What is Provera and when is it used?

Provera is one of the trademarks used to sell the medicinal substance Medroxyprogesterone. It is a steroid progestin used for various conditions in which hormonal regulation is required.

If you need to buy Provera, you can get a generic medication instead with the same composition but priced cheaper because it is less promoted as the brand of Pfizer.

The medication is a gestagen (progestogen), which has a long-lasting effect and does not have androgenic and estrogenic activity. It suppresses the secretion of pituitary gonadotropins (especially LH), as a result of which the maturation of follicles is prevented in women and prolonged anovulation is observed. Provera reduces vasomotor symptoms during menopause, inhibits secretory changes in the endometrium, increases the viscosity of cervical mucus, elevates the number of intermediate cells in the maturation index of the vaginal epithelium, and does not affect lactation.

In men, progestogen inhibits testosterone production. The manifestation of androgenic and anabolic effects is possible.

When taken for contraception, it reduces the risk of inflammatory diseases of the genital organs, vulvovaginal candidiasis. Most women with endometrial hyperplastic processes exhibit partial or complete regression.

In high doses, it has an antitumor effect in hormone-sensitive neoplasms. The antitumor effect is determined by the complex effect on the pituitary gland, estrogen receptors and the metabolism of steroid hormones at the tissue level.

In breast cancer, there is a correlation between the effectiveness of therapy and the concentration of estrogen and progesterone receptors in the tumor tissue.

When is Provera prescribed?

You can buy generic Provera if your doctor prescribes it to you for:

- Secondary amenorrhea,

- Dysfunctional uterine bleeding,

- Premenstrual syndrome,

- Vasomotor symptoms during menopause,

- Endometriosis,

- Diagnosis of primary and secondary amenorrhea,

- Prevention and treatment of osteoporosis in the postmenopausal period (in combination with estrogen and calcium preparations),

- Prevention of endometrial changes during replacement therapy estrogen in postmenopausal women.

- Contraception, especially in women of late reproductive age;

- Inoperable, recurrent and metastatic carcinomas of the endometrium and kidneys (additional palliative therapy),

- Hormone-dependent forms of recurrent breast cancer in postmenopausal women.

When is the use of generic Provera contraindicated?

- Hypersensitivity, - Pregnancy, - Tumors of the genital organs or mammary gland (except for cases of antitumor therapy),

- Bleeding from the genital tract of unknown origin,

- Lactation.

Use with caution:

- Thrombophlebitis, thromboembolism or stroke (increased risk of development or history),

- Liver failure,

- Hypercalcemia,

- Epilepsy,

- Migraine,

- Bronchial asthma,

- Heart or kidney failure,

- Diabetes mellitus,

- Depression.

How is Provera used?

The medication comes in different formulations. On this webpage you can find oral tablets. Make sure to buy Medroxyprogesterone which is appointed by your doctor.

- Suppression of ovulation (contraception): the recommended dose is 150 mg of Provera every 3 months (deep IM injection). To ensure that the patient is not pregnant at the time of the initial use of the drug, it is recommended that the first injection be given within the first 5 days after the start of the next menstruation or earlier 6 weeks after delivery.

- Dysfunctional (anovulatory) uterine bleeding: by mouth, 5–10 mg / day for 10 days. During this time, bleeding gradually stops. 3-7 days after withdrawal of Provera, progestin “withdrawal” bleeding begins. After this, therapy can be repeated starting from day 16 of the cycle for 2-3 cycles.

- Endometriosis: the medication is administered intramuscular; the recommended dose of Provera is 50 mg once a week or 100 mg once every 2 weeks for at least 6 months. Due to the long-term effect, the restoration of the menstrual cycle after such therapy may occur after some time. In addition to the i/m introduction, it is possible to treat endometriosis by ingestion, 10 mg 3 times a day for 90 days, starting from the first day of the cycle.

- Differential diagnosis of primary and secondary amenorrhea: the drug is prescribed at 5-10 mg/day for 10 days. For the prevention of endometrial hyperplasia with estrogen therapy in menopause: 5-10 mg/ day for at least 10 days, starting from day 16 of a 25-day course of estrogen treatment.

- Complementary and palliative treatment of recurrent and metastatic endometrial cancer or kidney cancer: 200-600 mg / day, by mouth; with the i/m introduction of the depot form, 0.5-1 g/week is prescribed, the maintenance dose is 500 mg/week.

- Breast cancer: inside, 400-1200 mg / day; in i/m - 500 mg/day for 28 days, then switch to a maintenance dose - 500 mg once every 2 weeks. Treatment results may appear after 8-10 weeks.

- For prevention and treatment of post-menopausal osteoporosis - from 12-15 to 25 days of the month, 5-10 mg once a day.

What adverse reactions can generic Provera cause?

When you buy generic Medroxyprogesterone be ready that you can develop certain negative effects:

- From the nervous system: headache, dizziness, irritability, insomnia, drowsiness, fatigue, depression.

- From the digestive system: nausea, pain and discomfort in the abdomen.

- Hematopoietic organs and hemostasis: thromboembolic disorders (thrombophlebitis, cerebrovascular disorders, thromboembolism of small branches of the pulmonary artery, renal thrombosis).

- Allergic reactions: urticaria, pruritus, rash, anaphylactoid reactions.

- On the part of the endocrine system: increased sensitivity of the nipples of the mammary glands, galactorrhea, cervical erosion, dysmenorrhea, “spotting” discharge, decreased glucose tolerance. When used in a dose of more than 500 mg/day - acne, hirsutism, weight change, moon-shaped face.

- Other: hyperthermia, alopecia. - Local reactions: at the injection site - pain, residual compaction, discoloration of the skin.

ABSOLUTE RISK SEEN IN THE ESTROGEN PLUS PROGESTIN SUBSTUDY OF WHI AT AN AVERAGE OF 5.6 YEARS (Absolute Risk per 10,000 Women-Years)

Special instructions

- When conducting a histopathological examination of certain organs and tissues, it is necessary to warn the histologist about previous treatment with the medication.

- During treatment, changes during the following studies are possible: determination of the concentration of gonadotropins, gestagen, cortisol, testosterone (in men), estrogen (in women) in plasma; determination of the concentration of pregnanediol in the urine; sugar loading test; conducting a test with metapiron.

- If there is a history of depressive conditions, careful monitoring is necessary during the treatment period.

- Before starting therapy, erosion of the cervix should be sanitized. With continued erosion - careful medical supervision is required. - With dysfunctional uterine bleeding, uterine cancer and other organic lesions are necessarily excluded.

- Suspicion of developing hypocoagulation requires immediate withdrawal. Interaction of Provera and generics Aminoglutethimide reduces plasma concentration and decreases effectiveness.

Where can you buy Provera?

You can get the medication at your local drugstores or order generic Provera from our med store and get the same medication several times cheaper just because it is not a promoted brand.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section