Generic Cialis Medication Guide

Generic Cialis Professional 20 mg is taken to be the newest and strongest medicinal product to increase in potency and treat erectile dysfunction for men. This kind of preparation boasts with the availability to prolong exposure time that usually takes for 36 hours. Thereby, there is no need to keep on indication schedule.

Preparation Formula

1 film-coated pill of Cialis contains:
Tadalafil - 20 mg;
Additional ingredients, including lactose.

Therapeutic Indications

Cialis is taken to treat patients with erection problems.

Method of Application

The preparation is intended for oral administration. Generic Cialis Professional 20 mg is in form of pills, Film-coated, recommended to take as a single piece with water or tea. Cialis is taken without regard to food. Nobody, but doctor specifies the dosing schedule. As a rule, it is recommended to take 1 pill, 15-20 minutes before the expected sexual activity. Considering that fact that preparation effect lasts for 36 hours, the pills can be taken long before. The maximally recommended daily dose of Cialis is 1 pill.

Pharmacokinetics

Preparation absorption

Tadalafil is quick-absorbing preparation. The maximum tadalafil concentration time in plasma is 2 hours after taking medicine in oral. Tadalafil rate of absorption does not depend on the patient’s meal time. Though, Cialis is prescribed to take without regard to food. The medication intake time (morning or evening) causes no influence on preparation absorption rate.

Preparation allocation

The preparation allocation is about 63 l. It means that therapeutic concentration of tadalafil in plasma is 94% to be connected with proteins. The process cannot be influenced by kidney function disorders. More than 0,0005% of daily dose is concentrated in sperm.

Metabolism

Tadalafil is mostly metabolized with the involvement of CYP3A4 isoenzymes. The main circulating metabolites are methyl catechols. This kind of metabolites is less active than tadalafil. Therefore, the concentration of this metabolite has no clinical influence.

Preparation excretion

The healthy patients have 17,5 hours to excrete tadalafil out of their organism. The preparation is excreted out in form of passive metabolites; in general, excrements contain about 61% of daily dose, urine contains about 36% of daily dose.

Sideway Action

Taking Cialis, there is a risk to have a headache and dyspeptic disorders. Besides, it was informed about the isolated cases of back pain, hyperemia of face, nasal obstruction, myalgia, ophthalmalgia, conjunctival hyperemia, giddiness and Quincke’s disease during taking tadalafil. There is also information about the priapism and prolonged erection with taking Cialis. If the patient’s erection lasts for more than 4 hours, ask for medical assistance. The preparation causes the penis tissue damage and loss of a sexual potency.

The side effects are inconspicuous or middling by hazard.

Possible effects - back pain, myalgia, nasal obstruction;

Rare effects - palpebral oedema, ophthalmalgia, conjunctival hyperemia, giddiness;

Very rare effects - allergic reactions, including rashes, nettle rush, Stevens-Johnson syndrome; hypopiesia, syncope; stomach ache and gastro esophageal reflux disease; hyperhidrosis; priapism and erection troubles; blurry vision, occlusion, visual field disorders.

Contraindications

It is not recommended to buy Generic Cialis Professional 20 mg for patients, hypersensitive to tadalafil. It is also contraindicated for patients, taking organic nitrates.
Tadalafil is not prescribed for women and kids that are younger than 18.
It is not recommended to order Generic Cialis Professional 20 mg for patients, suffering from heart diseases, when sexual activity is unacceptable. The preparation contraindications include people with Myocardial infarction or apoplectic fit, cardiac insufficiency, unstable stenocardia, uncontrolled arrhythmia or arterial hypertension.
Be careful to take Cialis preparation, having a risk to develop priapism, including leukaemia, anemia, myelomatosis, chordee, cavernosal fibrosis and Peyronie’s disease.
What is more, it must be preceded with care to prescribe tadalafil preparations for patients, suffering from hepatic disorders and decreased kidney function.

Drug-to-Drug Interaction

It is prohibited to take tadalafil and organic nitrates all together. Tadalafil cannot change the disposition profile of preparations, metabolized with the involvement of cytochrome system ?450.
Combining Cialis and CYP3 A4 inhibitors, there is a risk to increase tadalafil plasma concentration. In particular, tadalafil must be taken carefully together with ritonavir, sacvinavir, erythromycin and itraconasole.
There is a high risk to reduce tadalafil concentration in plasma to use it concomitantly together with rifampicin.
Antacid and enveloping agents reduce the tadalafil availability, indeed.

Special Warnings and Precautions for Use

Aged patients

The healthy aged patients (65 years and more) have a low tadalafil clearance, comparing with 19-45 aged patients. This difference is not considered to be clinical important, so, there is no need to change dosing.
Kidney function disorder
There is no need to change the dose for patients, suffering from kidney function disorder of easy and mild rate. For patients with kidney function disorder of severe rate is not recommended to take Cialis because of tadalafil explosion dose (AUC).

Hepatic diseases

Tadalafil pharmacokinetics for patients with hepatic diseases of easy and mild rate is the same as for healthy patients. The rest of patients with severe rate of hepatic diseases are recommended to check clinically to assess risks and use of preparation.

Pancreatic diabetes

According to research works, there is no need to change tadalafil dose for pancreatic diabetes patients. The difference between healthy and diabetic patients is no more than 19%.

Overdosing

Generic Cialis Professional 20 mg cause such undesired reactions that are analogous to tadalafil side effects to treat therapeutically. There is no specific antidote. To treat overdosing effects, it is recommended to use symptomatic therapy. Hemodialysis cannot make the tadalafil blood concentration lower.

Specific instructions

Sexual activity has potential risk for patients, suffering from heart diseases. Thus, it is not recommended to provide treatment with Cialis and other tadalafil contained preparations for heart disease patients that are not recommended to have sexual activity.

The patients must be informed to seek medical attention immediately if they noticed prolonged erection (more than 4 hours). Incorrect treatment of priapism causes the penis damage. As the result of these actions can be impotence.
Tadalafil is characterized with systematic vasodilator features, causing the low blood pressure. The patients must be examined and prescribed individually to avoid undesired after-effects. It is recommended to ask for immediate help in case of unexpected reactions.

Tadalafil is not considered to be the high risk preparation. Nevertheless, the giddiness symptoms are available. There is a strong necessity to proceed with care by driving car and other potentially dangerous vehicles that need high concentration and fast reactions.

Pediatric Use

Cialis preparations are not taken to use for kids.

Pregnancy and Lactation

Generic Cialis Professional 20 mg is not recommended to use for women.

Dosage Form

Film-coated pills, Generic Cialis Professional 20 mg in blister packs for 1, 2, 4 or 8 dosages.

Storage Conditions

Cialis must be stored no more than 2 years under the temperature from 15 to 30 degrees C.

To conclude, Cialis (tadalafil) relaxes penis muscles. It increases blood supply that is needful to have prolonged erection. The preparation is applied to treat sexual frustration. The preparation is also used as additional component to treat other diseases that are not mentioned in this medical guide. The doctor’s consultation is recommended.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

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