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4RX Store > Medication List > Generic Stop Smoking drugs

Generic Stop Smoking drugs


This section of our online drugstore is dedicated to the most effective means to aid tobacco smoking cessation. Cessation of smoking or other types of tobacco consumption can be complicated because of the addiction caused by nicotine.


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Based on the statistics provided to the International Classification of Diseases of the 10th revision developed by the World Health Organization, tobacco refers to physiological behavioral disorders related to the use of psychoactive substances.

According to surveys, around 70% of tobacco smokers wish to quit smoking and around half of the smokers report quitting attempts in recent year.

Tobacco causes the death of about 50% of people who use it. According to WHO, as of 2014, tobacco causes about 6 million deaths annually, of which more than 600 thousand are non-smokers who are affected by second-hand smoke, i.e. passive smoking. The remaining more than 5 million are smokers themselves. To date, in the world, there are about 1 billion smokers. About 80% of them live in low- and middle-income countries.

How smoking cessation affects health?

The American Cancer Research Society has observed the following effects of refusing cigarettes smoking:

- After twenty minutes - a lowering of arterial tension and speed of heartbeat raised due to the last cigarette smoked;

- Within twelve hours, the level of carbon monoxide in the blood decreases to normal;

- After half of the month to 3 months, blood circulation improves and functional indicators of the respiratory system increase;

- After 1–9 months, cough and breathing difficulties decrease, the function of the ciliated epithelium is restored, and vulnerability to bronchopulmonary infections decreases;

- Within one year, the risk of coronary heart disease is dropped twofold;

- After two years, the risk of a stroke can drop to the usual level of a non-smoker; -After five years, the risks of developing cancer of the oral cavity, throat, esophagus, and bladder are dropped two times. For females who dropped the bad habit, the likelihood of cervical cancer is reduced to the level of a non-smoker;

- After ten years, the likelihood of death from lung cancer is dropped by half (compared with continued smoking). The danger of cancer of the larynx and pancreas also diminishes;

- After fifteen years, the risk of coronary artery disease returns to the same level as of people who have never been smokers.

- Among other effects, there is a drop in the risk of diabetes, increased exercise tolerance, improved well-being, increased potency in men, and improved reproductive function in women. The health effect of smoking cessation in youth is higher, but at any age, quitting allows you to save years of life that would be lost when smoking continued. Methods used for smoking cessation

- Smoking cessation without assistance The most common cold turkey self-cessation method is abrupt, definitive cessation, for instance, with Allen Carr's method.

But based on the data of the American Cancer Society, only 4 to 7% of smokers are able to quit in one try without medication or psychological assistance.

Medications for smoking cessation

According to the conclusion of the Mayo Clinic professors Muhamad Elrashidi and Jon Ebbert, the two most effective medications for tobacco dependence (for 2014) are Varenicline (Chantix) and combination (for example, patch + chewing gum) nicotine replacement therapy.

Type of the drug
Active agent
Trade name
Nicotine replacement therapy
Nicorette, Thrive, Commit, Nicotrol, Nicoderm, Habitrol, Niquitin
Nicotinic receptor agonists
Champix, Chantix
Nicotinic receptor agonists
Tabex, Desmoxan
Atypical antidepressants
Velbutrin, Zyban
Tricyclic antidepressants
Aventyl, Pamelor
Antihypertensive drugs
Catapres, Dixarit

According to a Cochrane review of whether antidepressants help smokers trying to quit smoking, using bupropion raises the chances of a successful quit attempt. The evidence for this is of high quality, 44 trials were conducted with 13 thousand participants. True, the observation period was limited to 6 months. The use of nortriptyline also raises the number of people who quit smoking, but here the evidence is only of average quality since only six studies were conducted.

- Nicotine replacement drugs include, in particular, Nicorette. Usually used patches containing 21 mg (effective for 24 hours) or 15 mg nicotine (effective during the wakeful period of 16 hours), chewing gum (2 and 4 mg nicotine, about 20 pieces per day) or absorbable tablets, inhalers. Sometimes a combination of different forms of nicotine replacement is used, as well as a combination with other drugs.

- Bupropion (trade names "Velbutrin", "Zyban") is an atypical antidepressant that is also used to treat nicotine addiction. A known side effect of taking the drug is depression and suicidal thoughts. In 2014, reports appeared in the Canadian press that the use of bupropion was much more dangerous than previously thought, precisely because of suicidal thoughts.

- Partial nicotinic receptor agonists: Varenicline (Champix), launched on the market in 2008, which is a partial agonist of nicotinic receptors, offers great promise, but its use in some patients is fraught with side effects, including from the nervous system.

- Citizine (Tabex), an alkaloid isolated from Russian broom. The drug Tabex was actively used to quit smoking in the countries of Central and Eastern Europe, beginning in the 60s. However, in Western countries, he was practically not seen, largely due to the fact that the results of the studies were not published in English. Modern researchers note as a virtue the relatively low cost of producing drugs based on cytisine, which, unlike its derivative of varenicline, is not artificially synthesized and is extracted directly from plant materials. Unlike drugs manufactured in the West and having undergone expensive clinical trials, Tabex has long remained a drug with a favorable clinical history, but practically unnoticed at the international level, since evidence of its effectiveness was collected in the 60-70s in the Warsaw block countries, insufficiently consistent with Western standards for clinical trials. In 2008, there was one trial that compared the effects of cytisine and placebo and found significantly higher levels of smoking cessation after two years. Some researchers question the effectiveness of cytisine.

Non-drug smoking cessation methods

The doctor’s advice to quit smoking is a useful intervention in modern medicine, even with a small percentage of smokers following this advice. Clarification of the effects of smoking, help, and encouragement, support for motivation - all these factors improve the success of smoking cessation.

There are also various courses and programs, both one-day and multi-day, which are aimed mainly at overcoming the psychological dependence on smoking.

A similar way to overcome smoking addiction is to work with a psychologist, a specialist in the field of chemical dependency.

Smoking cessation drugs you can buy at our drugstore:

- Chantix (Varenicline) by Pfizer is an agonist of nicotine receptors. It is one of the most popular smoking cessation drugs on the market. It both suppresses the craving for smoking and makes it less pleasant even for a long-time smoker.

- Zyban (Bupropion) is an antidepressant which helps suppressing addiction and cravings. It is also used for compulsive overeating and impotence caused by psychological problems.

You can buy drugs to stop smoking from our med store without prescription. But if you use any potent medicines, you should consult your doctor first to be sure that these medicines won’t negatively interact.

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