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4RX Store > Medication List > Gastrointestinal drugs > Order Reglan online

Gastrointestinal Medication (Reglan)

 
Generic name:
Reglan
Brand name:
Metoclopramide
Description:
Reglan is one of the brands of the medicinal substance Metoclopramide. The medication has a potent anti-vomiting activity and is used for the nausea and vomiting relief in chemotherapy, radiotherapy, and migraines. It can be used for children. However, Reglan must not be used longer than five days in a row as it can cause extrapyramidal disorders manifested in tremor, muscle stiffness, and others. Read the full guide below to know more about the drug including dosages, adverse effects, precautions, and so on.
Indications:
Nausea due to chemotherapy, Nausea due to radiotherapy, Nausea due to migraines
Benefits:
The medication quickly helps to cope with intense nausea and vomiting caused by certain factors
Manufacture:
IPCA - A dose of life
IPCA - A dose of life
Synonyms:
Cadirdorm, Lynorm, Cerucal, Clopra, Elieten, Gastrese, Gastromax, Imperan, Maxeran, Metaclopramide, Metamide, Metoclol, Parmid, Peraprin, Plasil, Reliveran, Terperan
 
   
Reglan (Generic Metoclopramide)
 
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Order Generic Metoclopramide Buy Reglan 10mg

 

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1
 
  90 pills
 
$41.79 ($42.11)
  $0.32

 

 

 

 

 

 

 

1
 
  120 pills
 
$57.35 ($62.40)
  $5.05

 

 

 

 

 

 

 

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  Generic Medication guide:

What is the medication sold under the name Reglan and when is it used?

Reglan is one of the trademarks registered to market the medicinal substance Metoclopramide. You can buy Reglan cheap if you opt for its generic from our online drugstore. Generic means the same medication simply made and marketed by other pharmaceutical company.

Short drug info
Trade names Primperan, Reglan, others
Pregnancy category
AU: A

US: B (No risk in non-human studies)
Routes of administration By mouth, intravenous, intramuscular
Drug class

D2 receptor antagonist; 5-HT3 receptor antagonist;


5-HT4 receptor agonist; Prolactin releaser

Legal status
AU: S3 (combination with paracetamol), S4 (alone)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only
Bioavailability 80 ± 15% (by mouth)
Metabolism Liver
Elimination half-life 5–6 hours
Excretion
Urine: 70–85%

Feces: 2%

Metoclopramide is a synthetic medication, it is an antagonist of dopamine (D2) receptors, as well as serotonin (5-HT3) receptors (in high doses). The active agent was first synthesized in France and described by Justine-Besancon and Laville in 1964. The mechanism of its action is due to a direct stimulating effect on the release of acetylcholine and stopping the supply of signals between the nerve endings of the stomach and intestines to the brain, in particular to the trigger zone, which is responsible for the activation of the vomiting reflex.

Chemical properties
Property name Property Value
Molecular Weight 299.79 g/mol
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 7
Heavy Atom Count 20
Formal Charge 0
Complexity 300
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Metoclopramide is the medication of choice for stopping vomiting. It is able to eliminate the drug, postoperative, as well as vomiting caused by concomitant diseases. Penetrates through the blood-brain barrier, therefore, the use of toxicosis in pregnant women is ruled out.

The prokinetic effect is used to facilitate clinical examinations of the digestive tract, in particular during enterography. Prokinetics accelerate the promotion of contents in various parts of the digestive tract.

The physiological effects of prokinetics are:

- Increased tone of the lower esophageal sphincter;

- Increased evacuation function of the stomach;

- Enhanced gastroduodenal coordination;

- Enhanced productive intestinal motility;

- Increased contractility of the gallbladder.

The medication is available in the pharmaceutical market in the form of tablets and injection.

Consideration should be given to the development of undesirable effects, in particular, tremors, headache, sluggishness, and heart rhythm disturbances.

You should buy generic Reglan only after consulting a specialist to identify the causes of the development of the disease, discussing possible contraindications for use and the correct selection of the dose of the drug.

Indications for Reglan use

The medication is appointed for adults to prevent nausea and vomiting caused by:

- Radiotherapy;

- Chemotherapy;

- Acute migraine.

Children should be given the medication only as a second-line drug to prevent nausea and vomiting caused by chemotherapy.

When is the use of Reglan prohibited?

You should not buy Metoclopramide and use it in case of:

- Intolerance of the medication components manifested in severe adverse effects, and especially allergy;

- Digestive tract bleeding;

- Mechanical intestinal obstruction;

- Digestive tract perforation;

- Confirmed or suspected pheochromocytoma;

- History of tardive dyskinesia;

- Epilepsy;

- Parkinson's disease;

- Simultaneous use with Levodopa or dopaminergic agonists;

- Established methemoglobinemia;

- Prolactin-dependent tumors.

Application restrictions:

- Bronchial asthma;

- Arterial hypertension;

- Liver and/or kidney failure;

- Old age;

- Children under 14 years of age (for parenteral administration).

Adverse effects of Reglan

When you buy generic Metoclopramide, you should keep in mind that it can cause certain negative effects such as:

- From the gastrointestinal tract: nausea, dry mouth, dyspepsia, constipation, diarrhea.

- From the nervous system: dyskinetic syndrome, mainly in children (involuntary spasmodic movements, in particular in the head, neck and shoulders, spasm of the facial and chewing muscles, spasmodic extension of the legs, and others), headache, dizziness, increased fatigue, sluggishness, tremor, muscle stiffness, seizures, and others. There is a risk of acute (short-term) neurological disorders, which is higher in kids, and tardive dyskinesia in senior individuals. The risk of negative effects on the nervous system enhances with the use of the medication in high doses and long-term therapy.

- From the psyche: asthenia, depression, hallucinations, confusion, anxiety, anxiety, confusion, tinnitus. From the cardiovascular system: bradycardia, atrioventricular block, sinus block, QT interval prolongation, ventricular tachycardia of the Pirouette type, low or high blood tension, shock.

- From the side of the immune system: hypersensitivity reactions, including urticaria, angioedema, anaphylactic reactions.

- On the part of the skin: rash, urticaria, hyperemia, and itching of the skin.

- On the part of the reproductive system and function of the mammary glands: amenorrhea, hyperprolactinemia, galactorrhea, gynecomastia, menstrual irregularities.

- Laboratory indicators: an increase in the level of liver enzymes, an increased level of serum creatine phosphokinase.

Dosages of Reglan

Take orally before meals, without chewing, with plenty of fluids. To minimize adverse reactions probability, the medication should be used only for short-term treatment - no more than five days.

- Adults: the usual therapeutic dosage is 10 mg up to thrice a day. The highest daily dosage is 30 mg.

- Children: the usual dosage is 0.1-0.15 mg/kilogram of the body weight up to three times a day. The highest daily dosage is 0.5 mg per kilogram of the body weight.

Overdose

Symptoms: sleepiness, confusion, irritability, anxiety, convulsions, extrapyramidal disorders; dysfunctions of the cardiovascular system with irregular heartbeat an increase or decrease in blood tension, hallucinations, and others. In the case of the development of extrapyramidal symptoms associated with an overdose, only therapy to lower the symptoms is carried out. Besides, vomiting and intake of activated carbon are undertaken to prevent excessive dosage absorption. Based on the clinical condition, constant monitoring of the heart and respiratory systems are necessary.

Special recommendations

- The drug should not be used to treat chronic diseases or as an additional tool during surgical or radiological procedures.

- When you order Reglan you should know that the most dangerous adverse effects are extrapyramidal disorders, especially in kids and/or when using high doses. These effects are usually observed at the start of therapy and can occur after a single application. In their occurence, for instance, tremor, muscle stiffness, and others, the use of the medication is ceased right away.

- The medication must be taken with an interval of at least six hours to avoid an overdose.

- Long-term treatment use of the medication can lead to tardive dyskinesia, which is potentially irreversible, especially in senior individuals.

- The use with antipsychotics can cause the development of the malignant antipsychotic syndrome. In case of symptoms of a malignant antipsychotic syndrome, the course is immediately discontinued.

- Individuals with CNS disorders and those who take medications affecting the nervous system must be especially cautious and in the occurrence of any negative symptoms discontinue the therapy with Reglan.

- When using Metoclopramide, the symptoms of Parkinson's disease may also intensify.

- Severe adverse reactions from the heart part, including cases of acute vascular insufficiency, prolongation of the QT interval, and others were observed after taking Metoclopramide. Thus, the use of the medication requires special attention in senior individuals, individuals with impaired cardiac conduction, impaired electrolyte balance, and individuals taking medicines that extend the QT interval.

- In impaired renal function or severely impaired liver function, a dose lowering is advised.

- The drug contains lactose, therefore, patients suffering from rare hereditary diseases in which lactose is not tolerated must refrain from the pills use.

Interactions of Reglan

Prohibited combinations:

- Levodopa or dopaminergic agonists.

Combinations to avoid:

- Alcohol enhances the sedative effect of Reglan.

Combinations to pay attention to:

- Inhibitors of the central nervous system (antipsychotics, sedative antihistamine-H1 receptor blockers, and others): potentiate the effect of Reglan.

- Antipsychotics: the combination with Reglan elevates the risk of extrapyramidal disorders.

- Serotonergic drugs used with Reglan may elevate the risk of developing serotonin syndrome.

- Digoxin: The medication can lower the bioavailability of Digoxin. It is necessary to carefully monitor the level of Digoxin in the blood plasma.

- Cyclosporin: Reglan increases the bioavailability of cyclosporin. It is necessary to carefully monitor the level of cyclosporine in blood plasma. The clinical consequences of this phenomenon have not been definitively determined.

- Myvacuria and suxamethonium: injection of metoclopramide may extend the duration of the neuromuscular block. - Metoclopramide may affect the absorption of other substances. So, for example, it can slow down the absorption of cimetidine, accelerate the absorption of paracetamol, various antibiotics (in particular, tetracycline, pivampicillin), lithium. The same time use of Reglan and lithium tablets may cause an increase in plasma lithium levels.

These are not all interactions, for the full list please read the package insert which comes with the pills when you order generic Reglan.

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Our doctor prescribes online for free, and there is no doctor’s consultation fee.

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All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
Product Reviews:
   

 
Nov / 10 / 2016 alex west   USA, Nomandy
  I say thank you to the company, they make it possible to get quality medication for good price. This is the only way out when I cannot afford brand drugs.
   
 


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