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4RX Store > Medication List > Gastrointestinal drugs > Order Protonix online

Gastrointestinal Medication (Protonix)

Generic name:
Brand name:
Protonix is a medication based on Pantoprazole. It is a proton pump inhibitor that is used to suppress the acidity of the stomach juice to let ulcers heal and prevent ulcers. The indications for the use include also gastroesophageal reflux disease and conditions in which gastric juice is produced in excess such as Zollinger-Ellison syndrome. The medication can be used by adults and children older than 12 years. Read the full guide to know about the dosages, contraindications, adverse effects, and so on.
Reflux esophagitis, Ulcer caused by H. pylori, Duodenal ulcer, Stomach ulcer of different causes, Zollinger-Ellison syndrome, Conditions with enhanced stomach juice production
The medication helps to cure stomach and duodenum ulcers, GERD in just 4-8 weeks
Aristo Pharmaceuticals
Aristo Pharmaceuticals
Lupipan, Pantagon, Pantogen, Pentab, Pantoloc
Protonix (Generic Pantoprazole)
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Order Generic Pantoprazole Buy Protonix 20mg


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  90 pills
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Order Generic Pantoprazole Buy Protonix 40mg


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  Generic Medication guide:

What is the medication sold under the name Protonix?

The medication sold under this name is based on the substance with an international name Pantoprazole. It is a proton pump inhibitor, i.e. the suppressor of a protein that promotes the production of gastric acid.

To buy Protonix at a lower price than usual you can get it from our online drugstore. We sell generics, i.e. the medicines identical to the branded ones but made by other companies.

Short drug info
Trade names Protonix, others
Pregnancy category
AU: B3

US: B (No risk in non-human studies)
Routes of administration by mouth
Legal status In general: Rx (Prescription only)
Drug class proton pump inhibitor
Bioavailability 77%
Metabolism Liver (CYP2C19)
Elimination half-life 1-2 hours
Excretion Urine, Feces

Protonix and the generic versions of the medication lower the acidity of gastric juice and also have antibacterial activity against Helicobacter pylori and can be used to treat stomach ulcers caused by the bacteria. The therapeutic effect after a single dose occurs quickly and lasts for 24 hours.

It provides a rapid reduction in symptoms and healing of duodenal ulcers.

When taken at a dose of 40 mg, the protective effect lasts for more than 19 hours.

After 2 weeks of treatment, complete healing of the duodenal ulcer is observed in 89% of patients. After 4 weeks of treatment, 88% of patients have complete healing of the gastric ulcer. The recurrence rate of peptic ulcer after treatment is 55%.

Within 4 weeks of treatment, it provides complete remission in 82% of patients with gastroesophageal reflux disease (GERD), after 8 weeks - in 92%. Complete endoscopic remission in 57% of children aged 6–13 years with gastroesophageal reflux disease is observed after a month of therapy at a dose of 20 mg/day.

Indications for Protonix use

You can buy generic Protonix for:

- Reflux esophagitis moderate to severe.

- Ulcer caused by H. pylori eradication (used with certain antibiotics).

- Duodenal ulcer.

- Stomach ulcer of a different cause.

- Zollinger-Ellison syndrome and other diseases with enhanced stomach juice production.

When Protonix must not be used?

- Allergy or intolerance of the medicine’s components;

- Hepatitis;

- Liver cirrhosis;

- Therapy with atazanavir.

Application restrictions:

Impaired liver function, childhood (there is no experience with children under 6 years of age).

Pregnancy and breastfeeding

During pregnancy, it is possible to use the medication only under strict indications, when the benefit to the mother outweighs the potential risk to the fetus.

Dosage and administration

Here you can find the general recommendations that you can follow when you buy Pantoprazole online but we highly advise you to get a proper diagnosis and consultation of a specialist first.

- GERD: the dose for children over 12 years of age and adults is one 40 mg pill 1 time per day. In some cases, the dose can be doubled (2 tablets per day), especially in the absence of the effect of the use of other drugs.

- In stomach and duodenal ulcer and with a positive result on Helicobacter pylori, microorganism eradication must be achieved using combination therapy. The medication is taken in the dosage of 40 mg per day along with prescribed antibiotics.

- In stomach or duodenum ulcer without the Helicobacter pylori, the dosage dose is one 40 mg pill 1 time per day. In some cases, the dose can be doubled (2 tablets per day).

- Zollinger-Ellison syndrome and other conditions with enhanced gastric juice production: the initial daily dose is 80 mg (2 tablets). If necessary, after this, the dose can be raised or lowered depending on the indicators of acid secretion. At doses exceeding 80 mg per day, it must be divided into two intakes. A temporary increase in dose over 160 mg is possible, but the duration of use should be limited only by the period necessary for adequate control of acid secretion.

For patients with severely impaired liver function, the dose can be reduced to 1 tablet once every two days. In addition, these patients need to monitor the level of liver enzymes. If their treatment with Pantoprazole is increased, it should be discontinued.

Senior individuals and individuals with impaired renal function are not advised to exceed a daily dose of 40 mg of pantoprazole. An exception is combination therapy, the purpose of which is to eradicate Helicobacter pylori, when elderly patients should receive the usual daily dose of pantoprazole (1 tablet 2 times a day) for 1 week.

Adverse effects

- On the part of the blood: very rarely - leukopenia, thrombocytopenia.

- From the digestive tract: often - pain in the epigastric region, diarrhea, constipation, flatulence; sometimes - nausea, rarely vomiting - dry mouth. General disorders: very rarely - peripheral edema.

- From the liver: very rarely - an elevation in the level of liver enzymes, triglycerides, fever, jaundice or liver failure. On the part of the immune system: very rarely - anaphylactic reactions.

- From the skin: sometimes - allergic reactions (itching, rash) are very rare - urticaria, angioedema, photosensitivity, Lyell syndrome, Stevens-Johnson syndrome.

- From the musculoskeletal system: rarely - arthralgia very rarely - myalgia.

- From the nervous system: often - headache; sometimes - dizziness, visual impairment (blurred) is very rare - depression, hallucinations, disorientation and embarrassment.

- From the urinary system: very rarely - interstitial nephritis.

Adverse reactions in % of patients

Adverse reaction
Abdominal pain


Symptomsof an overdose are unknown. In case of an overdose, diarrhea, vomiting, drowsiness, weakness, dizziness are observed. Indicated gastric lavage, providing the body with sufficient fluid and maintaining water-electrolyte balance.

Interactions with other medicines

Before you buy generic Pantoprazole, make sure to check with your doctor that you don’t take any medicines it is incompatible with:

- Like medicines from the class, the medication is contraindicated to be used with atazanavir.

- Pantoprazole may decrease the absorption of medicines whose bioavailability is pH-dependent (e.g., ketoconazole).

- The medication is metabolized in the liver with the cytochrome P450 enzyme system. Theoretically, it can interact with other medicines that are metabolized through this system such as caffeine, diazepam, diclofenac, ethanol, fenprocoumone, phenytoin, piroxicam, Theophylline, warfarin, and others.

Consult your healthcare provider about the precautions if you take any of such medicines.

Special recommendations

- Pantoprazole is not intended for the treatment of moderate gastrointestinal disorders (dyspepsia).

- In the presence of alarming symptoms (sudden weight loss, vomiting, dysplasia, vomiting with blood, anemia, ground), in the presence of a stomach ulcer, malignant diseases of the esophagus and stomach should be excluded, since treatment can cover the symptoms and delay the establishment of a correct diagnosis.

- The diagnosis of reflux disease should be confirmed endoscopically.

- In senior individuals with poor renal function, it is not advised to exceed a dose of 40 mg /day. In severe liver failure, the dosage regimen must be adjusted - 1 tablet every second day, under the control of the level of liver enzymes (if it increases, the drug should be stopped immediately).

- The drug contains lactose, so individuals with galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section


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