Generic Medication guide:
What is Paracip and when is it used?
Paracetamol is a medication from the group of painkillers and fever-reducers, is the main metabolite of phenacetin, which quickly turns into the body and causes a painkiller effect.
This medication was synthesized by Harmon Northrop Morse in 1873. It entered clinical practice in 1950. As a separate drug it was registered in the United States in 1955. Nowadays, the medication is marketed under a variety of names. To buy Paracetamol cheap, do not opt for the known brands as Tylenol. Getting a generic from our online drugstore is cheaper and you will get the same effect.
Paracetamol is excellently tolerated and the risk of developing dangerous complications is minimal. And the existence of various dosage forms - tablets, effervescent tablets, capsules, suspension, syrup, suppositories, and solution for infusion.
The unique principle of action of paracetamol is the main distinguishing feature of NSAIDs and opioids. Paracetamol affects the activity of the cyclooxygenase enzyme, but to a large extent, one of its variations is COX-3, the activity of which is justified in the central nervous system. Since the mechanisms of action are different, there is the possibility of the combined use of NSAIDs and paracetamol, which significantly increases the expected pharmacotherapeutic effect and allows the use of NSAIDs in lower doses.
It is worth noting the relative safety of the long-term use of the medication in the therapy of osteoarthritis of large joints and hands, this provides the proper control of pain and improving the quality of life of patients with this pathology.
It is used for toothache, rheumatoid pain, migraine, to relieve symptoms of fever and muscle pain with colds and flu. Paracetamol is excellently tolerated and the risk of developing dangerous complications is minimal. And the existence of various dosage forms - tablets, effervescent tablets, capsules, suspension, syrup, suppositories, and solution for infusion.
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Short drug info
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Trade names |
Tylenol, Panadol, Acetaminophen, others |
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Routes of administration |
By mouth |
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Pregnancy category |
AU: A US: C (Risk not ruled out) In general: not recommended unless the benefits are greater than potential risks. |
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Legal status |
AU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC |
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Bioavailability |
63–89% |
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Protein binding |
10–25% |
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Metabolism |
Predominantly in the liver |
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Onset of action |
Pain relief onset by route: By mouth – 37 minutes Buccal – 15 minutes Intravenous – 8 minutes |
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Elimination half-life |
1–4 hours |
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Elimination |
Urine (85–90%) |
When can be Paracetamol used?
You can buy generic Paracetamol for:
- Headache, including migraine;
- Toothache;
- Backache;
- Rheumatic pain;
- Muscle pain;
- Menstrual cramps;
- Arthritis pain;
- Fever and pain in colds and flu.
When is Paracetamol contraindicated to be used?
You should not buy Paracip in:
- Allergy or intolerance of Paracetamol.
- Severe liver or kidneys diseases;
- Congenital hyperbilirubinemia;
- Glucose-6-phosphate dehydrogenase deficiency;
- Alcohol abuse;
- Blood diseases;
- Gilbert's syndrome; severe anemia (low hemoglobin);
-Leukopenia.
How is Paracip used?
The formulation available on this webpage is for oral use. Here you can fine the general instructions. If you want to get the medication in a different form, please read the respective instruction.
Adults and kids older than twelve years: 1-2 pills up to four times a day. The highest daily dosage is eight pills or 4 g.
Kids aged 6-12 years are given a half of a tablet or a whole tablet up to four times a day. The longest period of use in kids without consulting a pediatrician is 3 days.
The dosages must be taken at least 4 hours apart. Do not take the higher dosages or use other medicines based on Paracetamol.
Overdose of Paracip
Symptoms of an overdose in the first day are nausea, vomiting, loss of appetite and pain in the stomach. Within twelve hours, the symptoms of liver dysfunction also can be observed. It can also cause kidney failure and heart function disturbances. Other symptoms include dizziness, drowsiness, and others. In general, malaise and the intensification of listed adverse effects occur.
To eliminate the medication after an acute overdose vomiting, gastric lavage and activated carbon or other sorbents are used. If the symptoms have already developed, medical assistance and hospitalization are required as serious measures and monitoring of vital signs are required.
Adverse effects of Paracetamol by body systems
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Body system |
Adverse reaction |
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Immune system |
Anaphylaxis, hypersensitivity reactions, including skin itching, rashes on the skin and mucous membranes (usually generalized rashes, erythematous rashes, urticaria), angioedema, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis ); |
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Digestive system |
Nausea, pain in the stomach; |
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Endocrine system |
Hypoglycemia, up to hypoglycemic coma; |
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Blood system and lymphatic system |
Thrombocytopenia, agranulocytosis, anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia, bruising or bleeding; |
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Respiratory system |
Bronchospasm in patients sensitive to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs; |
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Hepatobiliary system |
Impaired liver function, increased activity of liver enzymes, usually without the development of jaundice. |
Use during pregnancy or lactation
In general, the medication is highly not recommended during pregnancy and breastfeeding but if a qualified healthcare provider believes that the benefits are higher than the risks, Paracetamol can be appointed.
Interactions of Paracetamol
When you buy generic Paracip, remember that it can be used not with any medicines – with some of them it can severely harm your health.
- The medication’s level increases in the blood plasma and the likelihood of adverse effects raises in the use with Metoclopramide and Domperidone.
- The level of the medication within the body is lowered when it is used with cholestyramine.
- Paracetamol enhances the effect of blood thinners which can result in bleeding in their simultaneous use.
- Barbiturates reduce the fever-reducing effect of paracetamol. - Anticonvulsants (including Phenytoin, Carbamazepine, etc.) enhance the toxic effect of paracetamol on the liver.
- In the simultaneous use of the medication with medicines that negatively affect the liver, they mutually enhance each other’s toxic effects on the liver.
- Paracetamol diminishes the effectiveness of diuretics.
- Do not use simultaneously with alcohol.
Special instructions
- If you have liver and/or kidney diseases, before you order Paracetamol, consult a doctor.
- If you use blood thinners, do not use Paracetamol without prior consulting a doctor. - The risk of the negative effect on the liver is higher in individuals who abuse alcohol and/or have liver diseases.
- The medication may affect the results of laboratory tests of blood glucose and uric acid.
- In severe infections, such as sepsis, which are accompanied by a decrease in glutathione, taking paracetamol elevates the risk of metabolic acidosis. Symptoms of metabolic acidosis are rapid or troubled breathing, nausea, vomiting, and loss of appetite. If these symptoms appear, consult a doctor immediately.
- Do not exceed the indicated doses.
- Do not take the medication with other agents containing paracetamol.
- If you want to order generic Paracetamol and use it for arthritis which implies a long-term course, consult a doctor first.
- If symptoms of the disease you are treating with the medication persist, consult a doctor.
Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section
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