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4RX Store > Medication List > Gastrointestinal drugs > Order Colospa online

Gastrointestinal Medication (Colospa)

Generic name:
Brand name:
Colospa is a trade name of the medication based on the active substance Mebeverine. The medication relieves spasms of the digestive tract and can be used in adults and children older than ten years for intestinal and biliary colic, irritable bowel syndrome, and other conditions accompanied by spasms. Mebeverine can also be used for pregnant and breastfeeding women if their doctor believes that the benefits are greater than the risks.
Spasm of the digestive tract, Intestinal colic, Biliary colic, Irritable bowel syndrome
The medication effectively relieves spasms and pain in the digestive tract
Abbott - A promise for life
Abbott - A promise for life
Colospa (Generic Mebeverine)
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Order Generic Mebeverine Buy Colospa 135mg


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  30 pills
$41.79 ($42.11)








  60 pills
$70.56 ($78.24)








  90 pills
$105.21 ($119.19)








  120 pills
$139.55 ($157.09)








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  Generic Medication guide:

What is Colospa and when is it used?

Colospa is a brand owned by Abbott Laboratories. The product sold under this name is based on Mebeverine which is a spasmolytic agent also sold under a variety of other commercial names. You can buy Colospa cheaper if you opt for a generic version sold at our online drugstore.

Short drug info
Trade names Colospa, Mebeverine, others
Use during pregnancy Possible if the benefits are greater than the risks
Routes of administration By mouth
Drug class Antispasmodics (spasmolytics)
Legal status
UK: P (Pharmacy medicines)

In general: Rx (Prescription only)
Metabolism Liver

The medication has an antispasmodic effect. It blocks the fast sodium channels of the myocyte’s cell membrane and disrupts the entry of Na + ions into the cell, blocks the entry of Ca2 + ions through slow channels, slows down the process of membrane depolarization and prevents the contraction of muscle fibers. Colospa directly relaxes smooth muscles, mainly the digestive tract. It eliminates spasm and has no significant effect on normal intestinal motility. It does not have an anticholinergic effect.

After oral administration, it is not detected in plasma, because undergoes pre-system hydrolysis in the liver with the creation of 3,4-dimethoxybenzoic acid (veratraic acid) and Mebeverine alcohol. It is excreted mainly in the urine exclusively in the form of metabolites - veratric acid and Mebeverine alcohol (including partially in the form of the corresponding carboxylic acid, partially in the form of demethylated carboxylic acid), and is determined in small quantities in bile.

It is entirely washed out within 24 hours after a single dosage intake. It does not cumulate.

Use of the substance Mebeverine

You can buy generic Colospa to cope with:

- Spasm of the gastrointestinal tract (including due to an organic disease);

- Intestinal (bowel) colic,

- Biliary colic (liver, bile ducts);

- Irritable bowel syndrome (symptomatic therapeutic of pain and cramping and intestinal disorders and discomfort).

In kids over twelve years the medication is used for functional disorders of the digestive tract, accompanied by abdominal pain.

When is the use of Mebeverine prohibited?

You must not use the medication in:

- Intolerance of the medication;

- Paralytic bowel obstruction.

Use during pregnancy and breastfeeding

During pregnancy, it is possible to use the medication if the anticipated effect of therapy exceeds the possible risk to the fetus. When used in therapeutic doses, Mebeverine does not penetrate into breast milk.

Dosage regimen of Mebeverine

The capsule is taken orally twenty minutes before a meal, without chewing, and is washed down with a sufficient amount of water.

Dose for adults and children over 10 years old is 1 capsule two times a day. The duration of the course is chosen by the attending physician.

Adverse reactions

When you buy Mebeverine, keep in mind that its use can cause certain negative effects such as:

Adverse Reaction % of patients (n=359)
Headache 10.9
Bloating 10.3
Nausea 6.4
Abdominal pain 5.8
Diarrhea 3.9
Dizziness 1
Dry mouth 3.9
Dizziness/vertigo 2.8
Constipation 2.5


The symptoms of the overdose include hyperactivity of the central nervous system. Treatment implies the removal of an unabsorbed medication from the digestive tract (gastric lavage, administration of activated carbon), symptomatic and supportive therapy. The specific antidote is unknown.

Special recommendations

- Use with caution in patients with severe hepatic and renal impairment, and/or history of heart block.

- The medication does not have the usual anticholinergic effects, so there is no contraindication for patients with prostatic hyperplasia and glaucoma.

The ability to influence the reaction rate when driving vehicles or other mechanisms

No studies have been conducted; care should be taken when driving vehicles and other mechanisms.

Interactions with other medicines

The medication can negatively interact with other substances so you should consult a specialist or at least read the package insert precautions before taking Mebeverine with any other substances.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section


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