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4RX Store > Medication List > Other drugs > Order Mirapex online

Other Medication (Mirapex)

 
Generic name:
Mirapex
Brand name:
Pramipexol
Description:
Mirapex is one of the trademarks of Pramipexol, an antiparkinsonian medication also used for restless legs syndrome. The active agent of the medication is a powerful antagonist, i.e. stimulator of dopamine receptors. It helps with the relieving of movement impairments associated with Parkinsonís disease and Restless legs syndrome and also helps with the symptoms of accompanying depression. It can be used alone or with Levodopa for a more effective treatment.
Indications:
Parkinsonís disease, Restless legs syndrome
Benefits:
The medication helps relieving movement symptoms and depressive state in treated diseases
Manufacture:
Sun Pharma
Sun Pharma
Synonyms:
Furfuryl Acetate
 
   
Mirapex (Generic Pramipexol)
 
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Order Generic Pramipexol Buy Mirapex 1mg

 

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  Generic Medication guide:

What is the medication marketed as Mirapex?

Mirapex is a trademark owned by the German pharmaceutical company named Boehringer Ingelheim. It is an antiparkinsonian medication based on Pramipexole which is a dopamine agonist. If you need to use it, you can buy Mirapex from our online drugstore in a form of a generic medication, i.e. the same formulation made by another company. We offer you the medication made y Sun Pharma, a leading manufacturer of generics sold all over the world.

Short drug info
Trade names Mirapex, Mirapexin, Sifrol
Routes of administration Oral
Pregnancy category

AU: B3

US: C (Risk not ruled out)

Legal status In general: Rx (Prescription only)
Bioavailability >90%
Protein binding 15%
Elimination half-life 8–12 hours
Excretion Urine (90%), Feces (2%)

Mirapex and its generics are prescribed for:

- Treatment of Parkinson’s disease in adults as monotherapy or along with Levodopa, fro the early stages of the disease until the later stages, when the effect of Levodopa decreases or becomes unstable and there are fluctuations in the therapeutic effect (on-off phenomenon).

- Treatment of restless legs syndrome from moderate to severe stage in adults.

The formulation is a dopamine agonist (chemical compound, which, when interacting with the receptor, changes its state, leading to a biological response) with the high selectivity. It helps with the minimization of Parkinson’s disease movement impairments by stimulating the receptors of the corpus striatum in the brain. Besides improving the movement impairment, Pramipexol also helps with the minimization of neuropsychological impairments, including depression and cognitive functions violations. The medication also slows down the degenerative processes in the dopaminergic neurons.

When is the use of Mirapex contraindicated?

You should not buy generic Mirapex and use it if you are intolerant of the medication’s components which can be manifested in severe adverse effects or allergy associated with the pills use.

How is Mirapex used?

The dosage should be chosen by a doctor individually. In this guide we provide general recommendations.

The pills can be taken without regard to meals.

The daily dosage for Parkinson’s disease is taken in three equal-dose intakes. The treatment is started with the minimal dosage which is then gradually increased. The scheme for raising the dosage is illustrated in the table below. The raise of the dose is feasible if the use of the formulation is well tolerated.

Scheme of Mirapex (Pramipexol) dosage raise by weeks

Week
Dose, mg
Total daily dosage, mg
First
3×0125
0,375
Second
3×0,25
0,75
Third
3×0,5
1,5

If needed, the dosage can be further raised by 0,75 mg every week. The maximum dosage per day is 4.5 mg. However, in the use of the dosages higher than 1,5 mg a day drowsiness is more likely to develop.

The dose should be chosen and adjusted individually based on the response of a patient, occurrence of adverse reactions, and so on. Overall, the optimal effect is observed in the use of 1,5 mg a day. However, in progressing Parkinson’s diseases, higher dosages may be recommended if there is a plan to lower the dosage of Levodopa.

If there is a need of therapy ending, it should be done by the gradual reduction of the dosage as an abrupt withdrawal can cause neuroleptic malignant syndrome. The dose of Pramipexole should be reduced according to the scheme by 0.75 mg to a daily dose of 0.75 mg. After this, the dose should be reduced to 0.375 mg/day.

Restless leg syndrome treatment is started with the dosage of 0,125 mg a day two to three hours before sleep. If there is a need of a more potent effect and the medication is well tolerated, the dosage can be raised every 4-7 days till the maximum 0,75 mg a day based on the scheme provided in the table below.

Scheme of Mirapex (Pramipexol) dosage raise by weeks in kidney failure

Stages of dosage raise
Single evening dosage/daily dosage, mg
1 0,125
2 0,25
3 0,5
4 0,75

The ending of the therapy for restless leg syndrome can be made with a complete drug withdrawal without the lowering of the dosage because the dosages used are low.

The condition of a patient must be assessed after three months of uninterrupted use to evaluate the necessity of further therapy. If the treatment is interrupted for several days, it should be restarted with the low dosage (previously used before the last raise) which is then gradually increased.

Dosages for individuals with kidney failure

The washing out of the medication from the body depends on kidney function. Thus, there should be made certain adjustments. - In creatinine clearance more than 50 ml per minute, dosage lowering is not needed.

- In creatinine clearance 20-50 ml per minute the initial daily dosage is taken in two intakes starting from 0,125 mg (the daily dose is 0,250 mg). The highest daily dose is 2,25 mg.

- In creatinine clearance less than 20 ml per minute, the daily dosage is taken in one intake starting from 0,125 mg a day. The highest daily dose is 1,5 mg. If during the therapy the kidney function gets worse, the daily dosage of Mirapex is lowered by the percent at which creatinine clearance dropped. For instance, if creatinine clearance is lowered by 20%, the daily dosage of the formulation is lowered also by 20%. The daily dosage can be taken into two intakes if creatinine clearance is between 20 and 50 ml per minute. It should be taken in one intake in cc less than 20 ml per minute.

Dosages for patients with liver failure

There is no need for dosage adjustments in patients with liver failure because 90% of the medication is eliminated through the kidneys.

What adverse effects can Mirapex cause?

When you buy Pramipexol, you should know that its use can be associated with certain negative effects. Their incidence compared to placebo can be found in the tables below.

Adverse-Reactions in Pooled Double-Blind, Placebo-Controlled Trials with MIRAPEX in Early Parkinson's Disease

Body System/Adverse Reaction
MIRAPEX (N=388) %
Placebo (N=235) %
Diziness
25
24
Somnolence
22
9
Insomnia
17
12
Hallucinations
9
3
Confusion
4
1
Amnesia
4
2
Hypesthesia
3
1
Dystonia
2
1
Akathisia
2
0
Thinking abnormalities
2
0
Decreased libido
1
0
Myoclonus
1
0
Nausea
28
18
Constipation
14
6
Anorexia
4
2
Dysphagia
2
0
Asthenia
14
12
General edema
5
3
Malaise
2
1
Reaction unevaluable
2
1
Fever
1
0
Peripheral edema
5
4
Decreased weight
2
0
Vision abnormalities
3
0
Impotence
1
0

Adverse-Reactions in Pooled Double-Blind, Placebo-Controlled Trials with MIRAPEX in Restless Legs Syndrome

Body System/Adverse Reaction
MIRAPEX 0.125 - 0.75 mg/day
(N=575) %
Placebo
(N=223) %
Nausea
16
5
Constipation
4
1
Diarrhea
3
1
Dry mouth
3
1
Headache
16
15
Somnolence
6
3
Fatigue
9
7
Influenza
3
1

Can Mirapex be used with other medicines?

- The medication can be used together with Levodopa but the dosages of the latter should be lowered with the raised of Mirapex dosages.

- The medication must not be combined with antipsychotics as the lower the drug’s effect.

- Mirapex should not be used with alcohol or sedative medications as they enhance its adverse reactions such as sleepiness and sleepiness attacks.

- The elimination of the medication from the body is influenced by the drugs that suppress the active kidney elimination or are eliminated through the kidneys extensively. These medicines include cimetidine, amantadine, mexiletine, zidovudine, cisplatin, quinine and procainamide. If they are prescribed to be used at the same time with Pramipexol, the dosage of the latter should be lowered.

Special recommendations for Mirapex use

Before you buy generic Pramipexol, get acquainted with precautions:

- The medication must be used in lowered dosages in kidney dysfunctions. In severe kidney dysfunction, the minimal dosages are used and control over creatinine clearance is required so that the dosage could be lowered respectively to the lowering of creatinine clearance.

- Mirapex and its generics can cause hallucinations especially in senior patients.

- Dyskinesia (sudden involuntary movements in various muscle groups) can develop when the Mirapex is used with Levodopa and the dosages of Mirapex are raised. In this case, the dosage of Levodopa should be lowered.

- Pramipexol can cause drowsiness and sleepiness attacks especially in Parkinson’s disease. They can occur without any symptoms and result in sudden falling asleep during the day. Thus, when the drug is used, it is highly advised to refrain from driving vehicles or operating any heavy machinery. In the occurrence of sleepiness or sleepiness attacks, you should inform your doctor and a possible reduction of the dosage or withdrawal of the medication may be needed. You should be particularly careful if you use the medication with any sedatives (claiming drugs) or alcohol.

- The medication can cause disorders of control over motives. Careful monitoring is needed regarding the development of impulse control disorders. Users of the drug and caregivers should be aware that dopamine agonists can induce behavioral symptoms of impulse control disorder, including a pathological craving for gambling, increased libido, compulsive waste or overeating, and so on. With the development of such symptoms, it is necessary to consider the possibility of reducing the dose /gradual discontinuation of the formulation use.

- The use of Mirapex or a generic version of the medication can cause mania or delirium. Patients and their caregivers must be informed about such dangers and they should inform a doctor in the occurrence of the first symptoms. In their occurrence, it is recommended to lower the dosage or even completely stop using the medication (the withdrawal is made with the gradual reduction of the dosage).

- Individuals with mental disorders should receive dopamine agonists only if their doctors believe that the expected benefit is greater than the potential risk. The formulation should not be combined with antipsychotics.

- Individuals with vision impairment who use the medication should undergo vision examinations regularly.

- The medication must be cautiously used by people with severe cardiovascular diseases. They should daily control their blood tension especially at the start of the therapy. The medication can lower arterial tension and cause postural hypotension, i.e. a sharp drop of tension when standing up resulting in nearly fainting. - The use of the formulation must not be stopped abruptly. In case of the high dosages use and then an abrupt discontinuation, neuroleptic malignant syndrome can develop.

- The use of the medication for restless leg syndrome sometimes can cause the enhancement of the symptoms.

- The medication can be used during pregnancy if the expected benefit is greater than the risk to the fetus. It should not be used by breastfeeding women.

Where can you buy Mirapex?

If you have a prescription, you can get the medication at any drugstore. But if you wish to get it cheaper, you should instead opt for a generic version. We offer you to order generic Mirapex at a price lower than the branded drug. It is the same medication made by another pharmaceutical company named Sun Pharma and priced cheaper. You can also enjoy free shipping on orders over $170.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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