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4RX Store > Medication List > Muscle Relaxers drugs > Order Lioresal online

Muscle Relaxers Medication (Lioresal)

Generic name:
Brand name:
Lioresal is one of the commercial names under which the substance Baclofen is marketed. It is a muscle relaxer that is prescribed I various conditions associated with spastic disorders such as cerebral palsy or in spinal cord tumors, injuries, and so on. The medication is used for the therapy of adults and children. Read our full guide to know how and when to use the drug and what precautions to follow.
Multiple sclerosis, Spinal cord tumors, Spinal cord injuries, Spinal cord infections, Cerebral strokes, Cerebral palsy, Inflammation of the membranes of the spinal cord and brain, Head injuries
The medication helps relieving spasms caused by the dysfunction of the spinal cord
Sun Pharmaceutical Industries Ltd.
Sun Pharmaceutical Industries Ltd.
Riclofen, Kemstro
Lioresal (Generic Baclofen)
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  Generic Medication guide:

What is Lioresal and when is it used?

Lioresal is a brand of the Swiss pharmaceutical company Novartis Pharma. The active substance of the product is Baclofen, a muscle relaxant used for a variety of conditions to relieve spasms. You can find the same medication under other names and buy Lioresal cheaper. For instance, on this webpage, we offer you the same medication made by Sun Pharma, the world-known producer of generics.

Baclofen is a muscle-relaxing substance, working at the level of the spinal cord. From a chemical point of view, Baclofen does not belong to other muscle relaxants.

It lowers the excessive muscle tone caused by damage to the spinal cord. The formulation together and evenly depresses skin reflexes and muscle tone.

Short drug info
Trade names Lioresal, Liofen, Gablofen, others
Routes of administration By mouth, intrathecal
Pregnancy category
AU: B3

US: C (Risk not ruled out)
Legal status
AU: S4 (Prescription only)

US: Rx-only
Bioavailability Well-absorbed
Protein binding 30%
Metabolism 85% excreted in urine/faeces unchanged. 15% metabolised by deamination
Elimination half-life 1.5 to 4 hours
Excretion Urine

The principle of this action most likely consists of hyperpolarization of the ascending nerves and inhibition of both mono- and polysynaptic reflexes at the level of the spinal cord due to stimulation of GABA B receptors. It does not affect the impulses of the nerve endings located in the muscles.

The advantages of using Baclofen are related to its ability to reduce pain flexor cramps and spontaneous muscle contractions, which improves patient mobility and reduces dependence on other people's help, improves rehabilitation.

Indications for use

You can buy generic Lioresal for spastic conditions in:

- Multiple sclerosis;

- Other spinal cord dysfunctions (e.g., tumors, injuries);

- Cerebral strokes;

- Cerebral palsy;

- Inflammation of the membranes of the spinal cord and brain head injuries.

Contraindications for Lioresal use

You should not buy Baclofen in:

- Allergy or intolerance of the formulation’s components.

- Stomach and duodenum ulcers in the acute stage.

- Porphyria.

Dosage and administration

The dose is chosen individually, determining the minimum effective dose, which does not cause adverse reactions. Thus, when you buy generic Baclofen, you must consult a specialist who will prescribe you the dosage.

The medicine is taken with meals to avoid negative effects from the digestive tract.

Caution is needed when raising the dosage especially to persons over 65. If you use a high starting dose or raise the dosage promptly, then adverse effects may occur.

If, after applying the highest advised dosages for six weeks of therapy, the effect is not achieved, the question of the extension/termination of treatment should be decided.

The difference in treatment should always be carried out gradually, lowering the dose over a period of half of a month, except for emergency conditions associated with an overdose or the occurrence of serious negative effects.


- The course should begin with a dosage of 15 mg a day split into several equal doses. Every three days the dosage can be raised by half of the tablet per intake if the medication is well tolerated. The dosage increase is made until the lowest effective dosage is found.

In most individuals, the optimal effect is observed at the use of the daily dosage of 30 mg -75 mg.

The course duration depends on the clinical condition of an individual. The course is ceased by the gradual reduction of the daily dosage.

The medication in the form of oral pills should not be prescribed to children with a bodyweight of less than 33 kg. For the dosages for children, consult a pediatrician.

Dosage adjustments

- In kidney failure, as well as for individuals on dialysis, the dosage should be reduced to 5 mg per day. For individuals with end-stage kidney failure, baclofen can be appointed if the expected benefit exceeds the risk.

0.05 mg/1mL
10 mg/20mL
40 mg/20mL
10 mg
20 mg
5 mg
1 g/1g

Pregnancy and lactation

Contraindicated in pregnancy. FDA category of action on the fetus is not defined. At the time of treatment should stop breastfeeding.

Adverse effects of Lioresal

- From the side of the nervous system and sensory organs: sleepiness, insomnia, vertigo, headache, weakness, fatigue, confusion, imbalance, decreased reaction speed, mental agitation, euphoria, hallucinations, depression, nightmares, convulsions, decreased seizure threshold.

- From the cardiovascular system and blood (hematopoiesis, hemostasis): decreased blood pressure, palpitations, chest pain, collapse.

- From the digestive tract: disgust for food, taste perversion, nausea, vomiting, constipation/diarrhea, dyspeptic symptoms, abdominal pain. From the genitourinary system: urinary retention; in prolonged use - kidney dysfunction.

- From the respiratory system: a feeling of nasal congestion and suffocation.

- Other: muscle pain, rash, itching, swelling, sweating, weight gain, paradoxical reaction.


- With the simultaneous use of Baclofen enhances the action of antihypertensive drugs, ethanol.

- Tricyclic antidepressants enhance diminished muscle tone.

- Levodopa and Carbidopa raise the risk of developing hallucinations, confusion, and agitation.


Symptoms: vomiting, trouble breathing, cramps, coma (after returning to consciousness, muscle hypotension can persist for 72 hours). Treatment: inducing vomiting or gastric lavage, intake of activated coal, therapy to minimize the symptoms.

Special recommendations

-During treatment, Baclofen exacerbates psychotic syndromes, convulsive conditions, dizziness and symptoms of Parkinson's disease, so if patients are prone to such conditions, they must be under constant medical supervision.

-Patients with epilepsy who require concomitant Baclofen therapy require constant clinical monitoring and EEG, since there is a decrease in the effectiveness of anticonvulsants used and changes in the EEG picture.

- The Lioresal should be cautiously used with antihypertensive drugs (interactions are possible).

- Neurological symptoms of an overdose, including confusion, drowsiness, and depression, were observed in individuals with an impaired kidney function who received oral 5 mg baclofen per day. Individuals with kidney failure should be closely supervised to quickly diagnose early symptoms of toxicity.

- You should be especially careful when you order Baclofen for using it with other substances that affect kidney function.

- During sudden drug withdrawal (long period of treatment increases the chance), anxiety and confusion, hallucinations, psychotic reactions, manic, paranoid and convulsive states, and other negative symptoms may occur, spastic conditions may also increase, so the dose should be lowered gradually over half of a month.

- You should be especially careful when treating elderly patients as negative effects are likely to develop in this group of patients. The ability to influence the reaction rate when driving vehicles or other mechanisms.

When you order generic Baclofen, you should know that it may cause dizziness, sleepiness, and vision impairment (see Adverse Reactions Section), which may decrease concentration and attention. Individuals who have experienced such adverse reactions should not drive vehicles or work with other mechanisms.

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Product Reviews:

May / 30 / 2017 BunnieThompson   USA, Texas
  From my experience I can advise, like other products of SunPharma, this is a good working med
Feb / 08 / 2017 Owen Robinson   Australia, Sydney
  Everything was as described
Dec / 23 / 2016 Madison Hill   USA, Virginia
  Arrived in great condition. It works well for me. thanks!

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