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4RX Store > Medication List > Gastrointestinal drugs > Order Zantac online

Gastrointestinal Medication (Zantac)

Generic name:
Brand name:
Zantac is one of the trade names registered to market the medicinal agent Ranitidine. It has an anti-ulcer activity as it suppresses the production of stomach juice due to the inhibition of H2-histamine receptors. The medication is used for the treatment of adults and children older than 12 years for GERD, stomach and duodenum ulcer, prevention of ulcers in the use of nonsteroidal anti-inflammatory drugs, Zollinger-Ellison syndrome, chronic gastritis with hypersecretion of gastric acid, and other conditions in which the suppression of gastric juice production is needed. Read our full guide to know how and when to use the medication, how to combine it with other medicines, and other useful information.
Treatment and prevention of stomach and duodenal ulcer, Treatment and prevention of ulcers due to the use of NSAID, Heartburn, Gastric juice hypersecretion, Symptomatic gastrointestinal ulcers, Erosive esophagitis, Reflux esophagitis, Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, Systemic mastitis, Polymorphism, Chronic dyspepsia, Bleeding from the upper gastrointestinal tract, Prevention of relapse of gastric bleeding in the postoperative period
The medication helps healing stomach and duodenum ulcers effectively as well as prevents their occurrence in predisposing factors
J.B. Chemicals Pharmaceuticals
J.B. Chemicals Pharmaceuticals
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Zantac (Generic Ranitidine)
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  Generic Medication guide:

What is the medication sold under the name Zantac?

Zantac is a brand owned by a pharmaceutical company Sanofi. The effect of the medication is based on the active agent Ranitidine which is an ulcer-healing agent, an antagonist of H2-histamine receptors. It reduces the production of muriatic acid which promotes ulcers healing.

The formulation competitively and reversibly blocks histamine H2 receptors of parietal cells of the gastric mucosa. It suppresses empty stomach and stimulated production of stomach acid, lowers its volume and concentration. The duration of effect after single dosage intake is 12 hours.

You can buy Zantac cheap if you opt for a generic version of the medication, i.e. the same drug made by another manufacturer. You can find a wide range of generics at our online drugstore.

Short drug info
Trade names Zantac, others
Pregnancy category
AU: B1

US: B (No risk in non-human studies)
Routes of administration By mouth, IV
Drug class H2 receptor blocker
Legal status
AU: S2 (Pharmacy only)

UK: General sales list (GSL, OTC)

US: OTC/Rx-only
Bioavailability 50% (by mouth)
Protein binding 15%
Metabolism Liver
Onset of action
55–65 minutes (150 mg dose)

55–115 minutes (75 mg dose)
Elimination half-life 2–3 hours
Excretion 30–70% Kidneys

Indications for Zantac use

- Treatment and prophylaxis of stomach and duodenal ulcer;

- NSAID-induced ulcers treatment;

- Gastric juice hypersecretion;

- Gastroesophageal reflux disease (GERD);

- Zollinger-Ellison syndrome;

- Chronic dyspepsia;

- Bleeding of the digestive tract;

- Prevention of relapse of digestive tract bleeding in the postoperative period.

Contraindications for Zantac use

Do not buy generic Zantac if you have previously used it and suffered from adverse effects or:

- Suffer from cirrhosis of the liver;

- Have severe renal failure;

- Have malignant neoplasms of the stomach;

- Are pregnant or breastfeeding;

- For children under 12 years old.

Application restrictions

- Liver cirrhosis with a history of portosystemic encephalopathy;

- Renal and/or liver failure;

- Acute porphyria (including a history of).

Dosage recommendations

Consult a doctor before you buy Ranitidine. You can follow the general instructions provided below but for the effective and safe therapy, you need a precise diagnosis and treatment course selected by a specialist.

The medication is prescribed for adults and children older than twelve years. It is used regardless of food intake, without chewing, with a small amount of water.

- Peptic ulcer of the stomach and duodenum in the acute phase: 150 mg 2 times a day or 300 mg 1 time per day is used. The duration of this regimen is one month. In case of insufficient effective healing, the same treatment regimen is extended for another month.

- Prevention of the occurrence of ulcers of the stomach and duodenum in the use of NSAIDs: 150 mg used twice a day. The medication is taken for as long as NSAIDs are used.

- Chronic gastritis with high acidity in the acute stage: 150 mg 2 times a day. Treatment course duration is from two weeks to one month.

- Functional dyspepsia: 150 mg are taken twice a day. Treatment course duration is from two weeks to one month.

- Gastroesophageal reflux disease (GERD) to alleviate symptoms: 150 mg is taken 2 times a day. Minimum course duration is two weeks. With prolonged therapy or in the case of exacerbation: 150 mg is taken 2 times a day or 300 mg 1 time per day. The course is continued for two months, if necessary, the course can be extended to a month and a half.

Dosage adjustments

- In renal failure, the daily dose of the drug cannot exceed 150 mg of ranitidine.

- The medication is used for children older than twelve years in the same dosages as for adults.


Symptoms: seizures, irregular heartbeat. Treatment implies vomiting or gastric lavage, and the therapy to minimize the symptoms. In seizures or heart disturbances hospitalization is needed.

Possible adverse effects of Zantac

- Nausea, dry mouth, flatulence, constipation, diarrhea, vomiting, abdominal pain, decreased appetite, acute pancreatitis;

- Hyperemia, itching, rash, dry skin;

- Decreased blood pressure, chest pain, bradycardia, arrhythmia;

- Headache, dizziness, fatigue, confusion, irritability, hallucinations, involuntary movements;

- Leukopenia, thrombocytopenia, bone marrow hypo- and aplasia, immune hemolytic anemia;

- Blurred visual perception, accommodation disorders;

- Arthralgia, myalgia;

- Enlargement of mammary glands, irregular or lacking period, decreased libido, erectile dyfunction.

Even though you can buy Ranitidine without Rx, make sure to inform your healthcare provider about any of the adverse effects you experience while taking the medication as you may need the dosage adjustment, additional checkup or discontinuation of the therapy.

Interactions of generic Zantac

- The medication elevates the level of Metoprolol in serum when taken together.

- In simultaneous administration with antacids, the absorption of Zantac in the digestive tract slows down.

- Due to the increase in the pH of the stomach, while taking the medication, the absorption of itraconazole and ketoconazole may decrease.

- The simultaneous use of generic Zantac with warfarin may change prothrombin time.

- It is possible to increase the excretion time of procainamide and N-acetyl procainamide when it is combined with high doses of Zantac.

- Smoking of tobacco lowers the effectiveness of the medication.

- Do not drink alcohol during the use of the medication.

- When the medication is taken twice a day with triazolam, the level of triazolam in the body doubles.

- The medication reduces the absorption of itraconazole and ketoconazole ( to prevent it, Zantac should be taken two hours after these medicines).

- It inhibits the metabolism of phenazone, hexobarbital, glipizide, buformin, meaning that their effect is extended and potential side effects can occur. Consult your healthcare provider if you take any medications even if they are not listed here if you plan to buy generic Ranitidine and use it.

Chemical properties
Property name Property Value
Molecular Weight 314.41 g/mol
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 9
Heavy Atom Count 21
Formal Charge 0
Complexity 347
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
Special recommendations

- Before starting treatment, it is crucial to exclude cancer of the esophagus, stomach or duodenum because the medication can lower their symptoms and delay the diagnosis.

- The risk of side effects from the part of the heart is elevated in individuals with heart diseases, especially in the use of high doses.

- In long-term treatment of weakened individuals, bacterial infections of the stomach can develop and spread of throughout the body.

- During the use of the medication, a false-positive result is possible in a test for protein in the urine.

- Use with caution in case you suffer from kidneys dysfunction.

- In senior individuals with impaired liver or kidney function, impaired consciousness is possible, which necessitates a dose reduction.

- If the treatment requires the simultaneous use of ranitidine in combination with antacids, then the interval between doses should be at least 1-2 hours.

- Use with caution in acute porphyria and immunodeficiency.

- Ranitidine should be discontinued gradually due to the risk of developing a rebound syndrome in abrupt cancellation.

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