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4RX Store > Medication List > Stop Smoking drugs > Order Zyban online

Stop Smoking Medication (Zyban)

Generic name:
Brand name:
The medication named Zyban is based on Bupropion. It is a antidepressant that inhibits the reuptake of norepinephrine and dopamine which helps in coping with depression with apathy, ADHD, smoking withdrawal, erectile dysfunction caused by mental problems, and compulsive overeating. Find out how to use the medication including for how long, on what dosages, how to avoid adverse effects, and so on, from the full guide below.
Smoking cessation aid, Treatment of depression with low productivity, Treatment of erectile dysfunction of psychological nature, Treatment of obesity caused by compulsive eating, ADHD
The medication helps to quit smoking and get rid of other bad habits effectively without withdrawal syndrome
Sun Pharmaceutical Industries Ltd.
Sun Pharmaceutical Industries Ltd.
Bupron, Burporn, Wellbatrin
Zyban (Generic Bupropion)
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Order Generic Bupropion Buy Zyban 150mg


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  Generic Medication guide:

What is Zyban and when is it appointed?

Zyban is one of the names under which a medicinal substance called Bupropion is marketed. It is an antidepressant, analeptic, a central nervous system stimulant used to treat psychological nicotine addiction, reduce the negative symptoms that occur when weaning from cigarettes. Also, the medication is intended for the treatment of depression accompanied by apathy and lethargy, obesity, and erectile dysfunction of psychological nature.

Short drug info
Trade names Wellbutrin, Zyban, others
Routes of administration Oral
Pregnancy category

AU: B2

US: C (Risk not ruled out)

Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only

Protein binding 84% (bupropion), 77% (hydroxybupropion metabolite), 42% (threohydrobupropion metabolite)
Metabolism Liver
Elimination half-life 12–30 hours
Excretion Renal (87%; 0.5% unchanged), fecal (10%)

If you have any of the problems the medication is used for, you can buy Zyban analog from our pharmacy that has the same composition and renders the same effect but is priced cheaper than the branded medication.

Today, Bupropion is the fourth most frequently used drug in the world for the treatment of smoking addiction. Unlike conventional SSRIs, it acts as a selective inhibitor of the reuptake of dopamine and norepinephrine.

The medicine is available in the form of tablets that contain the active substance Bupropion hydrochloride in the amount of 75, 100 and 150 mg which are easily divided into halves. The tablets have a blue color and a bitter taste.

The active substance when it enters the body affects the psychological attraction of a person to nicotine. The antidepressant effect reduces the manifestation of unpleasant symptoms that are associated with the so-called withdrawal syndrome.

The drug lowers the threshold of convulsive readiness of the brain, prevents the gain in body weight, which often occurs at the beginning of smoking cessation.

The drug is prescribed in the following cases:

- Treatment of nicotine addiction.

- Therapy for obesity and erectile dysfunction.

- Elimination of serous affective disorders and neuropathic pains.

- As an auxiliary component in the treatment of Crohn's disease and psoriasis.

- Therapy for ADHD (attention deficit hyperactivity disorder).

If you want to buy generic Zyban for several months ahead, keep in mind that it should be stored in a dry, dark place where children and persons with mental disorders cannot reach. Air temperature should not exceed twenty-five degrees Celsius (77F). The shelf life of the drug is two years.

How does Bupropion act?

The drug suppresses the reuptake of norepinephrine and dopamine. Once in the human body, the drug is transformed into several metabolites, which differ in their effect. The medication helps to improve the nutrition of the brain neurons; it is an antagonist of nicotinic acetylcholine receptors, which significantly reduces the threshold of convulsive activity of the brain.

When taking the drug, the state of health significantly improves, there is a lack of need for the consumption of nicotine or food in large quantities. The formulation is, in general, well tolerated by patients.

The bioavailability of Bupropion is 20% and it is quite firmly bound to plasma proteins. Bupropion is metabolized in the liver tissue, after twenty hours, half the substance is excreted in the urine, and 10% with feces. But doctors say that the metabolism of the drug is variable, its effective dose, which is absorbed in the body by patients receiving the same dosage can be five times higher or lower based on the individual features.

Dosage and therapy regimen

When you buy Bupropion, you should know that the course of therapy should be at least seven weeks. In this case, the first six days it is necessary to take once 150 mg of the drug, for this - use the appropriate number of tablets, which come in different dosages. If the tablet contains 150 mg of active substance, take one tablet per day if 75 mg - two tablets.

Starting from the seventh day take 150 mg twice a day. Tablets are not recommended to be chewed and grinded, drink them with half a glass of water. In the second week of using the drug, you need to decide on the day of smoking is cessation, the dosage of the tablets after that does not change, continue to take them in the same mode.

The effect of the drug is felt already after two weeks from the start of administration, in some cases it occurs later.

The maximum single dose of the tablets is 450 mg. The dosage is taken strictly once a day at the same time, preferably in the morning. In severe cases, the dosage is increased on the third day of treatment or after two weeks by 100 mg.

Dosage adjustment of Bupropion in liver/kidney failure

- If a person has kidney failure, it is recommended to start therapy with a minimum dosage of 75 milligrams per day, since the active substance has the ability to accumulate in the body.

- In liver pathologies, the time between doses of the drug needs to be increased; in this case, tablets are taken once every two days at a dosage of 150 milligrams.

Contraindications for Bupropion use

It is strictly forbidden to use the drug for those who have epilepsy of any form, as well as for individuals prone to seizures of any genesis.

Bupropion is also contraindicated for:

- Children under eighteen years of age.

- People of advanced age (over 60 years old).

- Pregnant women.

- During breastfeeding.

- Any type of diabetes mellitus.

- Persons with severe chronic kidney and liver pathologies.

- People with Parkinson's and Alzheimer's disease.

- Diagnosed cancer and autoimmune pathologies.

- A tendency to allergic manifestations that require the supervision of a doctor.

- Severe hypertension.

- Withdrawal symptoms, anorexia nervosa or bulimia, a brain tumor.

Restrictions on use

There are some restrictions on use according to the instructions. Carefully read them and consult your doctor if needed before you buy generic Bupropion. It cannot be used simultaneously with such drugs:

- Any antidepressants, MAO inhibitors, for example, Iproniazide, Amitriptyline, and others.

- Glucocorticosteroids in any dosage form.

- Antibacterial drugs of the fluoroquinolone group, for example, Ciprolet and its analogs.

- Anxiolytics: Xanax, Alprazolam, and others.

- Drugs for Parkinson's disease.

- Insulin and hypoglycemic agents.

- Beta-blockers and heart medications.

- If you take Bupropion with Razagilin together, the effectiveness of the first drug will decrease several times. Therefore, an increase in dosage may be required, but it should not exceed 450 milligrams per day. Particular care must be taken in use the drug with Levodopa and Amantalin since the development of neuropsychiatric reactions is possible.

- When combined with a transdermal nicotine system, an increase in blood pressure is possible. 

Negative consequences

In the absence of a tendency to allergic manifestations, the drug is well tolerated by patients. In some cases, the following side effects may occur:

- Diarrhea and nausea;

- Hand tremor and dizziness;

- Deviation from normal walking (gait abnormality);

- Dry mouth;

- Pain in the abdomen;

- Mood swings;

- Impaired appetite;

- Urticaria, acne, which usually disappears a week after the start of therapy;

- Strengthening of nerve tics in people with Tourette syndrome and ADHD;

- Hypertension;

- Tinnitus;

- Epileptic seizures.

Side effects reported by at least 1% of patients and at a higher frequency than placebo in the dosage-response tests

Adverse effect
ZYBAN 100 to 300 mg/day
(number of patients = 461) %
(number of patients = 150) %
Neck pain
Allergic reaction
Hot flashes
High blood pressure
Dryness of the mouth
Enhanced appetite
Loss of appetite
Join pain
Muscle pain
Thinking abnormality
Dryness of the skin
Taste violation

If the symptoms do not go away after seven to ten days or side effects only worsen, you must consult a doctor and tell them for what purpose the medication had been used.

Epileptic seizures are the most common side effect of prolonged use of this drug, so it was previously withdrawn from the market. But after a detailed study of the problem, scientists came to the conclusion that the development of seizures is influenced by large doses of the drug and a low dosage can have an anti-convulsive effect.

According to studies in people with pathologies of the cardiovascular system who took the drug, there was an almost twofold increase in the number of complications. Therefore, it is necessary to take Bupropion with caution if such diseases exist.

A sharp cessation of the use of the drug leads to the development of the so-called withdrawal syndrome, which is manifested by dystonia, irritability, excessive anxiety, headache, and so on. Therefore, the instruction for the use of Bupropion suggests that the medicine should be withdrawn gradually reducing the dosage. But at the end of the course of treatment for nicotine addiction, it is not necessary to reduce the dosage of the drug, it is canceled immediately. In this case, side effects are not observed.

Additional instructions

- In the treatment of nicotine addiction, the drug begins to be used during smoking which increases its effectiveness. In the second week of therapy, it is necessary to determine the day when you plan to give up tobacco but the drug is then continued to be used in the same mode.

- You shouldn’t change the dosage of the medicine yourself, if in doubt, consultation with your doctor is recommended.

- It is strictly forbidden to use the medicine for people with suicidal thoughts. This drug, like any other antidepressant, can provoke the appearance of suicidal thoughts in people younger than twenty-five years old. But in the treatment of nicotine addiction, such symptoms usually do not appear.

- It is noted that in the treatment of nicotine addiction, unusual changes in the patient's behavior, the development of agitation and hostility, or, conversely, depression are possible. But usually, such phenomena disappear after two weeks of using the medication.

- It was also found that the drug can provoke the development of manic syndrome in the treatment of depression. But in general, psychotic symptoms (hallucinations, delusions, and paranoia) in Bupropion develop very rarely.

Overdose of Bupropion

It is recommended to adhere to the dosage of the drug prescribed by the attending physician to reduce the risk of negative consequences and complications even if you order Zyban without Rx online.

In case of an overdose of the drug, the following symptoms are observed:

- Tachycardia and hypertension;

- Drowsiness or, conversely, agitation;

- Nausea with bouts of vomiting;

- Epileptic seizures;

- Visual and auditory hallucinations, delirium;

- Arrhythmia;

- Coma.

It was found that epileptic seizures appear when using the drug at a dosage of 600 mg per day. When using two tablets per day, no negative symptoms were observed.

A special antidote, in this case, is not provided. It is necessary to carry out maintenance therapy, as well as stopping an epileptic seizure by administering an intravenously large dosage of barbiturate. Activated carbon, in this case, is not recommended as this will not be of benefit. Gastric lavage is recommended.

Overdosing usually does not lead to death. In medical practice, one case of cardiac arrest was recorded but without a lethal outcome.

Analogs and reviews

Zyban analogs can have the following names: Bupropion, Bupron, Wellbutrin, and others. The main active ingredient of all these products is Bupropion.

These drugs are the so-called generics of Zyban. All of them undergo mandatory studies (biological, pharmacological and others). Since the drugs are not sold under a well-known brand, they have a lower cost compared to the original drug but are no less effective.

In general, Zyban reviews are positive. Many patients noted the emergence of emotional recovery and vigor, the desire to perform activities. The craving for smoking disappeared already in the first week of taking the drug. Consumers note that the so-called narcotic pleasure does not develop from this remedy. This medication has a good therapeutic effect, so doctors often prescribe the drug to patients who want to get rid of nicotine addiction and/or are suffering from depression.

Besides, there are also Bupropion for weight loss reviews which are also enthusiastic, as it helps to reduce body weight by reducing appetite. In this regard, in recent years, the drug is often abused and misused for the purpose of losing weight, especially by females. Doctors warn that drug abuse can provoke the development of seizures since this side effect depends on the dosage of the drug.

Some patients talked about the appearance of side effects in the first days of therapy but they are usually going away in one to two weeks. In other cases, the drug was not suitable for patients, so the doctor had to prescribe another remedy.

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