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4RX Store > Medication List > Gastrointestinal drugs > Order Nexium online

Gastrointestinal Medication (Nexium)

Generic name:
Brand name:
The medication sold under the brand name Nexium is based on a proton pump inhibitor Esomeprazole. This substance is also available under other names from different manufacturers. The indications for its use include stomach ulcer, gastroesophageal reflux disease (GERD), erosive reflux esophagitis, treatment and prevention of ulcers occurred due to the use of NSAIDs, Zollinger-Ellison syndrome, and as a part of combination therapy of ulcers caused by Helicobacter pylori. Find out how the medication is used for different purposes from our guide.
Stomach and duodenum ulcer, Gastroesophageal reflux disease (GERD), Erosive reflux esophagitis, Treatment and prevention of ulcers occurred due to the use of NSAIDs, Zollinger-Ellison syndrome, Ulcers caused by Helicobacter pylori
The medication effectively treats and prevents stomach ulcers caused by different factors
AstraZeneca Pharmaceuticals
AstraZeneca Pharmaceuticals
Nexpro, Olzole, Raciper, Sompraz, Omeprazole, Prilosec, Zegerid
Nexium (Generic Esomeprazole)
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Order Generic Esomeprazole Buy Nexium 20mg


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Order Generic Esomeprazole Buy Nexium 40mg


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  Generic Medication guide:

What is the medication sold under the name Nexium and when is it used?

Nexium is a brand of Astra Zeneca. The product is based on Esomeprazole, a medicinal substance that is used to lower stomach acid production and is sold under different trademarks. To buy Nexium at a lower price, you can get a generic version from our online drugstore made by world-known generics manufacturers such as Cipla.

Esomeprazole lowers the acidity of the stomach acid. The action of the medication is due to the repression of the proton pump, an enzyme that promotes the release of stomach juice.

After taking a standard dosage, the effect starts to manifest within forty-sixty minutes. After regular use of a single pill for five days, the average peak acid release decreases by 90% when this indicator is determined six-seven hours after using the dosage on the 5th day.

Short drug info
Trade names Nexium, others
Pregnancy category
AU: B3

US: C (Risk not ruled out)
Routes of administration By mouth, IV
Drug class proton pump inhibitor
Legal status
AU: S2 (Pharmacy only)

UK: General sales list (GSL, OTC)


In general: Over-the-counter (OTC)
Bioavailability 50 to 90%
Metabolism Liver (CYP2C19, CYP3A4)
Elimination half-life 1–1.5 hours
Excretion 80% Kidney, 20% Fecal

Therapeutic effects

Course for the elimination of reflux esophagitis with the medication’s dosage of 40 mg was successful in around 70% of users after a month of therapy and in 94% after two months of therapy.

The use of the formulation for one week along with the prescribed antibacterials led to the full elimination of Helicobacter pylori in around 91% of users. After such therapy for one week, there was no need for further use of medicines that suppress stomach juice acidity due to the successful healing of the ulcer and elimination of its manifestations.

In the use of the formulation in individuals with the examination-proven bleeding of ulcer after three days of therapy, the frequency of recurrence of bleeding was significantly lower and amounted to 5.9% in comparison with 10.3% in the placebo group.

The reduced acidity of stomach juice induces the enhanced growth of bacteria in the digestive tract that are normal in the digestive tract. Therapy with the medications from the group may raise the risk of digestive tract infection caused, for example, by Salmonella or Campylobacter and.

Esomeprazole is more effective than ranitidine in treating ulcers in individuals who use NSAIDs. Esomeprazole is effective in the prophylaxis of stomach and duodenal ulcers in individuals who use NSAIDs (in individuals older than 60 years).

Indications for the medication use

You can buy generic Esomeprazole for:

A) Gastroesophageal reflux disease (GERD):

- Therapy of erosive reflux esophagitis;

- Prevention of relapses in cured esophagitis;

- Therapy of GERD.

B) Together with antibacterial agents for eradicating Helicobacter pylori:

- Prevention of reoccurrence of ulcers.

C) Therapy and prophylaxis of ulcers induced by extended use of NSAIDs.

D) Therapy of Zollinger-Ellison syndrome.

Contraindications for the medication use

Do not buy Nexium if you have:

- Intolerance of Esomeprazole, benzimidazole or other components of the medication.

- Use nelfinavir. Application restrictions

- Simultaneous use of Digoxin (in senior individuals), clopidogrel;

- Appearance of new symptoms from the digestive tract or a recent change in existing ones;

- Previous operations on the digestive tract;

- Jaundice, severe liver dysfunction;

- Severe renal failure;

- Pregnancy.

Adverse reactions of Nexium

When you buy generic Nexium, you have to now that you can develop certain adverse effects:

Adverse Reactions % of Esomeprazole users
Headache 10.9
Bloating 10.3
Nausea 6.4
Pain in the abdomen 5.8
Diarrhea 3.9
Dryness of the mouth 3.9
Lightheadedness 2.8
Constipation 2.5

- Blood disorders;

- Allergic reactions such as raised body temperature, allergic swelling and anaphylactic reactions, dermatitis, itching, rash, erythema, and others, hyponatremia, hypomagnesemia;

- Trouble falling asleep, confusion, depression, and others.

- Headache, weakness, paresthesia, sluggishness, taste violation.

- Blurred vision.

- Bronchospasm.

- Stomatitis, digestive tract candidiasis, polyps of the fundus glands, stool disorders, bloating, vomiting, dryness of the mouth, hepatitis, and others.

- Muscle pain and weakness.

There are not all possible adverse effects, for the full list, please refer to the package insert.

Dosage regimen

The Esomeprazole tablet should be taken entirely without crushing with a sufficient amount of liquid.

Adults and kids over twelve years old GERD

- Erosive reflux esophagitis: 40 mg one time per day for a month. If needed, the curse can be extended for another month - Long-term relapse prevention in cured esophagitis: 20 mg once a day.

- GERD without esophagitis: 20 mg once a day. The course is followed for a month and then the assessment is made. If the symptoms remain, an additional medical examination is required. After the fading of the symptoms, the medication can be taken when needed, i.e. if you plan to eat food that commonly causes the symptoms of GERD in your case.

Therapy of ulcer induced by Helicobacter pylori: adults are appointed antibacterials and 20 mg of Nexium a day.

Ulcers due to NSAIDs: the regular dosage for the therapy and prophylaxis is 20 mg once a day. The length of the course is one to two months.

Maintenance of hemostasis and prophylaxis of reoccurred bleeding of the ulcer after the course of the medication: 40 mg once a day for a month.

Zollinger-Ellison syndrome: 40 mg two times a day. The dosage and course duration are selected individually. In most individuals, the disease can be controlled by taking from 80 to 160 mg of Esomeprazole per day. If the dose exceeds 80 mg/day, it should be divided into two doses.

Before you buy generic Esomeprazole, consult your healthcare provider about your diagnosis and preferable dosages.


When starting the therapy, make sure to consult with your healthcare provider whether you can combine this drug with other substances. The medication lowers the stomach acidity which can affect the potency and duration of other medicines effect.


Before you order Nexium, you should know that:

- In any unusual symptoms, for instance, such as substantial unprompted body mass loss, frequent vomiting, vomiting with blood, the development of a cancerous tumor must be excluded because the course with the medication may lead to a smoothing of symptoms and thus delay the establishment of the correct diagnosis. Mandatory specialist consultation is required in the following cases:

- In a history of stomach ulcers or operations on the digestive tract;

- During continuous symptomatic treatment of dyspepsia or heartburn for one month or more;

- With the development of jaundice or severe liver disease;

- For patients older than 55 years with the appearance of new symptoms from the digestive tract or a recent change in existing ones;

- If suspicion of H. pylori.

- Patients with recurring symptoms of dyspepsia/heartburn or receiving Esomeprazole for a long period should be under regular healthcare specialist’s supervision. The use of the medication is not advised for a long time for prophylaxis purposes.

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For more answers see the FAQ section


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