Buy online cheap generic drugs from online Reputable Pharmacy, no prescription and free doctor consultation    
 
  Buy Quality RX from Reputable Online 4rx DrugStore  
Prescription for generic drug is reviewed by real doctor. Log In for 4RXStore CustomersHealth NewsBuy Online RX AffiliatesBuy Online RX F.A.Q.Buy Online RX Contact Us
 
  Search Sort by name:  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z Support is Offline
 
 
Generic Drugs Category:  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
Herbals Category:  
 
 
 
 
   
Brand Drugs Category:  
 
 
 
 
 
   
 
 

4RX Store > Medication List > Diabetes drugs > Order Prandin online

Diabetes Medication (Prandin)

 
Generic name:
Prandin
Brand name:
Repaglinide
Description:
Prandin is one of the trademarks under which the medicinal antidiabetic substance Repaglinide is sold. It is a medication that helps lowering blood sugar levels in type 2 diabetes particularly elevated during the meals. The effect is due to the enhancement of production of insulin by the pancreas cells. The medication is not a first-line therapy. It can be added to the first-line therapy with insulin o metformin if their effect is insufficient or used instead of them if for some reason those drugs cannot be used.
Indications:
Single-drug therapy of diabetes type 2, Combination therapy of diabetes type 2
Benefits:
The medication helps managing sugar blood level when the effect of diet, exercise, and first-line medications is insufficient
Manufacture:
Novo Nordisk Pharma
Novo Nordisk Pharma
Synonyms:
Eudepa, Novonorm, Repaglinida
 
   
Prandin (Generic Repaglinide)
 
Actual product may differ in
appearance from image shown.
 
 
 
 

Order Generic Repaglinide Buy Prandin 0.5mg

 

Quantity (max. 2)   Package   Price, USD   You save

 

 

 

 

 

 

 

1
 
  100 pills
 
$44.21 ($45.78)
  $1.58

 

 

 

 

 

 

 

1
 
  150 pills
 
$57.35 ($62.41)
  $5.06

 

 

 

 

 

 

 

Price: $
Buy now
 

 

Order Generic Repaglinide Buy Prandin 1mg

 

Quantity (max. 2)   Package   Price, USD   You save

 

 

 

 

 

 

 

1
 
  50 pills
 
$41.79 ($42.11)
  $0.32

 

 

 

 

 

 

 

1
 
  100 pills
 
$66.26 ($72.57)
  $6.31

 

 

 

 

 

 

 

1
 
  150 pills
 
$97.44 ($113.96)
  $16.52

 

 

 

 

 

 

 

Price: $
Buy now
 

 

Order Generic Repaglinide Buy Prandin 2mg

 

Quantity (max. 2)   Package   Price, USD   You save

 

 

 

 

 

 

 

1
 
  50 pills
 
$45.99 ($47.36)
  $1.37

 

 

 

 

 

 

 

1
 
  100 pills
 
$85.58 ($93.90)
  $8.33

 

 

 

 

 

 

 

1
 
  150 pills
 
$127.89 ($145.47)
  $17.58

 

 

 

 

 

 

 

Price: $
Buy now
 



 
  Generic Medication guide:

What is Prandin and when is it used?

Prandin is a brand name owned and promoted by the inventor of the medicinal substance Repaglinide, Novo Nordisk Pharma. It was developed in 1983 to manage type 2 diabetes. But currently, the same medication is also available under other trademarks when made by other companies since the exclusive patent of the inventor expired. Thus, you can buy Prandin at a significantly lower price if you opt for a generic version available at our drugstore.

Short drug info
Trade names Prandin, other
Pregnancy category
AU: C

US: C (Risk not ruled out)
Routes of administration Oral
Legal status
AU: S4 (Prescription only)

UK: POM (prescription-only)

CA: Rx-only

US: Rx-only
Bioavailability 56% (oral)
Protein binding >98%
Metabolism Hepatic oxidation and glucuronidation (CYP3A4-mediated)
Elimination half-life 1 hour
Excretion Fecal (90%) and renal (8%)

Repaglinide is a fast-acting stimulator of insulin production. It quickly reduces blood sugar, promoting the production of insulin by the pancreas. Thus, its effect is contingent on the number of vital b-cells preserved in the gland.

In individuals with type 2 diabetes, an elevation in blood insulin level is observed within half an hour after pill intake. This diminishes the level of sugar in the blood throughout the entire period of assimilation of food intake.

The level of Repaglinide in the blood drops rapidly; the low level is recorded just within four hours after taking it.

It is advised to take the medication before meals. The pill is regularly taken 15 minutes before meals but it can be also taken just prior to meals or half an hour before a meal.

Indications for use:

- Type 2 diabetes, when a diet, normalization of the body mass and physical activity doesn’t allow achieving satisfactory management of sugar levels in the blood.

- The use of the formulation along with metformin or thiazolidinediones is also prescribed for individuals with type 2 diabetes, in which satisfactory glycemic control cannot be reached by using these drugs separately.

The course should be started as a supplement to diet or physical activity to lower the blood sugar levels elevated due to meals.

When the use of Prandin is prohibited?

Even if an individual has the indications for the medication use, it can be prohibited in the presence of such factors as:

- Sensitivity to the main or any other ingredients of the pills;

- Type 1 diabetes mellitus;

- Diabetic ketoacidosis;

- Severe dysfunction of the liver;

- Joint use with Gemfibrozil.

The use is possible if the doctor approves in:

- Fever; - Alcoholism;

- Chronic renal failure.

It shouldn't be prescribed to kids and adolescents, as well as individuals older than 75 years of age (the harmlessness of the use and efficacy in individuals of these age categories have not been determined).

Prandin dosage

Repaglinide is taken orally before each main meal, with the dose being individually chosen to optimize glycemic control.

Besides the patient's self-control of blood and urine sugar levels, the healthcare provider should from time to time test the level of sugar in the blood of individuals treated in order to detect the lowest effective dosage of the medication.

The level of glycosylated hemoglobin is also an informative indicator for the assessment of an individual's response to treatment. Periodic testing is required to detect an inadequate drop in blood sugar level below the lower acceptable level, as well as to detect the absence of a corresponding drop in blood sugar level after an effective initial treatment period.

The formulation is normally taken 15 minutes before meals, but it may vary: it can be taken just prior or half an hour before a meal. If an individual skipped a meal (or had an additional meal), he/she should skip (or add) a dose of the medication for this day.

Initial dose

The healthcare provider selects the dose of the medication based on the reaction of an individual, determined by the level of sugar in the blood. Individuals who had not received antidiabetic drugs before are recommended to start with a dose of 0.5 mg per meal.

Dose selection begins after one to two weeks (the period is detected by the individual's reaction to treatment).

If the individual had been using other antidiabetic formulation, then the starting dose is 1 mg.

Supportive therapy

The highest single dosage is 4 mg. The highest daily dosage is 16 mg.

Transfer of patients taking other oral antidiabetic drugs

Individuals can be immediately transferred from other antidiabetic medications to the course of Repaglinide. The highest advised dosage for individuals who are transferred to receive Repaglinide is 1 mg before a meal.

Complex therapy

If the level of sugar in the blood is not effectively controlled by taking metformin or Repaglinide, these drugs can be betaken simultaneously. The starting dose of the medication is the same as in single-drug therapy. The dose of each medication should be selected based on changes in blood glucose concentration.

Please consult a specialist before you buy generic Prandin and start using it even though you can find the dosage recommendations on your own.

Adverse effects of Prandin

Most often, the negative effects are associated with fluctuations in blood sugar levels that is, hyperglycemia and hypoglycemia, are found. The frequency of such reactions is based both on the characteristics of the course and on the individual characteristics of the patient: eating habits, doses, level of physical activity, stress, etc.

Adverse effect
PRANDIN
(N=352)
Placebo
(N=108)
Upper Respiratory Infection
16
8
Headache
11
10
Sinusitis
6
2
Arthralgia
6
3
Nausea
5
5
Diarrhea
5
2
Back Pain
5
4
Rhinitis
3
3
Constipation
3
2
Vomiting
3
3
Chest pain
3
1
Bronchitis
2
1
Indigestion
2
2
Urinary tract infection
2
1
Tooth disorder
2
0
Allergy
2
0

- Metabolic disease: after taking Repaglinide, like other sugar-lowering drugs, hypoglycemic reactions can occur. Usually, these are moderate reactions that are easy to stop with carbohydrate intake. In more severe cases, glucose infusion may be necessary. As with any hypoglycemic therapy, the development of these reactions depends on individual factors. According to market research, cases of lowered blood sugar have been noted in individuals receiving complex therapy with metformin or thiazolidinedione.

- Gastrointestinal Disorders: In the studies, gastrointestinal disorders such as bellyache, diarrhea, nausea, vomiting, and constipation were observed. The incidence and severity of these symptoms do not differ from those observed with other oral enhancers of insulin production.

- Diseases of the skin: A hypersensitivity reaction to the drug may manifest as redness, itching, and urticaria. In this case, cross-allergy to sulfonylurea should not be suspected, since these drugs have different chemical structures.

- Visual impairment: Fluctuations in blood sugar levels can lead to temporary visual impairment, especially at the beginning of treatment. Such violations were noted in a small number of cases after the start of treatment with Repaglinide. According to clinical studies, in one such case, treatment was not discontinued.

- Impaired liver function: When treating with Repaglinide, isolated cases of raised activity of liver enzymes were noted. In most cases, it was moderate and short-lived. Only a small number of patients were forced to interrupt drug treatment due to enhanced activity of liver enzymes. In rare cases, severe liver dysfunction has been reported, but it is believed that they were not caused by taking the drug.

- Cardiovascular disorders: Type 2 diabetes is related to an elevated risk of heart diseases. One study revealed a raised risk of acute coronary syndrome individuals treated with Repaglinide compared with metformin or acarbose. However, a causal relationship was not established.

Overdose the medication

Symptoms: a drop of blood sugar (hunger, fatigue general weakness, headache, irritability, anxiety, sluggishness, restless sleep, behavioral changes similar to those observed during alcoholic intoxication, decreased focus of attention, speech and vision impairment, nausea, cold sweat, etc.). The therapy of moderate lowering of blood sugar, without neurological symptoms and loss of consciousness, is the intake of fast carbs (sugar or sweets). In severe form (seizures, passing out, coma) urgent hospitalization is required.

Interactions of Prandin

- Beta-blockers, ACE inhibitors, indirect anticoagulants, NSAIDs, salicylates, MAO inhibitors, sulfonamides, alcohol, steroids, and some other medicines - enhance the effect.

- Calcium channel blockers, diuretics, estrogens, including as part of oral birth control, Phenytoin, thyroid hormones, and some other medicines lower the effect of the medication.

Precautions for Prandin use

- Repaglinide is prescribed in cases of unsatisfactory control of blood sugar levels with the help of diet and physical activity. Repaglinide, like other stimulants of insulin secretion, can lead to hypoglycemia. With combined treatment, the risk of the drop of blood sugar below the norm increases. If a patient who has achieved stabilization of glycemic control using oral sugar-lowering drugs is stressed (fever, trauma, infectious disease or surgical intervention), then he/she may experience violations of this control. In such cases, it may be needed to stop taking Repaglinide and temporarily switch to insulin.

- In many individuals, with an increase in the period of taking oral hypoglycemic drugs, their hypoglycemic effect decreases. This may be due to exacerbation of diabetes or to a diminishing in the body's reaction to the formulation. It should be distinguished from primary insufficiency, in which the patient does not respond to the drug taken for the first time. Before making a diagnosis of secondary insufficiency, it is necessary to try to change the dose, as well as to check the patient compliance with the recommendations on diet and physical activity.

- The selection of doses for weakened and emaciated patients should be carried out especially carefully to prevent the occurrence of hypoglycemia.

Special groups of patients

Liver failure

When taking normal doses, the level of Repaglinide and its metabolites may be higher than in individuals with normal liver function. Thus, during the use caution must be exercised. The intervals during dose selection should be raised in order to fully evaluate the individual's response.

Kidney failure

Although the correlation between the level of Repaglinide and creatinine clearance is weak, the clearance of these substances in the blood of individuals with severe kidney dysfunction is diminished. Since individuals with diabetes complicated by kidney failure, insulin sensitivity is enhanced; care must be taken when choosing a dose of the medication.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
Product Reviews:
   



Write a Review:  

Tell us what you think about this drug and share your opinions with other people. Please make sure your review focuses only on this drug.
All reviews are moderated and will be reviewed within two business days. Inappropriate reviews will not be posted.
If you need additional information about the generic drugs, you can contact our RXShop.md customer service agents.
(A customer representative will get back to you asap).

 
Rating:
*
   
Your Full Name:
*
maximum 80 symbols
 
Your e-mail:
*
4RXStore.com does not buy, rent, or sell email addresses to or from third parties.
 
Country, City:
*
Separate by commas. Example: USA, California
 
Your Review:
*
maximum 1000 symbols
 
Enter text shown below:
*
     
     
    I accept the Terms & Conditions and the Privacy Policy.
     
   
 
 
  Copyright © 2009 – 2020 4RXStore.com All rights reserved. All trademarks and registered trademarks are the property of their respective companies.
 
 
  We accept:
   
  e-check Bitcoins 
 
Contact US | Privacy policy | Refund/Reship policy | Terms of services | Health News | Articles | Most Popular | Drug manufacturers
 
 
Modalert | Cialis | Valtrex | Propecia | Proventil | Yasmin | Zitromax | Finpecia