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4RX Store > Medication List > Diabetes drugs > Order Amaryl online

Diabetes Medication (Amaryl)

 
Generic name:
Amaryl
Brand name:
Glimepiride
Description:
Amaryl is a brand used to market a diabetic medication based on the substance named Glimepiride. The medication helps lowering the blood sugar level in diabetes type 2 by improving pancreas cells sensitivity to glucose and promoting release of insulin. The medication also helps normalizing cholesterol level, reduces the aggregation of thrombocytes, and the severity of oxidative stress. The drug can be used by adults only. The range of dosages is from 1 to 4 mg a day. The medication is taken once a day. The initial dosage is 1 mg which can be subsequently gradually raised to 4 mg. find out more useful information on the medication from the whole article.
Indications:
Diabetes type 2, Combined therapy of diabetes type 2 with insulin or metformin
Benefits:
The medication helps lowering blood sugar if the effect of the first-line medications is insufficient
Manufacture:
Aventis Pharma
Aventis Pharma
Synonyms:
Glinda, Glymuran, Endial, Glimepirida
 
   
Amaryl (Generic Glimepiride)
 
Actual product may differ in
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  Generic Medication guide:

What is Amaryl and when is it appointed?

Short drug info
Trade names Amaryl, other
Pregnancy category US: C (Risk not ruled out)
Routes of administration by mouth (tablets)
Legal status US: Rx-only
In general: Rx(Prescription only)
Bioavailability 100%
Protein binding >99.5%
Metabolism Complete Liver (1st stage through CYP2C9)
Elimination half-life 5–8 hours
Excretion Urine (~60%), feces (~40%)

The brand Amaryl is owned by a pharmaceutical producer Sanofi but this is not the only company that makes the drug. The main agent of Amaryl is Glimepiride which is anti-diabetic medication. It is also produced and sold by other drug-making companies just under other trademarks.

Glimepiride is a blood sugar-lowering agent active in oral intake. It is from the group of sulfonylurea and can be used in insulin-independent diabetes.

Primarily, the medication acts by the enhancement of the output of insulin from the cells of the pancreas. As in the case with other medications from the class, the result is caused by the strengthening of the susceptibility of the pancreas cells to the stimulation by glucose. On top of that, the medication also regulates the processes influencing blood sugar which are occurring in other organs and tissues. They include, for instance, the bettering of the susceptibility of body tissues to insulin and the dropping of the utilization of insulin by the liver. Use of blood sugar by muscle and fat is possible with the help of transport proteins. The transportation of sugar into these tissues is limited in speed by the glucose utilization stage. Glimepiride very quickly elevates the number of molecules that transport glucose to muscle and adipose tissue cells, which leads to the promotion of glucose absorption.

Other effects of Glimepiride also include:

- Reduction of aggregation of thrombocytes;

- Promotes the balancing of lipids in the blood and helps to prevent atherosclerosis;

- Reduces the severity of oxidative stress, which is persistent in individuals with type 2 diabetes.

You can buy Amaryl or its generic in:

Insulin-independent diabetes type 2 if the level of blood sugar cannot be sufficiently regulated by the diet, physical exercises, and weight loss.

When is the use of Amaryl prohibited?

- Allergy or intolerance of the active or auxiliary ingredients of the tablets and/or other sulfonylurea derivatives.

- Diabetes type I;

- Ketoacidosis, diabetic coma;

- Severe diseases of the liver;

- Severe kidney dysfunction;

- Rare hereditary conditions such as galactose intolerance, lactase deficiency, etc.;

- Pregnancy and lactation;

- For kids.

The use is possible but with caution in:

- In predisposition to hypoglycemia (low blood sugar);

- In other diseases or with ongoing adjustments in the lifestyle;

- In the insufficiency of glucose-6-phosphate dehydrogenase;

- In impaired absorption function of the digestive tract.

Amaryl dosage

Effective therapy of diabetes depends on the individual’s compliance with the prescribed diet, physical exercising, and constant control over blood and urine glucose levels. Failure of an individual to the diet cannot be compensated by taking pills or insulin. Thus, before you buy Glimepiride, make sure you follow your physician recommendations strictly.

The dosage is contingent on the blood and urine sugar tests.

The initial dose is 1 mg a day. If such a dose allows you to achieve control of the disease, it should not be raised. If the glycemic control is not optimal, the dosage can be raised up to 4 mg a day in stages (at intervals of one to two weeks).

The highest admissible dosage is 6 mg a day.

If you use the highest dosage of metformin but it does not provide sufficient glycemic control, the course Glimepiride therapy may be started.

If the medication is used after metformin, its use must be started with a small dosage, which can then be gradually raised to the highest daily dose if needed. The combined course is possible only under a specialist’s supervision.

If the highest dosage of the medication does not render the expected control over the sugar levels, combined therapy with insulin must be considered.

In this case, Glimepiride is taken at the previously used dosages and insulin is begun to be taken with the smallest dosage, which can then be raised if needed. The combined course is possible only under a specialist’s supervision.

In general, one dose of the medication a day is enough. It is advised to take it just before or with breakfast. Mistakes in the use of the medication, such as skipping the dose, mustn’t be corrected by the subsequent intake of a higher dose. If an individual has a sufficient effect with the use of 1 mg of the medication a day, this means that the disease can be regulated by dieting only.

The improved diabetes control is related to enhanced insulin sensitivity, thus the need for the medication use may drop throughout the course. To prevent blood sugar raise, the dosage should be gradually diminished or therapy should be stopped altogether.

It is possible to replace other anti-diabetic medications with Glimepiride. Throughout such a transition, the power and time the previously used agent is washed out of the body should be taken into consideration. Sometimes, if the antidiabetic medication has a long half-life, it is advised to wait several days before starting the Glimepiride course. This will minimize the danger of hypoglycemic response due to the admixture action of the two substances.

The advised initial dose is 1 mg per day. As noted above, the dose can be gradually increased, taking into account reactions to the formulation.

There are some cases when individuals who use insulin are advised by their doctors to change the therapy for glimepiride. Such a replacement must be never done without your physician order and control.

Amaryl adverse effects

Adverse effect
AMARYL
N=745 %
Placebo
N=294 %
Headache
8.2
7.8
Accidental Injury
5.8
3.4
Flu Syndrome
5.4
4.4
Nausea
5.0
3.4
Dizziness
5.0
2.4

- Blood disorders: thrombocytopenia, hemolytic anemia, pancytopenia, and others;

- The immune system: moderate allergic reactions that can progress to severe forms, accompanied by shortness of breath, a drop in blood pressure; possible cross-allergy with sulfonylureas and sulfonamides.

- Metabolic and alimentary disorders: Rarely hypoglycemia.

- Vision: transient visual violations may develop, especially at the beginning of course, because of the balancing in blood sugar levels.

- Digestive tract: nausea, vomiting, diarrhea, discomfort in the abdomen, pain in the abdomen.

- Liver: elevated liver enzymes, abnormal liver function (for example, cholestasis), hepatitis and liver failure.

- Pruritus, rash, urticaria, and sensitivity to light.

Amaryl interactions

Before you buy Glimepiride, you need to check with your physician that you don’t use any medicines it is incompatible with.

- The use of the formulation along with some other medicines can result in lowering or potentiating of its effects and respectively adverse effects.

- The anti-diabetic medication is transformed in the body into an active agent by the CYP2C9 cytochrome. Thus, the medicines that induce this cytochrome, i.e. potentiate its effect, can affect how Glimepiride acts in the body. These medications include Rifampicin, fluconazole, and others.

- The effect of the medication can be enhanced and the likelihood of adverse effects raised in the concurrent use with phenylbutazone, oxyphenbutazone, insulin and other antidiabetic medicines, and others (see the full list in the package insert).

- The effect of the medication is reduced by the use of female hormones; saluretics, thiazide diuretics, thyroid medications, adrenaline and sympathomimetics, and others.

Amaryl precautions

When you buy generic Glimepiride, be ready to follow certain precautions:

- The medication must be taken just before or with the meal.

- If you eat irregularly and skip meals, the use of the medication can cause a drop of blood sugar below the norm. The manifestations of low blood sugar include headache, a strong feeling of hunger, nausea, vomiting, fatigue, drowsiness, sleep disorders, increased motor activity, aggression, inability to focus, lightheadedness, anxiety, and others. The manifestation of a sharp drop of blood sugar may resemble the clinical picture of a stroke. Fortunately, they can be quickly stopped by the eating of fast carbohydrates. Artificial sweeteners are not effective. But you should keep in mind that the symptoms may reoccur later. Severe or prolonged hypoglycemia, which is only temporarily eliminated by taking the usual amount of sugar, requires treatment, and sometimes hospitalization.

Factors contributing to the development of hypoglycemia include:

- Reluctance or the inability of the individual to cooperate with the doctor;

- Irregular meal intakes or skipping meal intakes or fasting;

- Violation of the diet;

- The discrepancy between exercise and carbs consumption;

- Drinking alcohol, especially when combined with skipping meals;

- Renal failure;

-Severe liver dysfunction;

- An overdose of Glimepiride;

- Certain decompensated diseases of the endocrine system that affect carbs metabolism or the counter-regulation of hypoglycemia (for instance, for some disorders of the thyroid gland and insufficient function of the anterior pituitary or adrenal cortex);

- Simultaneous use of other drugs (see the section "Interactions").

The therapy with the medication requires regular control over the sugar levels in the blood and urine. Besides, it is advised to determine the content of glycated hemoglobin in the blood.

Throughout the course of Glimepiride, the indicators of liver function and hematological parameters (especially the number of leukocytes and platelets) should be regularly monitored.

In stressful situations (for example, with injuries, unplanned surgical interventions, infections, accompanied by fever), a temporary transfer of the patient to insulin may be indicated.

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