Generic Medication guide:
What is Motilium and when is it used?
Motilium is one of the trademarks registered for selling the medicinal substance with an unpatented name Domperidone. To buy Motilium cheap, choose a generic version with the same composition from our online pharmacy.
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Short drug info
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Trade names |
Motilium, many others |
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Pregnancy category |
AU: B2
US: N (Not classified yet) |
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Routes of administration |
By mouth |
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Dosage per pill |
10 mg |
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Drug class |
D2 receptor antagonist; Prolactin releaser |
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Legal status |
UK: POM (Prescription only)
In general: prescription-only |
Motilium is an enhancer of bowel movement that also has an anti-nausea effect. It is an antagonist of dopamine. The anti-nausea action is manifested due to combinations of suppression to dopamine receptors located in the trigger region and peripheral action.
The medication raises the duration of duodenal contractions and improves elimination of the stomach’s content. Motilium enhances the tone and pressure of the sphincter in the lower part of the esophagus in healthy patients.
Domperidone does not affect gastric secretion.
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Pharmacokinetics
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Protein binding |
~92% |
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Metabolism |
Hepatic and intestinal |
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Metabolites |
All inactive |
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Elimination half-life |
7.5 hours |
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Excretion |
Feces: 66%
Urine: 32%
Breast milk: small quantities |
When is Motilium used?
You can buy generic Motilium for:
- Dyspeptic symptoms, i.e. bloating, pain in the stomach, burping;
- Nausea, vomiting (including after chemotherapy);
- Gag reflex syndrome in kids.
Dosage and administration
Adults and kids over twelve years of age with a bodyweight of 35 kg or more are prescribed the following dosages:
1. Chronic dyspepsia:
10 mg (1 pill) thrice a day and, if needed, before bedtime. If needed, the specified dosage can be doubled.
2. Severe nausea and vomiting:
20 mg (2 pills) three to four times a day prior to meals and at bedtime.
Tablets are taken 15-30 minutes prior to a meal.
The highest daily dosage is 80 mg.
In kidney failure, it is advised to reduce the frequency of intakes.
The duration of the initial course is one month. Then the patient's condition should be assessed and the need for further treatment considered.
Pregnancy or breastfeeding
You can buy Domperidone and use it during pregnancy only as prescribed by your healthcare provider if he/she believes that the benefit exceeds the risk to the fetus.
While taking the medication you should refrain from breastfeeding, as there is no accurate data on the effect on the baby.
If you are pregnant, consult your healthcare provider before you order generic Motilium and start using it.
Application Features
- Motilium is not advised to be used for motion sickness.
- The formulation must be used with caution in senior individuals or individuals with a history of heart disease or heart disease.
- It must be prescribed with caution to individuals with mild liver and/or kidney dysfunction.
- If there are signs of heart arrhythmia, the use of the medication should be ceased, and the user should right away seek a consultation with a healthcare specialist.
- Antacids or antisecretory formulations should not be taken in combination with Motilium, as they reduce its oral bioavailability. When used together, Domperidone should be taken prior to meals and antacid or antisecretory medicines after meals.
- The pills contain lactose, so the medication cannot be used in individuals with lactose intolerance, galactosemia and glucose/galactose malabsorption.
The following information should be considered regarding the risk of developing cardiovascular complications when taking the drug:
Domperidone may be associated with the risk of severe arrhythmias or sudden cardiac death (in individuals over 60 years of age); The medication should be used at the lowest effective dose.
Contraindications
- Individual intolerance of the medication;
- Digestive tract bleeding;
- Digestive tract perforation or obstruction of mechanical etiology;
- Prolactinoma; - Liver and/or kidney dysfunction.
Possible adverse effects
You should know when you buy Domperidone that it is in general well tolerated if you do not violate the recommendations for use. But such manifestations are possible:
- Amenorrhea;
- Digestive tract disorders;
- Allergic reactions: urticaria, rash;
- Nervousness, irritability, agitation, depression. Interaction with other substances
- It should not be used with antacids, sodium bicarbonate or cimetidine as they reduce the absorption of the medication.
- Motilium minimizes the adverse effects of Levodopa and Bromocriptine without affecting their efficacy.
- The medication can cause slowing down of reaction and other effects from the part of the nervous system so it's advised to refrain from driving or operating machinery when you buy Domperidone and use it.
Overdose
Symptoms: impaired consciousness, seizures, disorientation, and drowsiness. Treatment: as such, there is no antidote, you must consult a doctor, rinse your stomach, take activated charcoal.
Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section
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