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4RX Store > Medication List > Women`s Health drugs > Order Duphaston online

Women`s Health Medication (Duphaston)

Generic name:
Brand name:
The medication sold under the brand name Duphaston is based on Dydrogesterone. It is a medication used to prevent miscarriage, treat endometriosis, and other diseases of the female reproductive system. The medication acts on selective progestogen action on the uterine mucosa. Find out how to use it, what are the contraindications for use, and other useful information from the product description below.
Endometriosis, Infertility due to luteal insufficiency, Threatening miscarriage (with progesterone deficiency), Habitual miscarriage, Premenstrual syndrome, Irregular menstrual cycle, Dysmenorrhea, Uterine bleeding, Hormone replacement therapy
The medication helps normalize hormonal balance to prevent miscarriage and treat various reproductive system disorders
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Abbott - A promise for life
Diphaston, Dufaston, Duvaron, Dydrogesterona, Gestatron, Gynorest, Hydrogesterone, Isopregnenone, Prodel, Retrone, Terolut
Duphaston (Generic Dydrogesterone)
Actual product may differ in
appearance from image shown.

Order Generic Dydrogesterone Buy Duphaston 10mg


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  20 pills
$57.89 ($58.61)








  30 pills
$79.31 ($86.43)








  40 pills
$104.90 ($119.53)








  50 pills
$130.89 ($158.43)








  100 pills
$260.10 ($291.51)








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  Generic Medication guide:

What is the medication named Duphaston and when is it used?

The medication sold under different trade names, among which is Duphaston, is based on Dydrogesterone. It is a medication for oral administration with selective progestogen action on the uterine mucosa.

If your doctor prescribes you this drug, you can buy Duphaston at our online drugstore to save on the pills.

Short drug info
Trade names Duphaston, others
Other names Isopregnenone; Dehydroprogesterone; Didrogesteron; 6-Dehydroretroprogesterone; 9β,10α-Pregna-4,6-diene-3,20-dione; NSC-92336
Routes of administration By mouth
Drug class Progestin; Progestogen
Legal status In general: Rx (Prescription only)
Bioavailability 28%
Protein binding ? (probably to albumin)
Elimination half-life 5–6 days
Metabolism Hepatic: AKR1C1, AKR1C3, CYP3A4
Metabolites 20α-DHD (exclusively via AKR1C1 and AKRC13)
Elimination half-life Parent: 5–7 hours Metabolite: 14–17 hours
Excretion Urine

Chemical properties of Duphaston

Property Name Property Value
Molecular Weight 312.4 g/mol
XLogP3-AA 3.8
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 1
Exact Masss 312.20893 g/mol
Heavy Atom Count 23
Formal Charge 0
Complexity 628
Isotope Atom Count 0
Defined Atom Stereocenter Count 6
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Pharmacological properties

Duphaston is a hormonal drug that is prescribed to women with diseases of the reproductive system. Dydrogesterone is a selective progestogen that replaces some of the functions of progesterone, affects only the endometrium, the mucous membrane of the vagina and cervical canal. It does not inhibit ovulation, which makes fertilization possible for non-pregnant women.

When is Duphaston indicated to be used?

You can buy generic Duphaston for:

- Endometriosis;

- Infertility due to luteal insufficiency;

- Threatening miscarriage (with progesterone deficiency), habitual miscarriage;

- Premenstrual syndrome;

- Irregular menstrual cycle, dysmenorrhea;

- Uterine bleeding;

- Hormone replacement therapy.

Release form

Coated tablets of 10mg No. 14, No. 20 in blisters.

How is Duphaston used?

The drug is taken orally. Duration of use and dose can be adjusted individually by the doctor.

- Endometriosis: 1 tablet 2-3 times a day, from 5 to 25 days of the cycle.

- Infertility: 1 tablet per day from the 14th to the 25th day of the cycle, the duration of administration is 6 months (6 cycles), and also continue in the first months of pregnancy.

- Hormone replacement therapy in combination with estrogens, Duphaston is prescribed 1 tablet per day.


The use of the drug under the age of 18 is contraindicated.

Use during pregnancy or lactation

During pregnancy, the drug can be prescribed according to individual indications. When taking the drug, the active substance is excreted in breast milk. Therefore, it is not recommended to use during breastfeeding.

Special recommendations

- Before you buy Dydrogesterone for pathological bleeding, the cause of the bleeding should be excluded.

- In the first months of use, spotting or slight bleeding is possible. If the discharge is accompanied on an ongoing basis or occurs after the end of treatment, the cause should be established, a biopsy should also be done to exclude malignant neoplasm of the uterus.

If while taking the drug appears:

- Strong headache;

- Migraine;

- Increase in blood pressure;

- Venous thromboembolism or another symptom that interferes with the normal state is manifested. You need to consult your doctor immediately to adjust the dosage or discontinue the drug use.

- When taking the drug in the treatment of a threatened miscarriage, regular monitoring of the embryo is needed.

- Patients with a history of depression should be under constant medical supervision. If relapses occur, treatment should be discontinued.

Contraindications for Duphaston use

You should not buy generic Dydrogesterone and use it in:

- Individual intolerance to the drug of its components;

- Bleeding of not detected etiology;

- Violations of the liver function, chronic liver disease during treatment or earlier;

- In a planned abortion.

Side effects of Duphaston

When you order Duphaston and start using the drug, such side effects are possible:

- Migraine / headache, dizziness, drowsiness;

- Nausea, vomiting;

- Menstrual disorders and pain/sensitivity of the mammary glands;

- Neoplasms are possible (cysts, polyps);

- Rarely hemolytic anemia;

- Mental disorders, depressed mood;

- Skin rashes, itching are possible;

- Rarely the appearance of edema or weight gain.

Interaction with other drugs and other types of interaction

It is possible to accelerate the metabolism of Duphaston while using Phenobarbital, Rifampicin and reduce the effectiveness of the drug.

Incompatibility with other drugs is unknown.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Duphaston can affect the management of vehicles and work with other mechanisms, as may cause drowsiness or dizziness, especially during the first hours of administration. Therefore, use with caution when driving or working with machinery.


Duphaston is not a toxic drug. Symptoms that may occur are nausea, vomiting, dizziness. If you overdosed, induce vomiting and take activated carbon.

Where can you buy Duphaston?

To save on the therapy, you can order generic Duphaston from our online drugstore. We sell the drug without a prescription and also offer free shipping on all orders over $170. The shipping is international. We offer high-quality generic drugs that are identical to the branded ones but are priced cheaper.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section


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