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4RX Store > Medication List > Pain Medicine drugs > Order Celebrex online

Pain Medicine Medication (Celebrex)

 
Generic name:
Celebrex
Brand name:
Celecoxib
Description:
The medication known as Celebrex is based on the active substance Celecoxib with anti-inflammatory, painkiller and anti-fever effects. The medication is also sold under other names which you can find looking for Celecoxib or generic Celebrex. The indications for the medication use are painful sensations in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and psoriatic arthritis. The medication can be used by adults and individuals older than 65 years of age but it is not given to children. Find out about the medication’s dosages, side effects, and other useful information from the full guide.
Indications:
Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Psoriatic arthritis
Benefits:
The medication helps to relieve pain in different conditions quickly and effectively
Manufacture:
Cipla - Caring for life
Cipla - Caring for life
Synonyms:
Celdol, Celedol, Cobix, Zycel, Celebra
 
   
Celebrex (Generic Celecoxib)
 
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  Generic Medication guide:

What is Celebrex and when is it used?

Celebrex is a brand of Pfizer. The active substance of this product is Celecoxib which is an anti-inflammatory, antipyretic, and analgesic agent.

If you wish to buy Celebrex at a lower than the regular price, you should opt for a generic medication. For instance, at our drugstore, you can get the same product sold under a different name made by Cipla.

Celebrex has anti-inflammatory, painkiller and anti-fever activity. The principle of action of the formulation is the suppression of the synthesis of prostaglandins by selective inhibition of the COX-2 enzyme (cyclooxygenase), which is involved in inflammation.

Short drug info
Trade names Celebrex, Onsenal, others
Routes of administration By mouth
Pregnancy category
AU: B3

US: C (Risk not ruled out)
Legal status
AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only
Bioavailability Unknown
Protein binding 97% (mainly to serum albumin)
Metabolism Liver (mainly CYP2C9)
Elimination half-life 7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)
Excretion Faeces (57%), urine (27%)

The agent is well absorbed when taken orally. After taking one dosage from 100 to 200 mg, the highest plasma level is reached on average in three hours and is proportional to the doses. Celebrex is metabolized in the liver with the participation of the cytochrome P-450 isoenzyme system.

It is washed out mainly with bile in the form of metabolites.

When is Celebrex used?

You can buy generic Celebrex for pain relief in:

- Various types of arthritis;

- Ankylosing spondylitis;

- Psoriatic arthritis.

Contraindications for Celebrex use

- Intolerance of the ingredients of the formulation or sulfonamides in general.

- Allergy (bronchospasm, rhinitis, urticaria) to other NSAIDs in history;

- Age below 18 years;

- Pregnancy and lactation.

The formulation must not be used for post-surgery pain in coronary artery bypass.

The use is possible if a healthcare provider approves in:

- Digestive tract ulcer (including a history);

- History of digestive bleeding;

- Simultaneous use with warfarin and other anticoagulants, CYP2C9 inhibitors;

- Swelling;

- Moderate liver failure.

Dosages of Celebrex

The pills are taken by mouth with a full glass of water. The medication can be taken with or without food. To prevent the negative impact on the stomach, it is better to take it after a meal.

During the therapy, the minimum effective dose should be used. The length of the course is set by a healthcare provider and is preferably short.

- For osteoarthritis: 100 mg is taken twice a day or 200 mg once a day.

- For rheumatoid arthritis: 100 mg is taken twice a day. If required, the dose can be raised to 200 mg twice a day.

The highest daily dosage must not exceed 400 mg.

Individuals over 65 years of age do not need a dosage lowering. But in older individuals with a bodyweight of less than 50 kg, the therapy should be started with the minimum recommended dosage.

The maximum course of treatment is 2 weeks. If the desired result is not achieved, the medication must be discontinued.

Your doctor may prescribe you another dosage regimen based on your individual features and condition. Thus, even though you can buy Celecoxib without Rx from our drugstore, we strongly recommend you to consult your healthcare provider first.

Adverse reactions of Celebrex

Adverse reactions
Celebrex Number of patients=4146 (%)
Placebo Number of patients=1864 (%)
Pain in the abdomen
4.1
2.8
Diarrhea
5.6
3.8
Indigestion
8.8
6.2
Bloating
2.2
1.0
Nausea
3.5
4.2
Back Pain
2.8
3.6
Swelling
2.1
1.1
Dizziness
2.0
1.7
Headache
15.8
20.2
Insomnia
2.3
2.3
Flu-like symptoms
2.3
1.1
Nasal discharges
2.0
1.3

- Immune system: strengthening of allergies, very rarely - angioedema, and anaphylaxis.

- Mental: insomnia, anxiety, drowsiness, very rarely - confusion, hallucinations.

- Nervous system: dizziness, muscle hypertonicity.

- Cardiovascular system: swelling, high arterial tension, arrhythmia, rapid heartbeat, hot flashes, very rarely - chronic heart failure, vasculitis.

- Breathing system: bronchitis, cough, sore throat, nasal congestion, respiratory tract infection.

- Gastrointestinal tract: pain in the abdomen, diarrhea, indigestion, bloating, dental diseases, vomiting, rarely - gastric and duodenal ulcers, esophageal ulcers, bowel perforation, pancreatitis, digestive tract bleeding.

- Hepatobiliary system: very rarely - an elevation of liver enzymes levels, hepatitis, liver failure. - Skin: itching, rash, alopecia, urticaria, very rarely - bulbous rashes, peeling of the skin, photosensitivity.

- Urinary tract: infections, very rarely - acute kidney failure, interstitial nephritis.

- Common manifestations: flu-like manifestations.

- Sensory organs: blurred vision, tinnitus.

- Reproductive system: very rarely - menstrual disorders.

Overdose of Celebrex

In case of overdose, sleepiness, nausea, vomiting, pain in the upper abdomen, digestive tract bleeding, and anaphylactic shock can develop. Therapy implies the relief of symptoms and supportive therapy for severe cases. Dialysis is not effective.

Interaction with other medicines

Before you order Celebrex, make sure to check with your physician that you don’t take any medicines incompatible with this drug.

- Celecoxib is metabolized with the participation of cytochrome P450 CYP2C9. If an individual has low CYP2C9 activity, the medication should be prescribed carefully due to a significant rise in the level of the formulation in the blood due to a drop in metabolic clearance.

- The formulation can interact with medicines that are metabolized with CYP2D6.

- In the use of warfarin or similar medicines with Celebrex, cases of severe and even fatal bleeding can sometimes be observed. Due to the fact that when taking Celecoxib, there is an elongation of the prothrombin time, after the start of use or when the dose of Celebrex is changed, anticoagulant activity should be observed.

- The simultaneous use of Fluconazole in a dosage of 200 mg once a day leads to a two-fold elevation of the plasma level of Celebrex. This raise is observed due to the inhibition of medication metabolism by Fluconazole. In individuals receiving a CYP2C9 inhibitor, Fluconazole, Celebrex use should be started with the minimum recommended dose.

- Prostaglandin inhibitors may reduce the tension-lowering effect of ACE inhibitors. -In some individuals, NSAIDs may diminish the effect of diuretics. - Plasma lithium concentrations increase by about 17% due to simultaneous use with Celecoxib. Careful monitoring is required for patients taking lithium with Celecoxib.

Precautions for Celebrex use

- NSAIDs, including Celecoxib, raise the danger of serious adverse reactions on the part of the digestive tract such as bleeding, ulcers formation, and others. These complications can occur at any time without warning signs, a fatal outcome is possible. Elderly individuals have a higher risk of serious complications; the likelihood of these complications also increases with prolonged use.

- In senior patients, in low bodyweight, in symptoms of heart failure and with the failed liver function of moderate severity, therapy should be started with minimal doses. - In some individuals taking Celebrex, fluid retention and edema were observed, so it should be used carefully in any heart conditions and other diseases associated with fluid retention.

- During the therapy, it is necessary to control peripheral blood and the functional state of the liver and kidneys.

- It is necessary to refrain from potentially hazardous activities that require increased attention, as there may be a violation of accommodation and a longer reaction time.

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Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
Product Reviews:
   

 
Jun / 04 / 2018 Charles Moore   USA, Biscoe
  Very fast all good thank you!
   
 


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