tests.

- You must inform your healthcare provider about all symptoms that can indicate liver dysfunction such as fatigue, loss of appetite, abdominal pain, yellowing of the skin, and dark urine.

- There is a risk of myopathy (severe muscle disease), kidney failure, and drop of blood pressure while using Lovastatin.

- In the concurrent use of the formulation with certain other medicines, the risk of myopathy significantly raises.

- In case of fever, pain or weakness in the muscles – inform your doctor immediately as it can indicate myopathy. In case myopathy is diagnosed, the therapy must be discontinued. Usually, after this the symptoms disappear.

- The majority of patients who had developed severe muscle dysfunctions during the use of Lovastatin had the predisposing factors such as kidney failure or diabetes.

- The use of Lovastatin must be temporarily stopped in the occurrence of acute infectious diseases, a few days before a surgery, as well as after an injury or post-surgery period.

- Lovastatin must not be used by people with hereditary intolerance to galactose, Lapp lactase deficiency or glucose-galactose malabsorption syndrome.

- The use of Lovastatin is prohibited during pregnancy so fertile women must use reliable contraception and end the therapy immediately if they become pregnant.

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For more answers see the FAQ section

 

 
 
   
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