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4RX Store > Medication List > Gastrointestinal drugs > Order Flagyl online

Gastrointestinal Medication (Flagyl)

Generic name:
Brand name:
Flagyl or as it is called internationally, Metronidazole, is a potent antibacterial and anti-parasitic medication used for a variety of conditions. The medication is used to treat susceptible infections such as anaerobic infections, amebiasis, trichomoniasis, non-specific vaginitis. It has a broad range of action meaning that many bacteria and parasites can be eliminated with this drug. Read the complete guide below to find out all important information about Metronidazole.
Protozoal infections, Extraintestinal amebiasis, Intestinal amoebiasis (amoebic dysentery), Trichomoniasis, Balantidiasis, Giardiasis, Cutaneous leishmaniasis, Trichomonas vaginitis, Trichomonas urethritis, Infections of bones and joints, central nervous system infections, Meningitis, Brain abscess, Bacterial endocarditis, Pneumonia, Empyema and lung abscess, Abdominal infections (peritonitis, liver abscess), Pelvic infections, Endometritis, Abscess of the fallopian tubes and ovaries, vaginal infections after surgery, Skin and soft tissue infections
The medication helps to cure susceptible infections quickly, some of them can be treated at home
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Flagyl (Generic Metronidazol)
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  Generic Medication guide:

What is the medication sold under the name Flagyl?

The commercial name Flagyl is used to market a medicinal substance with an unpatented name Metronidazole. The same medication is sold under a variety of names so you can buy Flagyl cheaper if you opt for a less promoted name and get the medication from our online drugstore.

Short drug info
Trade names Flagyl, Metro, others
Pregnancy category
AU: B2

US: B (No risk in non-human studies)
Routes of administration by mouth, topical, rectal, IV, vaginal
Legal status
AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only
Bioavailability 80% (by mouth), 60–80% (rectal), 20–25% (vaginal)
Metabolism Hepatic
Elimination half-life 8 hours
Excretion Urine (77%), feces (14%)

The medication has an antibacterial, antiulcer, and antimicrobial effects.

It penetrates into the respiratory chain of bacteria, which disrupts the respiratory processes and causes cell death. In addition, in some types of anaerobes, it has the ability to inhibit DNA synthesis and cause its degradation.


Absorption: When taken orally, Metronidazole is quickly and almost fully absorbed (at least 80% per hour). The highest level in serum that is achieved after oral intake is similar to that achieved after intravenous infusions of the same doses.

Oral bioavailability is 100% and does not decrease significantly while eating.

Distribution: Approximately 1 hour after a single dose of 500 mg, the average highest plasma level is 10 mcg/ml. After 3 hours, the average plasma concentration is 13.5 g / ml.

The elimination half-life is 8-10 hours, the binding to blood proteins is negligible - no more than 20%.

The distribution is fast and significant, with concentrations close to the levels of the medication in plasma, in the lungs, kidneys, liver, skin, bile, and other body fluids.

The medication penetrates through the placental barrier and is found in breast milk.

The metabolism of the substance occurs by oxidation in the liver. Two metabolites are formed: the main alcohol metabolite, providing approximately 30% of the antibacterial activity of Metronidazole relative to anaerobic bacteria, the half-life is approximately 11 hours; an acid metabolite present in less quantity and provides approximately 5% of the antibacterial activity of the formulation.

Washing out from the body: significant concentration in the liver and bile; low concentration in the colon; minor elimination with feces. Around 35-65% of the medication is eliminated through the kidneys.

Indications for Flagyl use

You can buy generic Flagyl for:

- Infections caused by microorganisms that are susceptible to the formulation. They inclde: amoebiasis; trichomoniasis; non-specific vaginitis; giardiasis; surgical infections induced by anaerobic microorganisms.

- As a substitute for the intravenous treatment of infections caused by anaerobic microorganisms sensitive to Metronidazole.

Contraindications for the medication use

- Hypersensitivity to Metronidazole or to medicines of the imidazole group, as well as to other components of the drug.

- Children’s age up to 6 years (this particular form of the medication).

Dosage and administration

Before you buy Metronidazole to treat any disease, we strongly advise you to get a consultation from a specialist who will also prescribe you the optimal dosage based on your personal features.

375 mg/1
500 mg
Tablet, extended release
750 mg
15 (3.8%)
10 (2.8%)
10 mg/1g

Here you can find general recommendations:

- In case of amoebiasis, the medication is taken continuously for 7 days. Adults: 1.5 g per day, i.e. 500 mg (two pills) thrice a day. Children older than six years: 30-40 mg per kilogram of the body weight per day split into three intakes. In the event of a liver abscess with amoebiasis, drainage or aspiration of pus should be carried out beside the anti-infection therapy.

- Giardiasis treated for 5 days. Adults prescribe 750 mg-1 g of metronidazole per day. Kids aged from six to ten years old are given 375 mg per day, 10-15 years - 500 mg per day.

-Trichomoniasis in women (urethritis and vaginitis due to trichomonads), the course is continued for ten days, combining 250 mg (one pill) taken twice a day and one vaginal suppository (500 mg) per day. Anyone you have sexual relationship with should be treated at the same time, regardless of the signs of Trichomonas infection, even if the result of laboratory tests is negative.

- Trichomoniasis in men (urethritis due to trichomonads), Metronidazole is prescribed for 10 days in the dosage of 250 mg (one pill) taken twice a day. In exceptional cases, it may be necessary to increase the daily dose to 750 mg or 1 g. - For non-specific vaginitis, prescribe 500 mg (two pills) are taken twice a day 2 times a day for 7 days. Anyone you have sexual relationship with should be treated at the same time, regardless of the signs of Trichomonas infection, even if the result of laboratory tests is negative.

- The treatment of anaerobic infections is made in adults with 1-1.5 g (4-6 pills) a day; for children older than six years, 20-30 mg per kilogram of body weight a day split into two doses are used.


A single dose of not more than 12 g was observed during suicidal attempts and accidental overdose.

Symptoms included vomiting, ataxia, and mild disorientation. Treatment: in the case of a significant overdose, symptomatic therapy should be used.

Adverse reactions

- From the digestive tract: minor digestive upsets such as nausea, vomiting, stool disorders, etc.; glossitis with dry mouth, stomatitis, taste impairment, anorexia; pancreas dysfunction, a change in color or a change in the appearance of the tongue (mycosis).

- From the skin and its appendages: flushing, itching of the skin, skin rash sometimes with risen body temperature; urticaria, angioedema, anaphylactic shock; Stevens-Johnson syndrome.

- From the nervous system: headache; lightheadedness; confusion; cramps encephalopathy and cerebellar syndrome (ataxia, dysarthria, impaired gait, nystagmus, tremor), which may be accompanied by changes in MRI and which usually disappear after the discontinuation of the therapy. temporary visual impairment;

- Mental side effects: hallucinations; psychotic reactions with paranoia and/or delirium, suicidal thoughts, depressed mood. - Elevated levels of liver enzymes, hepatitis, sometimes with the appearance of jaundice. Isolated cases of hepatocellular insufficiency have been reported, in which there may be a need for liver transplantation.

- On the part of the hearing organs: hearing impairment; tinnitus.

- Others: the reddish-brown color of urine due to water-soluble pigments that are formed during the metabolism of this medication.

For the complete list of adverse effects, please read the package insert which you will obtain when you buy generic Metronidazole.

Interaction with other substances

Before you order Flagyl, get acquainted with the substance medicines interactions:

Not advised combinations: Alcohol (as a beverage or as part of medicine as an excipient): avoid drinking alcohol and taking drugs that contain alcohol because you can develop hot flashes, erythema, vomiting, tachycardia.

Do not use the formulation with Disulfiram as there is a risk of acute psychotic episodes or confusion that are restorable after discontinuation of the medication.

Do not use the medication with Busulfan as its level in the plasma and the likelihood of negative effects raise substantially when it is used with Metronidazole.

Combinations requiring cautious use: Anticonvulsants that induce enzymes: Lowered plasma levels of Metronidazole due to enhanced hepatic metabolism by an enzyme inducer. Clinical observation is indicated; a dose adjustment of Metronidazole may also be required during and after treatment with the inducer.

- Rifampicin: Decreased plasma concentrations of Metronidazole due to enhanced hepatic metabolism by rifampicin. Clinical observation is indicated; dose regulation of Metronidazole may also be required during and after rifampicin treatment.

- Lithium: An elevation in plasma lithium levels, which can reach toxic levels, with signs of an overdose of lithium. It is required to closely monitor the level of lithium in the plasma, dose adjustment may be required.

- Fluorouracil: A raise in the toxicity of fluorouracil due to a slowdown in its clearance.

- In patients receiving antibacterial therapy, numerous cases of enhanced activity of oral anticoagulants were recorded which can lead to bleeding. Risk factors, in this case, are the severity of the infection or inflammation, the patient’s age, and general health.

Special recommendations

- Hypersensitivity/disorders of the skin. Allergic reactions can occur, including anaphylactic shock, which can be life-threatening. In this case, it is necessary to cancel the course of metronidazole and begin appropriate therapy. If at the start of the therapy an individual develops erythema and a pustular rash with the body temperature raise, acute generalized exanthematous pustulosis should be suspected; in the event of the development of such a reaction, the course must be discontinued.

- Disorders of the nervous system. In the manifestations typical for encephalopathy or cerebellar syndrome, the patient’s treatment should be immediately reviewed, and the use of the medication should be discontinued. It is required to monitor the condition of patients regarding possible signs of encephalopathy or regarding exacerbation of symptoms in individuals with disorders of the central nervous system. In the event of the development of aseptic meningitis during treatment with the medication, repeated administration of metronidazole is not recommended, and in individuals with a serious infectious disease, an assessment of the benefit/risk ratio should be made.

- Disorders of the peripheral nervous system. It is necessary to monitor the condition of patients regarding possible development of peripheral neuropathy. It is crucial to observe individuals who have to receive a long-term therapy or have severe, chronic or progressive peripheral neurological disorders.

- Disorders from the psyche. After receiving the first dose, individuals may experience psychotic reactions that threaten the safety of patients, especially if they have a history of mental disorders. If this happens, you need to cancel metronidazole, inform your healthcare provider about it and immediately begin appropriate therapeutic measures.

- Hematologic effects. In individuals with a history of hematological abnormalities or who receive the medication in high doses and or for a long time, it is required to regularly perform a blood test, especially regarding the content of white blood cells. In patients with leukopenia, the decision on whether to continue course depends on the severity of the infection.

- Pediatric patients. The use of pills of this dosage is prohibited for kids younger than six years of age because of the risk of shortness of breath. For other children, other dosage forms of medicines based on metronidazole is available.

Influence on the results of laboratory tests

Metronidazole can immobilize treponema, thereby causing a false-positive Nelson test result. Patients should be aware of the possible confusion, lightheadedness, hallucinations, and other potentially dangerous adverse effects so they should not drive vehicles or operate any dangerous equipment while undergoing the course.

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Product Reviews:

Jul / 06 / 2018 Rebecca Swan   USA, Emerald hills
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