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4RX Store > Medication List > Skin Care drugs > Order Accutane online

Skin Care Medication (Accutane)

Generic name:
Brand name:
The medication known as Accutane is based on Isotretinoin, a retinoid that normalizes skin sebum production and is used for severe acne. The drug is highly effective when other traditional methods fail but it is strictly contraindicated during pregnancy so it must be cautiously used by women of reproductive age. For the information about other precautions, dosages, adverse effects, and so on, read our full guide.
Severe acne, Prevention of certain forms of skin cancer
The medication is highly effective against severe acne when the first-line therapy is ineffective
Cipla - Caring for life
Cipla - Caring for life
Accutane (Generic Isotretinoin)
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  Generic Medication guide:

What is Accutane and when is it used?

Accutane is a brand of the formulation produced by the Swiss pharmaceutical company. Its active agent is Isotretinoin. The medication is mainly used to treat severe forms of acne but it is also used for the prophylaxis of certain skin cancer types and other types of cancer.

The branded medication is quite expensive so if you want to save when you buy Accutane you can get a generic version instead, i.e. the same medication made by other companies. We offer you the medication made by the world-known generic-making company Cipla.

Short drug info
Trade names Accutane, Roaccutane, others
Routes of administration By mouth, topical
Pregnancy category

AU: X (High risk)

US: X (Contraindicated)

Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only In general:

Rx (Prescription only)

Bioavailability Variable
Protein binding 99.9%
Metabolism Liver
Elimination half-life 10–20 hours
Excretion Urine and feces

The medication is a systemic retinoid which allows fully suppressing the excess production of sebum, normalizing the regenerative functions of the skin, thereby curing acne and seborrhea.

The action of Isotretinoin on the human body has not been fully studied, however, it is known that it affects almost all systems of the human body, including gastrointestinal, musculoskeletal, nervous, internal secretion, and urogenital. The use of the formulation is possible only as directed by a doctor.

When must not Accutane be used?

You must not buy generic Accutane and use it if you are pregnant, are planning pregnancy, or don’t use reliable means of contraception (condoms plus hormonal). The formulation is strictly prohibited in pregnancy as it is certain to cause grave defects of the fetus. Before a woman of reproductive age is appointed Accutane, she must be examined by a specialist checked for meeting all of the parameters of the pregnancy prevention program, and only if she meets them she can use the drug.

Other contraindications are:

- Allergy or intolerance of any components of the formulation;

- Liver failure;

- Severe hyperlipidemia;

- Hypervitaminosis A;

- Soy allergy.

How is Accutane used?

Before you buy Isotretinoin, you should acknowledge that the therapy must be appointed by a healthcare specialist and followed strictly. Besides, frequent monitoring is needed, especially for women of fertile age.

Capsules are taken with meals 1-2 times a day.

Regularly, the course is begun with a dose of 0.5 mg per kilogram of the body weight daily. However, based on the reaction and tolerance of the formulation adjustment can be made. Usually, the dose for maintenance therapy is from 0.5 to 1 milligram per kilogram of the body weight a day.

Accutane dosing by body weight

Body weight (Kilograms)
0.5 mg/kg
1 mg/kg
40 kg
50 kg
60 kg
70 kg
80 kg
90 kg
100 kg

The effect of the course and lack of relapses are contingent on the total appointed dosage and not the length of the course or the daily dose. A course of 4-6 months is usually sufficient to reach remission.

In most cases, for the complete solution of the problem, one course is sufficient. However, if a severe relapse occurs, the course can be repeated but two months after the termination of the first one since during this time the drug is still acting and improvement can occur without a second course.

Dosage adjustments of Accutane

In severe kidney failure, the course should begin with a lower dosage (for example, 10 mg/day), and then raised to 1 mg /kg/day or to the highest well-tolerated dosage. Individuals who develop severe intolerance of the standard dosage can continue the course with a lower dosage but in this case, the duration of therapy is longer and the risk of relapse is higher.


The negative effects include headache, nausea, sleepiness, irritability, and itching. These effects are reversible and disappear without the need for treatment.

What adverse reactions can Accutane cause?

When you buy generic Isotretinoin, you need to know that it can cause certain adverse reactions. They are usually dose-dependent, the higher is the dosage, the bigger is the likelihood of negative effects. Negative reactions are usually reversible after lowering of the dosage or cessation of the course, but some may persist. The negative effects that are most frequently reported during the course are dryness of the skin, mucous membranes, including lips, nasal cavity (nosebleeds), and conjunctivitis.

Other possible negative effects are:

- Very rarely - infections of the skin and mucous membranes.

- Anemia, thrombocytopenia, thrombocytosis; often neutropenia; very rarely - lymphadenopathy.

- Allergic reactions from the skin, anaphylaxis. - Metabolic, metabolic disorders: diabetes, hyperuricemia.

- Mental disorders: rarely - depression, increased depression, anxiety, mood changes; - Often - headache; sleepiness, dizziness. - Vascular disorders: very rarely – vasculitis;

- From the gastrointestinal tract: very rarely - colitis, ileitis, dry throat, digestive tract bleeding, hemorrhagic diarrhea, nausea, pancreatitis, an elevation in liver transaminases.

- Muscle and joints pain.

- Laboratory indicators: very often - hypertriglyceridemia, a decrease in the level of high-density lipoproteins; often - hypercholesterolemia, hyperglycemia, hematuria.

Can Accutane be used with other drugs?

Before you order generic Accutane, inform your healthcare provider about any other medicines you use.

- The use of the medicating with other retinoids elevates the risk of hypervitaminosis with vitamin A and respective negative effects.

- The use of the medication with tetracyclines is contraindicated as it can raise intracranial pressure. - Accutane can lower the effect of progesterone so you must not rely on the contraceptives which effect is mainly based on this hormone.

- The risk of sunburns is increased in the use of the medication with such medicines as sulfonamides, tetracyclines, thiazide diuretics, and other medicines that cause sensitivity to light.

- The effect of Accutane-based ointment is lowered in the use of tetracyclines or the local application of glucocorticoids.

Special recommendations

You must not order Accutane if you are a woman of reproductive age unless all of the below-listed conditions are met:

- You are diagnosed with severe acne that is not eliminated with the primary methods of treatment (systemic antibiotic therapy, local treatment);

- You acknowledge the risk of the formulation use in pregnancy;

- You agree to visit a doctor every month;

- You are able to avoid getting pregnant by continuously using reliable contraceptives for one month prior to the course, throughout the course and for a month after the end of course; it is desirable to use simultaneously 2 different methods of contraception, including condoms; even in lack of menstruation, a woman should use reliable contraception;

- You must confirm that you understand the essence of the measures;

- You agree to conduct a pregnancy test prior, throughout and five weeks after the course;

- You should begin the therapy only on the 2nd or 3rd day of the next normal menstrual cycle.

- A pregnancy test is carried out on the day of appointment of Accutane or three days before the patient’s visit to the doctor. The specialist should register the test results.

- The patient should visit the doctor every 28 days. The requirement for monthly pregnancy test is determined in accordance with local practice and taking into account sexual activity and the history of recent menstrual cycles (abnormal periods, lack of menstruation).

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Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section


Product Reviews:

Nov / 10 / 2021 Jeffrey Borges   Australia, Melbourne
  My 3d order arrived on time, as usual!
Sep / 20 / 2021 Dana Miller   United Kingdom, Cardiff
  Everything was as promised.
Sep / 21 / 2017 Matthew Shear   USA, Texas
  Good price and fast shipping.
Aug / 24 / 2017 Joshua Witsman   USA, Prattville
  Got the item thanks

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