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4RX Store > Medication List > Cholesterol drugs > Order Zetia online

Cholesterol Medication (Zetia)

Generic name:
Brand name:
Zetia is a brand of a new medication designed to lower the level of cholesterol in the body and respectively prevent or treat heart and vessel diseases caused by high cholesterol. The active agent of the drug is called Ezetimibe. It is a new substance that acts differently than the other cholesterol-lowering drugs it inhibits the formation of cholesterol in the small intestine thus preventing its penetration into the liver. The drug can be bought under different names and at different prices. You can read the full instruction below and get the generic version of the drug on this page.
High cholesterol, Hypercholesterolemia
The medication effectively lowers the level of cholesterol and prevents cardiovascular diseases
Lupin Pharmaceuticals Inc.
Lupin Pharmaceuticals Inc.
Ezentia, Ezze, Zettez, Ezedoc, Vytorin
Zetia (Generic Ezetimibe)
Actual product may differ in
appearance from image shown.

Order Generic Ezetimibe Buy Zetia 10mg


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  30 pills
$41.79 ($42.11)








  60 pills
$69.75 ($75.73)








  90 pills
$103.93 ($120.04)








  120 pills
$137.24 ($160.14)








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  Generic Medication guide:

What is Zetia and when is it used?

The brand Zetia is owned by an American company Schering-Plough. The medication is based on an agent with an unpatented name Ezetimibe. The agent is a new lipid-lowering formulation that selectively suppresses cholesterol and some plant sterols in the intestine dropping the level of “bad” cholesterol.

Short drug info
Trade names Zetia, Ezetrol, others
Pregnancy category AU: C
US: C (Risk not ruled out)
Routes of administration by mouth (tablets)
Legal status
AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only
Bioavailability 35% to 65%
Protein binding >90%
Metabolism Intestinal wall, liver
Elimination half-life 19 h to 30 h
Excretion Renal 11%, faecal 78%

You can buy Zetia to lower cholesterol but you can also look for Ezetimibe made by another company and sold under another name and get the same drug several times cheaper.

The principle of action of this formulation is different from the mechanism of other lipid-reducing medicines such as statins, bile acids, fibrates, and plant sterols.

The formulation acts in the small bowel preventing the suction of cholesterol; it lowers the volume of cholesterol penetrating from the intestine to the liver. This leads to the diminishing of the reserves of cholesterol in the liver and increases its removal from the blood. Ezetimibe does not enhance the excretion of bile acids (unlike drugs that bind with bile acids), does not suppress cholesterol formation in the liver (like statins). In clinical tests that included eighteen individuals with hypercholesterolemia, Ezetimibe reduced cholesterol suction in the bowel by 54% in comparison with placebo.

The indications Ezetimibe use are:

- Primary hypercholesterolemia: the medication is prescribed along with statins as a supplementary therapy to the diet for individuals with primary hypercholesterolemia if only statin therapy is not enough.

- Monotherapy as an addition to the diet to the individuals with primary hypercholesterolemia, for which the use of a statin is impractical or its intolerance exists.

- Homozygous familial hypercholesterolemia: the medication is prescribed along with statins as a supplementary therapy to the diet. Patients may also receive additional treatment (for example, LDL apheresis).

- Homozygous sitosterolemia (phytosterolemia): the formulation is appointed as an additional therapy to the diet.

If you think that you have the indications for the formulation use but your doctor hadn’t prescribed you Zetia, you can ask him or her whether you can use the drug and then buy generic Zetia without Rx online.

Who must not use the formulation?

- Individuals with intolerance of the formulation;

- Individuals who use a statin medication if they have liver disease or an unexplained persistent increase in liver transaminase levels;

- Individuals with moderate and severe liver failure;

- Individuals who use fibrates or Cyclosporine.

- Pregnant women.

Dosages of Ezetimibe

During the whole therapy with Ezetimibe, a patient must follow a special low-fat diet.

The recommended dosage is 10 mg (one pill) a day regardless of meals.

If the medication is added to the therapy with statins, the dosage of statin remains unchanged in most cases but their recommendations for use must be checked.

If the medication is taken with bile acids, it should be taken 2 hours before or 4 hours after the acids.

Treatment of kids

The treatment is made only under a specialist’s control.

Children aged 10 years and older (puberty: boys - Tanner stage II and above, girls - no less than a year after first menstruation) do not need dose adjustment, but clinical experience with children (aged ten to seventeen years) is limited.

The use of the medication in children younger than ten years is not encouraged as its safety in this category of patients isn’t sufficiently studied.

Dosage adjustments of Zetia (Ezetimibe)

- Senior patients: do not need dosage adjustments;

- Individuals with liver dysfunction: for individuals with mild hepatic insufficiency (5-6 points on the Child-Pugh score), dose adjustment is not required. Treatment with drug the formulation is not advised for individuals with moderate or severe liver failure.

- Individuals with kidney dysfunction: no dosage lowering is needed.

Ezetimibe adverse effects

Adverse reaction
ZETIA 10 mg (%)
n = 2396
Placebo (%)
n = 1159
Upper respiratory tract infection
Pain in limbs

- From the gastrointestinal tract part: stomach pain; diarrhea, bloating, gastroesophageal reflux dyspepsia, nausea, poor appetite.

- General: fatigue, chest pain;

- From the muscles and connective tissue part: arthralgia muscle cramps; pain in the neck;

- From the vascular system: flushes, high arterial pressure;

- Respiratory: sinusitis, coughing.

- From the hematopoietic system and the lymphatic system: thrombocytopenia.

- The nervous system: dizziness, paresthesia.

- Respiratory, thoracic and mediastinal disorders: shortness of breath.

- From the gastrointestinal tract: pancreatitis constipation.

- On the part of the skin and subcutaneous tissue: erythema multiforme.

- On the part of the muscles and connective tissues: myalgia; myopathy/rhabdomyolysis.

- General violations and violations of the conditions of administration: asthenia.

- Immune system disorders: allergy, including rash, anaphylaxis, and swelling.

- On the part of the liver and biliary tract: hepatitis gallstone disease; cholecystitis.

- Mental disorders: depression.

These and other possible adverse effects rarely occur during medication use and moderate. However, if you started suffering from a malaise with the start of the pills intake you should inform your doctor.

Zetia interactions

- The formulation is prohibited to be taken with statins if a patient suffers from liver disease.

- Antacids (anti heartburn medicines) lower the absorption of Zetia but the effect is minimal.

- The effect of the medication on the reduction of cholesterol can be slowed down by the use of Cholestyramine.

- Individuals who take Ezetimibe and Fenofibrate are at risk of developing cholelithiasis (gallbladder stones). If there are signs of the disease, a patient must undergo a checkup and cease the therapy if the diagnosis is confirmed.

- The use of Fenofibrate or Gemfibrozil insignificantly raises the level of Ezetimibe in the body.

- The medication can be safely used by statins but the dosages must be adjusted by a specialist. - The medication can negatively affect the liver when combined with cyclosporine.

Zetia precautions

- If the medication is used along with statin medication, the guide for the statin use must be carefully studied and a dosage adjustment made if needed. During the trials, individuals who received Ezetimibe and statins had the elevation of liver transaminases so a regular control over the liver function is mandatory.

- In clinical tests, the frequency of myopathy or muscles destruction related to the use of the formulation did not exceed that in comparison with the corresponding control group. The danger of toxicity to skeletal muscles increases in the following cases: high doses of a statin, age over 65 years, hypothyroidism, renal dysfunction, and also depends on the specific statin used and the simultaneous use of other formulations. If myopathy or rhabdomyolysis is suspected, treatment with Ezetimibe and statin should be stopped immediately.

If you have any diseases or conditions that are not listed here but your healthcare provider who prescribes you Ezetimibe doesn’t know about, please inform your doctor and follow their recommendations.

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