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4RX Store > Medication List > Other drugs > Order Aromasin online

Other Medication (Aromasin)

 
Generic name:
Aromasin
Brand name:
Exemestane
Description:
Aromasin is a medication based on Exemestane. It is an inhibitor of aromatase, a conversing substance that transforms androgens into estrogen in postmenopause. The medication lowers levels of estrogen by 90% which is beneficial for the therapy of estrogen-dependent breast cancer. Read the full guide to know how the drug is used, about its side effects, and so on.
Indications:
Treatment of hormone-dependent breast cancer
Benefits:
The medication suppresses the production of estrogens and slows down hormone-dependent breast tumors growth
Synonyms:
Exemestance
 
   
Aromasin (Generic Exemestane)
 
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Order Generic Exemestane Buy Aromasin 25mg

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  Generic Medication guide:

What is Aromasin and when is it used?

Aromasin is one of the trade names registered for the medication based on Exemestane. This particular brand is owned and promoted by Pfizer but if you need to buy Aromasin you can as well opt for a generic version of the medication based on Exemestane.

Short drug info
Trade names Aromasin, others
Other names FCE-24304
Pregnancy category US: D (Evidence of risk)
Drug class Aromatase inhibitor; Antiestrogen
Legal status US: Rx-only
Bioavailability ~60%
Protein binding 90%
Metabolism Liver (CYP3A4, aldo-keto reductase)
Elimination half-life 24 hours
Duration of action 4–5 days
Excretion Urine and feces ~ 1:1 (mainly metabolites)

The active agent of the described medication is n irreversible steroidal inhibitor of aromatase similar to the naturally produced androstenedione. Aromatase is the substance that transforms androgens to estrogens and is this conversion is the major source of estrogens in postmenopausal women. When the aromatase is blocked by Aromasin, the level of total estrogen is substantially reduced which is beneficial for the treatment of hormone-dependent cancers of breasts in postmenopausal women.

In users, the medication starts to lower the level of estrogen when taken even in the smallest dosage of 5 mg a day. But the optimal lowering up to 90% is achieved in the use of the dosages in the range from 10 mg to 25 mg a day.

After a dosage is taken, the medication is quickly absorbed in the digestive tract. After a single dosage use, the maximum level of the medication in the plasma is achieved in 2 hours. The intake of the medication with food increases the amount of it that is active within the body.

When is the use of Aromasin indicated?

You can be prescribed to buy generic Aromasin for:

- Therapy of early stage hormone-dependent mammary gland cancer in postmenopause after two to three-year therapy with Tamoxifen.

- Treatment of metastasized breast cancer in women in natural or induced postmenopause with the progression of the disease during the use of antiestrogens. Please do not use the medication if it is not prescribed by your doctor.

When is the use of Aromasin contraindicated?

The medication is prohibited to be used in increased sensitivity to its components and:

- Premenopausal endocrine status;

- Pregnancy and lactation;

- Childhood.

With caution - impaired liver or kidney function.

How is Aromasin used?

When you buy Exemestane, your doctor must instruct you how to use the medication. If not otherwised prescribed by your doctor, you can use it as described below.

The pills are taken once a day in the dosage of 25 mg (one pill) preferably after a meal. Do not crush or chew the pill.

- In individuals with early breast cancer, the therapy should be continued till the end of 5-year sequential adjuvant hormone therapy or until relapse of the tumor.

- In metastasized breast cancer the treatment with the medication is continued until the progression of the tumor is observed. Dosage adjustments In kidney or liver failure dosage adjustments are not required.

Overdose of Aromasin

There is no data on the medication overdose with the lethal outcome or severe adverse effects. The tested dosages of 800 mg per day were in general well tolerated.

If in an overdose adverse effects enhance, treatment implies only the control over the symptoms and their elimination.

What adverse effects can Aromasin and its generics cause?

In general, you can buy generic Exemestane and use it without fear as it is usually well tolerated and if it causes adverse effects than only mild ones that pass away quickly.

Below you can find the tables with the incidence of Aromasin adverse effects incidence compared to placebo and Tamoxifen.

Incidence of Aromasin treatment-developed adverse reactions compared to placebo

Adverse Reaction
Exemestane
N=73 (% incidence)
Placebo
N=73 (% incidence)
Hot flushes
32.9
24.7
Arthralgia
28.8
28.8
Increased sweating
17.8
20.6
Alopecia
15.1
4.1
Raised arterial tension
15.1
6.9
Insomnia
13.7
15.1
Nausea
12.3
16.4
Fatigue
11.0
19.2
Abdominal pain
11.0
13.7
Depression
9.6
6.9
Diarrhea
9.6
1.4
Dizziness
9.6
9.6
Dermatitis
8.2
1.4
Headache
6.9
4.1
Muscle pain
5.5
4.1
Swelling
5.5
6.9

Incidence (%) of Aromasin adverse reactions occurring in (≥5%) of patients compared to Tamoxifen

Adverse Reaction
AROMASIN 25 mg daily
(N=2252) % of patients
Tamoxifen 20 mg daily
(N=2280) % of patients
Visual impairments
5.0
3.8
Nausea
8.5
8.7
Fatigue
16.1
14.7
Arthralgia
14.6
8.6
Pain in extremities
9.0
6.4
Back pain
8.6
7.2
Osteoarthritis
5.9
4.5
Headache
13.1
10.8
Dizziness
9.7
8.4
Insomnia
12.4
8.9
Depression
6.2
5.6
Increased sweating
11.8
10.4
Hot flushes
21.2
19.9
Raised arterial tension
9.8
8.4

Can Aromasin be used with other medications?

When you order Aromasin, make sure to check with your doctor that other medicines that you may use are compatible with this drug:

- Estrogen-containing medicines estrogens neutralize the pharmacological effect of Exemestane so they must not be used together.

- The medication is metabolized under the effect of P450 (CYP) 3A4 enzyme and aldoketoreductase and doesn’t inhibit any of the main iso-enzymes that participate in the metabolism of other medicines.

- Ketoconazole inhibits CYP3A4 but it doesn’t affect the metabolism of Aromasin so the medicines can be combined.

- There is an interaction with Rifampicin which is a potent inducer of CYP3A4 but it doesn’t influence the effect of Aromasin so the medicines can be sued together in regular dosages.

Special recommendations for Aromasin use

- Before you order generic Aromasin, your doctor should assess levels of 25-hydroxyvitamin D in the body, as severe deficiency is often associated with early stages of breast cancer. Vitamin D-deficient women need to receive extra vitamin D.

- Considering the mechanism of the medication’s effect, it should not be used for women in premenopause. If there are doubts about the status, it should be established by evaluating the levels of LH, FSH and estradiol.

- As the medication substantially lowers the level of estrogens, a drop in bone mineral density can be expected. Thus women with osteoporosis or the risk of its development should be examined to identify the bone mineral density parameters using densitometry at the beginning of treatment. Patients taking Exemestane should be observed, and if necessary, start therapy for osteoporosis.

- Women with severe kidney or liver failure do not need dosage adjustments.

- The medication renders a toxic effect on the fetus so it must not be used during pregnancy and lactation.

- If the medication is prescribed for women of childbearing age, women in menopause or in early postmenopause, a doctor should consult their patient and inform about the need of reliable contraception.

Can the medication affect reaction time and interfere with driving?

Sometimes the medication can cause sleepiness, dizziness, fatigue, and other symptoms that can interfere with reaction speed so it is advised to refrain from driving or operating any mechanisms at least during the first days or weeks of Aromasin use till the fading of these adverse effects.

Where can you buy Aromasin?

The medication is sold at the regular drugstores with Rx only and mostly in the branded version. You can significantly save if you order generic Exemestane which is identical to the branded drug but costs cheaper at our online drugstore. Besides, we sell the medication without Rx so you don’t need to spend money and go to your doctor for refill Rx. However, we highly encourage you to get the drug and start using it only if your doctor had initially prescribed it to you.

Aromasin shipping

Our med store ships all products internationally via standard and express shipping. If you want to order pills for several months ahead, you can order for $170 or more and enjoy free standard shipping.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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