Generic Medication guide:
Generic Flomax optionally and competitively prevents postsynaptic α1-adrenergic receptors placed in smooth muscle of the prostate, bladder neck and prostatic urethra, as well as α1-adrenergic receptors, located primarily bladder’s body. This brings to a mitigation of smooth muscle tone of prostate, bladder neck and prostatic urethra and improves the function of the detrusor. Due to this, decrease signs of obstruction and annoyance bonded with benign prostatic hyperplasia. As a rule, therapeutic impact evolves in 2 weeks after receiving drug, although in some patients a decrease in severity of symptoms noted after the first dose. The ability of this medication is to influence α1-adrenergic receptors is 20 times greater than its capacity to operate with α1-adrenoceptors placed in vascular smooth muscle. Due to this superior selectivity drug does not motive any clinically considerable weaken in systemic blood pressure in patients with hypertension and patients with normal basic blood pressure.
Suction. Generic Flomax is a pill with controlled release based on the matrix using a gel non-ionic type. This dosage form provides a slow release of components and adequate exposure with weak fluctuations in the concentration of drug components in plasma within 24 hours. In the form of tablets Flomax is absorbed in the gut. Absorption is estimated at 57% of the administered dose. The intake of food has no influence on drug’s absorbability. Flomax is described by linear pharmacokinetics.
If you take a pill on an empty stomach, Cmax of tablets in plasma is achieved after an average of 6 hours. Cmax in plasma increases from roughly 6 ng/ml after the first dose to 11 ng/ml at the constant state. The insufficient accumulation in plasma amounts to 40% of the maximum plasma accumulation becomes quicker after meal. There are significant personal various changes among patients in relation to accumulation of drug in plasma after a solitary dose and a reusable dose.
Distribution. The plasma protein connecting is about 99% and VD is small (about 0.2 l/kg).
Metabolism. Flomax is slowly metabolized in liver with the creation of less valid metabolites. Most of the drug is represented in the blood plasma in unchanged form. The ability of medicament to induce the activity of microsomal liver enzymes is virtually absent. When liver refusal is not demanded correction mode.
Excretion. Flomax and its metabolites are primarily excreted in the urine with almost 4-6% of the drug deduced unchanged.
T1/2 tablets in a solitary dose and at the steady condition— 19 and 15 hours respectively.
Indications: benign prostatic hyperplasia (therapy of disorders of urination).
Method of production
You can buy Generic Flomax in the form of:
Tablets: 0.4 mg. controlled release coated 0.4 mg
Instructions for use and dosage regimen
The drug in capsules is administered in a dose of 400 mcg (1 capsule) 1 times a day. Capsules are taken orally after breakfast, squeezed enough water. The capsule is not advised to chew. With a slight and moderate liver function and when damaged renal function dose correction is not demanded.
The drug in tablets is prescribed to take orally at 400 micrograms (1 tablet) 1 time per day regardless of meal time. Duration of use is not limited; the drug is administered as continuous therapy. The tablet should be taken whole, without chewing, to avoid the effect on the extended release of valid substance. In hepatic and renal lack does not demand adjustment of dosing regimen.
Symptoms: decline in blood pressure, compensation tachycardia.
Therapy: symptomatic. BP and HR can restore when taking sick horizontal position. If there is no impact, you can apply tools that expand the BCC and if it is necessary decongestants. It is obliged to check up renal function. It is improbable that dialysis would be productive, because Generic Flomax is intensively limited to proteins of plasma.
To avoid further uptake of the drug should gastric lavage, taking of activated charcoal and osmotic laxatives.
Cardiovascular system: palpitations, orthostatic hypotension.
Digestive system: constipation, diarrhea, nausea, vomiting.
CNS: dizziness; headache; pass out.
Part of the reproductive system: violation of ejaculation; priapism.
Respiratory system: rhinitis.
Allergic reactions: skin rash, itching, urticaria.
The described sealed cases of instability of intraoperative iris symptom during surgery of cataract in patients that multiply the risk of complexities during and after surgery.
Contraindications: hypersensitivity to any component of the product; severe hepatic insufficiency, orthostatic hypotension; chronic renal failure, severe hepatic impairment, hypotension.
Remember that when you order Generic Flomax, it should be taken with caution. During surgery for cataract on the background of the drug may cause unbalance syndrome intraoperative iris syndrome, it is mandatory to be studied by the surgeon for preoperative preparedness of the patient and during the operation.
Before therapy with Flomax, a patient should be considered to eliminate the existence of other diseases that can motive signs as benign prostatic hyperplasia. Before beginning therapy and regularly during treatment should be performed a digital rectal examination and, if required, determining specific prostate antigen.
Patients who have renal failure not required dosage. There is no information about negative impact on capacity to drive cars and occupation potentially hazardous activities do not exist. However, in inclusion with probability of vertigo, to define personal reply of the patient should abstain from activities demanding high focus and speed of psychomotor reactions, involving driving vehicles.
While a simultaneous use of Generic Flomax with cimetidine, it was a minor multiplication in the concentration of Flomax in plasma and furosemide - decreased concentration; however, this does not require changing drug’s dosage. While drug’s usage with diclofenac and warfarin the elimination rate of Flomax may expand. The collaborative use with other alpha1-blockers can guide to a marked reduction in blood pressure.
Keep this drug in the dry place which is protected from light. The temperature should be not above 25 ° C.
Term of storage
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All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
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