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4RX Store > Medication List > Diabetes drugs > Order Actos online

Diabetes Medication (Actos)

Generic name:
Brand name:
The medication marketed as Actos is based on Pioglitazone. It is a product that lowers blood sugar and can be used either alone or in combination with metformin, sulfonylurea derivatives, and insulin if their use doesn’t render the expected effect. Pioglitazone also positively affects the level of cholesterol. It can be used only by adults. Read more about the drug below to know how to use it, when not to use it, and what are the risks associated with the use of Pioglitazone.
Monotherapy of diabetes type 2, Combined therapy of diabetes type 2
The medication helps normalizing blood sugar in the insufficient effect of the first-line medications
IPCA - A dose of life
IPCA - A dose of life
Dibizone, Piolgem, Piosys, Actost, Pioglitazona
Actos (Generic Pioglitazone)
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  Generic Medication guide:

What is Actos and when is it used?

Actos is a brand of a medication registered and promoted by the Japanese company Takeda Pharmaceutical. The base of the medication is Pioglitazone. It is a substance that is designed to reduce blood sugar.

Short drug info
Trade names Actos, others
Pregnancy category C (not used)
Routes of administration by mouth (tablets)
Drug class Thiazolidinedione
Legal status UK: POM (Prescription only)
US: Rx-only
Protein binding >99%
Metabolism liver (CYP2C8)
Elimination half-life 3–7 hours
Excretion in bile

The substance Pioglitazone is also made and marketed by other pharmaceutical companies under different names and at different prices. If you want to get the medication cheap, you should look for generic Actos or Pioglitazone online. At this webpage, you can buy generic Actos made by another large drug-making company called Ipca.

The action of the product is based on the selective stimulation of certain receptors. It alters the transcription of insulin-sensitive genes involved in the balance of sugar and fat metabolism in fat tissue, muscle, and liver. As a result, the patient enjoys elevated insulin sensitivity in the liver and peripheral tissues, elevated insulin-dependent glucose consumption, dropped output of glucose from the liver, decreased levels of glucose, insulin and glycated hemoglobin in the bloodstream.

The medication doesn’t stimulate the production of insulin and has the effect only in the preserved insulin-producing pancreatic function. In individuals with impaired lipids metabolism, it also elevates the level of triglycerides and increases high-density cholesterol without changing low-density cholesterol and total cholesterol.

Pioglitazone is prescribed as a second-line or third-line therapy of diabetes type II.

As a monotherapy, it is used in adult individuals with the impossibility to use metformin in inadequate control over the blood sugar by the diet and physical exercising.

As a supplementary therapy the medication is used with:

- Metformin in adults with insufficient control of the blood sugar with the use of a single medication in the maximum tolerated dosage.

- Sulfonylurea derivatives in adults who cannot use metformin use and insufficient control over the blood sugar in the single-drug therapy in the maximum tolerated dosage.

- Metformin and Sulfonylurea derivatives in insufficient control over the blood sugar even in the use of two first-line medications. The medicinal substance is also used with insulin in diabetes type II in individuals with the inability to control over the blood sugar with the use of insulin who cannot use metformin.

Who must not use Pioglitazone?

- Intolerance to the active substance or to any of the components of the drug.

- Insulin-dependent type 1 diabetes.

- Diabetic ketoacidosis.

- Severe abnormal liver function.

- Heart failure.

- Bladder cancer, existing or in history.

- Blood in the urine of unknown etiology.

- Pregnancy and breastfeeding.

Restrictions on the use include:

Edematous syndrome, anemia, age up to 18 years.

Use of Pioglitazone, dosages

After the start of the therapy with the medicine, every three to six months, the effectiveness of the therapy must be assessed. If there is no expected response to the therapy, the course must be discontinued.

With the existence of the possible risks of long-term therapy with the medication, the specialists who prescribe the medication must confirm the safety of the medication use for you based on the tests before you buy Actos.

The medication is used only by adults once a day regardless of meals. The tablet must be taken without chewing and washed down with a glass of water.

The initial dosage is 15 mg or 30 mg once a day. If needed, the dosage can be raised to 45 mg a day.

In the combined treatment with insulin, the dose of the latter is unchanged or, if hypoglycemia develops, is lowered.

Dosage adjustments

- Elderly patients do not need dosage adjustments but the therapy must be started with the low dosage. The dose should be increased gradually.

- Individuals with kidney dysfunction do not need dosage adjustments. Individuals on hemodialysis are not advised to use the medication.

- Individuals with liver dysfunction must not use the medication.

Possible adverse effects

Adverse effect
Upper Respiratory Tract Infection

- Visual impairment, macular edema.

- Infections and invasions: upper respiratory tract infections, sinusitis.

- Allergic reactions, anaphylaxis, angioedema, skin rash.

- Benign and malignant tumors.

- From the musculoskeletal system: bone fractures.

- On the part of the nervous system: hypesthesia, headache, insomnia.

- On the part of the digestive tract: flatulence.

- From the urinary system: hematuria.

- Reproductive system: erectile dysfunction.

- General disorders: fatigue.

- Research results: weight gain, increase in lactic dehydrogenase.

Pioglitazone interactions

- The use of sulfonamides, metformin and insulin potentiate the blood sugar-lowering the effect of the formulation.

- The medication can lower the effect of oral contraceptives. There hadn’t been the studies on the effect of the drug on the hormonal contraceptives but the use of other thiazolidinediones caused a drop of hormonal birth control level in the body by 30% and it can cause to a substantial risk of an unplanned pregnancy. Since Pioglitazone is from a class of thiazolidinediones, this interaction must be taken into account by the women of fertile age. The tests on the medication compatibility with other drugs have been continued so the new information can occur. Thus, if you take any medications or plan to start taking them while using Pioglitazone, consult your doctor first.

Special advises for Pioglitazone use

- The treatment must be combined with the diet and physical exercising and with control of glycosylated hemoglobin.

- The medication must be cautiously appointed for individuals with a predisposition to swelling and a moderate rise in the liver enzymes.

- Hypoglycemia in the combined therapy indicates the need for the lowering of the dosages of sulfonamides or insulin.

- In the yellowing of the skin presumably associated with the drug use, the treatment is discontinued.

- Women with anovulatory cycles in the premenopausal period can develop ovulation due to the medication use and get pregnant so adequate birth control measures must be used.

- The use of the formulation for one year or more can be associated with the elevated risk of bladder cancer. Thus, if you have a history of the disease in your family, you must refrain from the medication use.

- If you have any symptoms of the bladder dysfunction during the therapy with Pioglitazone such as blood in urine, urge to urinate, pain when urinating, pain in the back or lower abdomen – inform your health provider right away.

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Product Reviews:

Dec / 21 / 2016 Jane Goldsmith   USA, Chicago
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