Generic Medication guide:
Buying medications online is a wise decision even if you can afford purchasing them at your local drugstores. Some people even cannot buy the drugs their doctor prescribes because in the U.S. their prices are highly exaggerated. Moreover, some medications require a long lasting treatment course that can be ridiculously expensive and every time you need a refill, you would need to go to a doctor for a prescription. Meanwhile, you can buy absolutely the same drugs online cheaper and even without a prescription from your doctor. Cheaper medications are shipped to the U.S. from the countries where they are sold without Rx and at significantly lower prices. Domestic pharmacies do not sell these drugs because they are not registered in the country but it doesn’t mean that they are inferior. They are registered, tested, and certified in other countries where live the same people with the same diseases, who need the same treatment but have lower incomes than people in America.
Since you have found this webpage, we assume that you’ve been looking for a way to buy Generic Dostinex (Cabergoline) online. We are happy to inform you that you have found the right place. We offer the drug at an affordable, reasonable price, and are even willing to send it to you with already covered shipping costs if you order pills for $170 or more. Please read the medication guide that we have prepared for you so you can decide whether it is the right medication for your needs or not.
How the drug was created?
The medication mostly known as Dostinex was first synthesized by the Italian pharmacologists who worked for the Milan-based pharmaceutical company Farmitalia-Carlo Erba in the late 1970s. In 1980, the inventors received the patent for the drug production and marketing. First, the drug was marketed in the Netherlands entering the market in 1992. A year later, the inventor’s company was acquired by Pharmacia drug making company and later, in 2003, became a part of the American global corporation Pfizer. In the U.S., the drug was approved in 1996. Since 2005, when the exclusive patent of the brand owner expired, numerous generics were also approved and started to be sold in the U.S. and other countries.
Short drug info
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Trade names |
Cabaser, Dostinex |
Other names |
Cabergoline |
Pregnancy category |
US: B (No risk in non-human studies) |
Routes of administration |
Oral |
Legal status |
US: Rx-only |
Bioavailability |
First-pass effect seen; absolute bioavailability unknown |
Protein binding |
Moderately bound (40–42%); concentration-independent |
Metabolism |
Hepatic, predominately via hydrolysis of the acylurea bond or the urea moiety |
Elimination half-life |
63–69 hours (estimated) |
Excretion |
Urine (22%), feces (60%) |
When Generic Dostinex (Cabergoline) is prescribed?
The medication is prescribed for a number of conditions both for men and women that require the reduction of prolactin (is a hormone, a protein that is best known for its role in enabling milk production which can also influence other changes in the body) production and concentration in the blood. Already 3 hours after the administration of Generic Cabergoline (Dostinex), a decrease in the blood level of prolactin, which is maintained for from 7 to 28 days in healthy subjects and patients with elevated prolactin, is observed. Your doctor will most likely tell you to buy Generic Dostinex (Cabergoline) in one of the following conditions:
- Hyperprolactinemia (excessively high levels of prolactin in the blood). In women, the condition manifests in infertility, menstrual disturbances (oligomenorrhea, amenorrhea, anovulatory menstrual cycles), and galactorrhea.
- For the suppression of physiological lactation after giving birth because of the unwillingness or inability of a woman to breastfeed, or when there are contraindications for breastfeeding for the mother or a child, after an abortion, or after a stillbirth.
- For the treatment of empty sella syndrome.
- For the treatment of idiopathic hyperprolactinemia (high prolactin level without the obvious reason for its heightened level).
- For the therapy of prolactin pituitary adenoma (micro- or macro prolactin);
- For men, the drug is used for hyperprolactinemia, which is manifested in decreased libido or impotence;
Off-label uses of the drug include the use of the pills as serotonin-specific reuptake inhibitor antidepressant. The drug is also believed by some people to have an effect allowing men to reduce the time for getting an erection between the intercourses.
Systematic analysis and continuing research also revealed that Generic Dostinex reduces the incidence of ovarian hyperstimulation without influencing pregnancy outcomes in women undergoing stimulated cycles of in vitro fertilization.
How does Generic Dostinex medication act?
The active substance of Generic Dostinex is Cabergoline which is a dopaminergic agent and ergoline derivative. It has a pronounced and long-lasting prolactin reduction effect. The effect is achieved through the blocking of prolactin secretion as a result of direct stimulation of D2 dopamine receptors in prolactin cells (lactotropes) of the pituitary gland. In the use of high dosages of the drug, a stimulating effect on the central nervous system is also observed.
Is there a difference between the brand-name medication and generic?
When you buy Generic Dostinex (Cabergoline) online from an online pharmacy like ours, who values its customers and sells only qualitative, properly tested and certified drugs, you can be sure that you will get the pills identical to the brand-name medication by the composition, effect, and safety. There is no reason to pay for the advertised brand name because generic medications are officially approved and even promoted by the World Health Organization.
How Dostinex (Cabergoline) should be used?
The medication is prescribed in different dosages for different purposes. For example, there is a different dosage and manner of intake between for the prevention of lactation after birth and suppression of milk production if you already started to breastfeed. Therefore, before you buy Generic Dostinex (Cabergoline) online, we strongly advise you to consult your doctor first. Nevertheless, we provide the general recommendations from the medication instruction for information purpose:
For the milk production suppression right after birth, a single dosage of Dostinex (Cabergoline) 1 mg should be used during the first day after labor.
For the suppression of lactation after giving birth but when you have already started to breastfeed, 0.25 mg should be taken every 12 hours during 2 days.For the therapy of hyperprolactinemia, the medication should be taken 1-2 times a week on the certain days. For example, every Monday if your doctor prescribes you to take the medication one time a week, or every Monday and Thursday if you need to take the pills 2 times a week. It is recommended to start from the low dosages of 0.25-0.5 mg one time per week. If required, the dosage can be gradually increased by 0.5 mg every month based on the tolerance to the medication and therapeutic response.
The average therapeutic dosage of Cabergoline is 1 mg per week. Usually, for the therapy of hyperprolactinemia, the maximum weekly dosage is 4.5 mg. If the necessary dosage is more than 2 mg a week, it should be divided into two intakes. Once the optimal dosage is chosen, it is recommended to check prolactin level in the blood once a month. Commonly, the normalization of prolactin level is observed in a half of month or a month of the therapy.
Whom the drug is contraindicated?
You should not buy Generic Dostinex (Cabergoline) if you have the severe liver impairment, late preeclampsia, allergy to ergot alkaloids, Cabergoline or other Dostinex components, history of postpartum psychosis.
Can Generic Cabergoline (Dostinex) be used during pregnancy?
The medication should not be used during pregnancy. Therefore, before you start the therapy, you should check if you are pregnant or not. Moreover, during one month after the therapy with Generic Cabergoline you need to use contraception to avoid pregnancy.
What side effects can the drug cause?
Usually, the drug is well tolerated. If Dostinex is prescribed to prevent or suppress lactation, it is often accompanied by vertigo, lowered blood pressure, insomnia, headache, nausea, and abdominal pain. These symptoms are mild and fade away quickly. If the drug is used for the treatment of hyperprolactinemia, vertigo, headache, nausea, indigestion, abdominal pain, constipation, fatigue, breast tenderness, mood fluctuations, and flashes can be observed. The symptoms are usually slightly or moderately expressed and fade away quickly. The most common side effects occur within the first 14 days of Dostinex use. In most cases, the adverse reactions can be eliminated with the dosage reduction.
Incidence of Dostinex (Cabergoline) adverse effects compared to placebo
Adverse Reaction
|
Cabergoline (n=168) 0.125 to 1 mg two times a week Number of patients (percent)
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Placebo (n=20)
Number of patients (percent)
|
Nausea
|
45 (27)
|
4 (20)
|
Constipation
|
16 (10)
|
0
|
Abdominal pain
|
9 (5)
|
1 (5)
|
Indigestion
|
4 (2)
|
0
|
Vomiting
|
4 (2)
|
0
|
Headache
|
43 (26)
|
5 (25)
|
Dizziness
|
25 (15)
|
1 (5)
|
Paresthesia
|
2 (1)
|
0
|
Vertigo
|
2 (1)
|
0
|
Asthenia
|
15 (9)
|
2 (10)
|
Fatigue
|
12 (7)
|
0
|
Hot flashes
|
2 (1)
|
1 (5)
|
Psychiatric Somnolence
|
9 (5)
|
1 (5)
|
Depression
|
5 (3)
|
1 (5)
|
Nervousness
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4 (2)
|
0
|
Postural hypotension
|
6 (4)
|
0
|
Reproductive - Female Breast pain
|
2 (1)
|
0
|
Dysmenorrhea
|
2 (1)
|
0
|
Abnormal vision
|
2 (1)
|
0
|
Interactions with other medications
It is not recommended to use the drug with dopamine antagonists (Butyrophenones, phenothiazines, metoclopramide, and thioxanthenes) because the drug stimulates dopamine receptors and the antagonists of dopamine can cause the ineffectiveness of Dostinex.
The drug also lowers the blood pressure; therefore, you should avoid using any other medications that have the same effect while using Generic Cabergoline (Dostinex).
Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.
Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.
For more answers see the FAQ section
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