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4RX Store > Medication List > Generic Muscle Relaxers drugs

Generic Muscle Relaxers drugs

 
 

Muscle relaxants are medicines that reduce the tone of skeletal muscle with a decrease in motor activity up to complete immobilization. This is required in a number of conditions when muscle spasms prevent individuals from leading a normal life, for instance, ischemic back pain, or diseases of the central nervous system that cause painful chronic spasticity of the muscles, for instance, in multiple sclerosis, injury of the brain and spinal cord.

   
 
     
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At our online drugstore, you can buy different muscle relaxers for different needs without a prescription. However, we highly recommend you to use these medicines only if they are prescribed by your doctor.

What is the mechanism of muscle relaxers action?

The mechanism of action of the medicines from the group is based on the blockade of H-cholinergic receptors in synapses which stops the supply of a nerve impulse to the skeletal muscles, and the muscles stop contracting.

During surgery, intravenous infusions and high dosages are used. The relaxation occurs from the bottom up, from the tips of the toes to the facial muscles. The diaphragm is last to relax. Conductivity recovery occurs in the reverse order. The first subjective sign of the end of muscle relaxation is the patient's attempt to breathe independently. Signs of complete decure: the patient can raise and hold his head for 5 seconds, tightly squeeze his hand and breathe independently for 10-15 minutes without signs of hypoxia. The duration of muscle relaxants lengthens in the presence of such factors: hypotension, hypoxia, hypercapnia, metabolic acidosis, hypovolemia, impaired microcirculation, hypokalemia, deep anesthesia, hypothermia, the elderly patient.

The effect on the M-cholinergic receptors of the heart, smooth muscles and vagus nerve depends on the medication type and administered dosage.

They do not pass through the blood-brain barrier (BBB). Passage through the placental barrier (PB) depends on the medication type and administered dosage. Not soluble in fats. Binding to blood proteins depends on the medication.

Muscle relaxants that can be used at home in a form of tablets are basically the same medicines simply supplied in a different form and in much lower dosages.

General indications for the use of muscle relaxants

The indications for the use of intravenous muscle relaxants at a hospital are:

1. Providing conditions for tracheal intubation.

2. Ensuring muscle relaxation during surgeries to create optimal working conditions for the surgical team without excessive doses of formulations for general anesthesia, as well as the need for muscle relaxation during certain diagnostic procedures performed under general anesthesia (for example, bronchoscopy).

3. Suppression of spontaneous breathing in order to conduct mechanical ventilation.

4. The elimination of convulsive syndrome with the ineffectiveness of anticonvulsants.

5. Blockade of protective reactions to cold in the form of muscle tremors and muscle hypertonicity with artificial hypothermia.

6. Muscle relaxation during reposition of bone fragments and reposition of dislocations in joints where there are powerful muscle masses.

The use of muscle relaxers for the less intense spasticity reduction is prescribed in the following conditions:

- Spasticity in multiple sclerosis;

- Spinal cord tumors, injuries, infections;

- Cerebral strokes;

- Cerebral palsy;

- Inflammation of the membranes of the spinal cord and brain;

- Head injuries;

- Back pain due to muscle spasms in radiculitis, osteochondrosis, or injuries of muscles.

Based on the peculiarities of interaction with receptors, muscle relaxants are divided into two groups:

Depolarizing muscle relaxants
Non-depolarizing muscle relaxants

Ultra short action

Suxamethonium

-
-

Short action

Mivacurium

-

Medium action

Atracurium

Vecuronium

Rocuronium

Cisatracurium

-

Long action

Pipecuronium

Pancuronium

Tubocurarine

- Depolarizing muscle relaxants: when they reach the receptors, these medicines cause persistent depolarization of the synapse membrane, accompanied by a short-term chaotic contraction of muscle fibers (myofasciculation), which passes into muscle relaxation. With persistent depolarization, neuromuscular transmission stops. Muscle relaxation is short-lived, due to the retention of open membrane channels and the impossibility of repolarization. Metabolized by pseudocholinesterase, excreted by the kidneys. There is no antidote.

Indications for the use of depolarizing muscle relaxants:

1. Surgeries and diagnostic manipulations of short action.

2. Intubation as a risk factor and one of the key points at the beginning of the operation.

Possible complications with the use of depolarizing muscle relaxants:

1. Trismus and laryngospasm.

2. Malignant hyperthermia. Most often occurs with trismus in children.

3. Microdamage to muscles. Symptoms: complaints of muscle pain, myoglobinuria.

4. Raise in pressure inside the hollow organs and cavities of the body.

5. The release of potassium into the blood can lead to hyperkalemia, which in turn leads to bradycardia and cardiac arrest.

Contraindications:

1. Patients with initial hyperkalemia (renal failure, extensive burns, and muscle injuries).

2. Patients with heart rhythm disturbance.

3. Patients at risk of complications with increased intracranial pressure, increased pressure in the hollow organs of the gastrointestinal tract. Glaucoma patients.

Formulations:

Currently, due to possible complications, the clinic uses only Suxamethonium, but it is also gradually being replaced by short-acting non-depolarizing muscle relaxants.

- Non-depolarizing muscle relaxants block receptors and membrane channels without opening them, without causing depolarization. The duration of action and properties depend on the drug. You can buy muscle relaxants of this group from our drugstore as they can be used at home in a form of oral tablets.

Formulations: tubocurarine, pipecuronium, atracurium, pancuronium, vecuronium, metocurin, rocuronium, myvacuria, doxacuria.

Antidote: Proserin.

Anticholinesterase medicines block cholinesterase, the amount of acetylcholine increases and it competitively displaces the non-depolarizing muscle relaxant. Prozerin is used in a dose of 0.03-0.05 mg/kg body weight. Atropine 0.1% 0.5 ml is injected 2-3 minutes before use to level the side effects of proserin intravenously. Decuralization is contraindicated in deep muscle block and any violation of the water-electrolyte balance. If the action of proserin ends before the effect of the muscle relaxant, then recurization can occur - the resumption of muscle relaxation due to the activation of cholinesterase and a decrease in the amount of acetylcholine in the synaptic cleft.

- Antispasmodics. Antispasmodics are drugs that relieve spasms of the smooth muscles of internal organs, blood vessels, etc., violating various functions of organs. Antispasmodics are used for various diseases. For example: bronchial asthma, colic - renal, hepatic, etc.

Muscle relaxers you can buy at 4rxstore:

Name
Manufacturer
Indications for use
Cipla
Used to manage the inability to control urination due to the unstable bladder in multiple sclerosis or spina bifida, and in other conditions.
Sun Pharma
Used for multiple sclerosis, spinal cord tumors, spinal cord injuries, spinal cord infections, cerebral strokes, cerebral palsy, inflammation of the membranes of the spinal cord and brain, head injuries.
Sun Pharma
Used for chronic convulsive conditions caused by disorders of the central nervous system, acute muscle cramps of local origin, ischemic back pain.

 

 
 
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