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4RX Store > Medication List > Muscle Relaxers drugs > Order Zanaflex online

Muscle Relaxers Medication (Zanaflex)

 
Generic name:
Zanaflex
Brand name:
Tizanidine
Description:
The medication known as Zanaflex is based on the active substance Tizanidine. It is a central-acting muscle relaxant used in painful muscle spasms (for instance, in acute radiculitis pain in the back), and chronic spastic conditions caused by disorders of the central nervous system. There are some restrictions on the medication use and recommendations on the gradual dosage increase. Read the full guide to know all useful information.
Indications:
Chronic convulsive conditions caused by disorders of the central nervous system, Acute muscle cramps of local origin, Ischemic back pain
Benefits:
The medication helps to relieve muscle spasticity in chronic CNS conditions and acute muscle spasms
Manufacture:
Sun Pharma
Sun Pharma
Synonyms:
Splitz, Tizan, Pramiracetam, Sirdalud, Ternelin
 
   
Zanaflex (Generic Tizanidine)
 
Actual product may differ in
appearance from image shown.
 
 
 
 

Order Generic Tizanidine Buy Zanaflex 2mg

 

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$41.79 ($42.11)
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$66.05 ($71.96)
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$98.20 ($111.85)
  $13.65

 

 

 

 

 

 

 

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  $22.90

 

 

 

 

 

 

 

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  Generic Medication guide:

What is Zanaflex and when is it used?

The brand Zanaflex is owned by a certain pharmaceutical company but the formula on which this product is based is known and used by a variety of other companies. The active substance of these identical products is Tizanidine. For instance, if you want to buy Zanaflex cheaper than the branded drug costs at your local drugstores, you can order a generic version from our online drugstore.

Short drug info
Trade names Zanaflex, Sirdalud, and others
Routes of administration By mouth (tablets, capsules)
Pregnancy category
US: C (Risk not ruled out)
Legal status
UK: POM (Prescription only)

US: Rx-only
Bioavailability ~40%
Protein binding ~30%
Metabolism Liver (CYP1A2, 95%)
Elimination half-life 2.54 hours (tizanidine), 20–40 hours (inactive metabolites)
Excretion Urine (60%), feces (20%)

Tizanidine is a centrally acting skeletal muscle relaxant that has a direct effect on the spinal cord, where it inhibits the release of excitatory amino acids that stimulate receptors in the muscles. Thus, polysynaptic signal transmission is suppressed at the level of interneuronal connections in the spinal cord (which is responsible for excessive muscle tone), and excessive muscle tone is lowered.

The formulation is used as an antispasmodic for the treatment of acute, painful muscle spasm and chronic spasticity of the spinal and cerebral origin. Tizanidine reduces resistance to passive movements, suppresses spasm and clonic convulsions, and possibly improves voluntary muscle strength.

What are the indications for Zanaflex use?

- Chronic convulsive conditions caused by disorders of the central nervous system.

- Acute muscle cramps of local origin.

What are the contraindications for Zanaflex use?

You should not buy generic Zanaflex in certain cases such as:

- Hypersensitivity to the formulation’s components.

- Significantly violated liver function.

- Asthenic bulbar paralysis.

- If you use Fluvoxamine or ciprofloxacin.

Dosage and administration

The medication can be taken with food as it doesn’t affect the onset of effect.

Adults should take 2-6 mg three to four times a day. The starting dosage should not be higher than 6 mg three times a day. It should be raised gradually by 2-4 mg once or twice a week.

The effect is usually achieved with the use of 12-24 mg per day split into three to four intakes. The highest daily dosage is 36 mg.

The duration of the course is determined individually. It is preferable that the dosages are also chosen individually by a doctor so you should consult them before you buy Tizanidine.

Dosage adjustments of Zanaflex

In liver and/or kidney function, the dosage should be reduced. The starting dosage is 2 mg once a day. It can be then raised gradually under a doctor’s supervision. If the starting dosage is ineffective, it is advised to first raise the single dosage, and then increase the number of dosages per day if needed.

What adverse reactions can Zanaflex cause?

Adverse reactions of the medication are classified by frequency: very often (in 10% of cases or more), often (from 1 to 10%), infrequently (from 0.1 to 1%), rarely (from 0.01 to 0.1%) very rarely (less than 0.01%). For each group, adverse reactions are presented in order from severe to most severe. - Mental disorders: seldom - hallucinations, insomnia, sleep disorders;

- Nervous system: Often- drowsiness, dizziness;

- Heart: often - bradycardia, vascular disorders; often - arterial hypotension;

- Digestive system: often - dry mouth, seldom - nausea, and dyspeptic disorders;

- Hepatobiliary system: rarely – hepatitis.

- Musculoskeletal system, joints, and connective tissue: seldom - muscle weakness;

- General symptoms: often - fast fatigability;

- Laboratory indicators: Often - lowering of blood pressure; seldom -the increased activity of transaminases in serum.

When using the medication in low doses (recommended for eliminating acute cramps of muscles of local origin), drowsiness, fatigue, dizziness, dry mouth, elevated blood pressure, nausea, dyspeptic manifestations, increased activity of transaminases in the blood serum were noted. As a rule, these reactions were mild, transient.

When using the medication in high doses (recommended for the treatment of spasticity), these adverse reactions were more frequent, they were expressive, but this did not require the abolition of tizanidine. The following adverse reactions were also observed: low blood tension, irregular heartbeat, muscle weakness, insomnia, sleep disorders, liver dysfunction.

Adverse reactions
Zanaflex Tablet Number of patients=264 (%)
Placebo Number of patients=261 (%)
Dryness of the mouth
49
10
Sleepiness
48
10
General weakness
41
16
Dizziness
16
4
Urinary tract infection
10
7
Infection
6
5
Constipation
4
1
Liver test changes
6
2
Vomiting
3
0
Speech disorder
3
0
Blurred vision
3
<3
Urinary frequency
3
2
Flu-like symptoms
3
2
Dyskinesia
3
0
Nervousness
3
<1
Pharyngitis
3
1
Rhinitis
3
2

Overdose

of Zanaflex Symptoms: nausea, vomiting, arterial hypotension, dizziness, coma.

The treatment is symptomatic.

Use during pregnancy or lactation

In an animal experiment, the negative effect of the medication on the fetus has not been established. Controlled studies of the medication use in pregnant women have not been conducted. Therefore, it should not be prescribed in pregnancy, with the exception of situations where the benefits of treatment significantly exceed any risk.

According to experimental studies, in animals a small amount of Tizanidine is excreted in milk so it should not be prescribed during lactation.

Interactions of Zanaflex

Before you buy Tizanidine, you should check with your healthcare provider that you don’t take any drugs it is incompatible with:

- The use of the medication with Fluvoxamine or ciprofloxacin (both drugs are inhibitors of CYP4501A2 in humans) is contraindicated. This combination causes clinically significant prolonged arterial hypotension, which is accompanied by drowsiness, dizziness, and a decrease in psychomotor activity.

- It is not advised to use Tizanidine and other CYP1A2 inhibitors at the same time, in particular, some antiarrhythmic medications (amiodarone, mexiletine, propafenone), cimetidine, some fluoroquinolones (enoxacin, pefloxacin, ciprofloxacin, norfloxacin), rofecoxib, oral contraceptives, and others.

- In simultaneous use with blood tension-lowering medications (including diuretics), arterial hypotension and bradycardia may occur.

- Alcohol and sedatives may increase the sedative effect of Tizanidine.

Special recommendations

- Tizanidine tablets contain lactose. Therefore, it is not recommended to prescribe to patients in the presence of rare hereditary forms of galactose intolerance, significant lactase deficiency or impaired glucose-galactose absorption.

- Elderly patients: Experience with Tizanidine in elderly patients is limited. The study compared the pharmacokinetics of the drug in elderly patients with chronically impaired function and a decrease in kidney clearance from this in healthy young volunteers. An almost 6-fold decrease in the rate of elimination of Tizanidine in elderly patients was found. Since kidney excretion is only a small fraction of Tizanidine clearance, this effect can be explained by age-related changes in metabolic clearance. Therefore, the use of medication in senior patients should be cautious.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Considering adverse reactions, Tizanidine can significantly affect the ability to drive a car or work with mechanisms so you should refrain from such activities when undergoing the treatment course.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
Product Reviews:
   

 
Apr / 09 / 2021 Daniel Ford   USA, North Little Rock
  Package arrived timely, thank you.
   
 
 
Mar / 03 / 2021 Mark Simeon   USA, Southampton
  all is good, thank you
   
 
 
Feb / 24 / 2021 Mark Norris   USA, Andover
  order arrived safely, thanks
   
 
 
Feb / 19 / 2021 Philipp Simeon   USA, San Antonio
  order arrived timely
   
 
 
Aug / 21 / 2018 Joshua Harrison   USA, Wyoming
  Tizanidine was prescribed in 2016 to help relieve pain caused by spinal stenosis at the top and bottom of my spine. One 2 mg tab was prescribed for 3 times a day. It relieves my pain enough to help me sleep. The drug seems effective and has no untoward side effects for me.
   
 


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