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4RX Store > Medication List > Other drugs > Order Persantine online

Other Medication (Persantine)

 
Generic name:
Persantine
Brand name:
Dipyridamole
Description:
Persantine is a branded medication based on Dipyridamole. It is a medication that helps with the prevention and treatment of blood clots which can lead to severe cardiovascular events up to a sudden death. The medication is appointed for different conditions such as prevention and treatment of arterial and venous thrombosis, brain ischemia, treatment of chronic obliterating diseases of the vessels of the lower extremities, especially in the presence of risk factors (arterial hypertension, smoking), prevention of placental insufficiency in complicated pregnancy, and others. Find out how it is used and what adverse effects the medication can cause from the guide below.
Indications:
Prevention and treatment of arterial and venous thrombosis and their complications, Cerebrovascular accident of ischemic type, Violation of microcirculation, Prevention of occlusion of stents and coronary artery bypass grafts, Treatment of Encephalopathy, Treatment of chronic obliterating diseases of the vessels of the lower extremities, Primary and secondary prevention of coronary heart disease, Prevention of placental insufficiency in complicated pregnancy
Benefits:
The medication helps preventing formation of blood clots and improves blood circulation in a number of conditions
Manufacture:
German Remedies
German Remedies
Synonyms:
Aggrenox, Cardioflux, Cardoxil, Coribon, Coroxin, Dipyridan, Gulliostin, Kurantil, Natyl, Permiltin, Piroan, Protangix, Stenocardil
 
   
Persantine (Generic Dipyridamole)
 
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Order Generic Dipyridamole Buy Persantine 25mg

 

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1
 
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  $0.22

 

 

 

 

 

 

 

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  Generic Medication guide:

What is the medication sold under the name Persantine?

Persantine is the brand of the medication owned by Boehringer Ingelheim, a german pharmaceutical company. Its active ingredient is Dipyridamole, an antithrombotic and antiplatelet agent used for different conditions in which the formation of blood clots occurs. These medicines are also called blood thinners. If your doctor prescribes you this drug, you can buy Persantine made by another manufacturer to get the same effect but cheaper. The medication with the same composition but made by another company is called generic Persantine and can be found at our online drugstore.

Short drug info
Trade names Persantine, others
Routes of administration By mouth, intravenously
Pregnancy category B (use is possible if the benefits are greater than the risks)
Legal status

UK: POM (Prescription only)

US: Rx-only

Bioavailability 37–66%
Metabolism Liver (glucuronidation)
Protein binding ~99%
Elimination half-life α phase: 40 min, β phase: 10 hours
Excretion Biliary (95%), urine (negligible)

Dipyridamole dilates the coronary vessels, increases the volumetric rate of coronary blood flow, improves the supply of myocardium with oxygen, and increases its resistance to hypoxia (low level of oxygen). It contributes to the improvement of blood circulation in the vasculature in case of violations of such in the main coronary vessels; reduces total peripheral vascular resistance, slightly reduces systemic blood pressure, improves cerebral circulation. The drug inhibits platelet aggregation and prevents thrombosis. This effect is due to stimulation of prostacyclin synthesis and inhibition of thromboxane biosynthesis. With an increase in the synthesis of prostacyclin in the vascular wall, the effect of the medication on the metabolism of arachidonic acid is associated. The anti-aggregation activity of Dipyridamole is similar to that of acetylsalicylic acid.

Indications for Persantine and its generics use:

You can buy generic Persantine for:

- Prevention and treatment of arterial and venous thrombosis and their complications (in particular, prevention of thromboembolism after surgery for prosthetic heart valves);

- Cerebrovascular accident of ischemic type;

- Violation of microcirculation (as part of complex therapy).

- Prevention of occlusion of stents and coronary artery bypass grafts (in combination with acetylsalicylic acid);

- Treatment of Encephalopathy;

- Treatment of microcirculatory disorders of any genesis (as part of complex therapy);

- Treatment of chronic obliterating diseases of the vessels of the lower extremities, especially in the presence of risk factors (arterial hypertension, smoking);

- Primary and secondary prevention of coronary heart disease, especially with intolerance to acetylsalicylic acid;

- Prevention of placental insufficiency in complicated pregnancy.

There are also other conditions for which the medication is used according to a doctor’s recommendations. You should also know that there are different medications for the same conditions and only a doctor can choose the right medication for you.

When is the use of Persantine contraindicated?

You should not buy Dipyridamole in case of:

- Hypersensitivity to Dipyridamole or to other components of the formulation;

- Acute myocardial infarction;

- Unstable angina pectoris;

- Decompensated heart failure;

- Severe heart rhythm disturbances;

- Severe arterial hypotension (systolic pressure below 90 mm Hg. Art.);

- Collapse;

- Hemorrhagic diathesis, diseases with a risk of bleeding (for example, peptic ulcer of the stomach and duodenum);

- Severe renal or hepatic insufficiency;

- Common stenotic atherosclerosis of the coronary arteries;

- Subaortic aortic stenosis;

- Bronchial asthma, obstructive pulmonary disease.

- Liver failure;

The medication is not recommended for children and adolescents under 12 years of age (safety and efficacy not determined).

Pregnancy and lactation

During pregnancy and breastfeeding, it is possible to use the medication if the intended benefit for the mother outweighs the potential risk to the fetus and the baby (passes into breast milk).

How is Persantine used?

Here you can find the general recommendations but we highly encourage you to follow your doctor’s instructions when you buy generic Dipyridamole (the same recommendations as for the branded medication use).

The pills are taken orally one hour before a meal. They should not be crushed or chewed as it influences the medication’s efficacy. The pill should be swallowed with sufficient amount of water or milk to lower the likelihood of adverse effects from the digestive tract.

The recommended daily dosage for adults and kids older than 12 years is 75-225 mg. The daily dosage is split into three equal intakes. In severe cases the dosage can be raised to 600 mg a day.

The duration of the course depends on the type and severity of the diseases. It usually is from several weeks to several months.

Overdose of Persantine

An overdose causes excessive dilation of the blood vessels and the drop of arterial tension. It can also cause increased sweating, dizziness, headache, anxiety and irritability, heart ache, rapid heartbeat, flushing, weakness, reddening of the face, and other symptoms. Treatment implies vomiting, gastric lavage, intake of sorbents, and therapy to reduce the symptoms. In case of heartache (angina attack), nitroglycerin is used.

What adverse effects can Persantine cause?

When you order Persantine, be ready that it can cause certain negative effects such as:

- Immune system: hypersensitivity reactions, including pruritus, skin rashes, urticaria, bronchospasm, angioedema.

- Nervous system: headache and dizziness, weakness, fainting, tremor.

- Cardiovascular system: chest pain, palpitations, exacerbation of symptoms of coronary heart disease, such as angina pectoris, arrhythmia (rapid or slow heartbeat), myocardial infarction, hypotension, sensation of fever, especially in people taking vasodilators, hyperemia of the skin of the face (hot flashes).

- Digestive tract: heartburn, burping, pain in the stomach region, nausea, vomiting, diarrhea.

- Hepatobiliary system: increased levels of liver enzymes;

- Other: myalgia, arthritis, increased bleeding during or after surgery, bleeding, thrombocytopenia, changes in the functional properties of platelets.

Incidence Persantine of adverse effects compared to placebo 

Adverse Reaction
PERSANTINE Tablets
Number of patients=147
Placebo
Number of patients=170
Dizziness
13.6%
8.2%
Abdominal distress
6.1%
3.5%
Headache
2.3%
0.0%
Rash
2.3%
1.1%

Can Persantine be used with other medicines?

When you order generic Persantine, check with your healthcare provider that you don’t take any medicines that are incompatible with it:

- The medication inhibits the reuptake of Adenosine, elevates its plasma levels and cardiovascular effects which has a significant risk of toxicity. The doses of Adenosine should be corrected if the medicines are used together.

- Persantine can lower the effect of Fludarabine.

- Coumarin-type anticoagulants, acetylsalicylic acid, heparin, clopidogrel, as well as beta-lactam antibiotics (penicillins, cephalosporins), tetracyclines, chloramphenicol – the medication enhances their anticoagulant and antiplatelet effect. The combination of Persantine (Dipyridamole) and coumarin anticoagulants or heparin does not change prothrombin time but may increase the risk of serious bleeding. The combination of Persantine (Dipyridamole) with aspirin does not increase the frequency of bleeding. There is an increased risk of bleeding when using Clopidogrel with Dipyridamole. When using the drug with acetylsalicylic acid or anticoagulants, information about the risks and incompatibilities of these medicines should be considered.

- The blood thinning effect of Phenindione is enhanced by Persantine (Dipyridamole).

- Dipyridamole can counteract the anticholinesterase effects of cholinesterase inhibitors, which can cause exacerbation of myasthenia gravis.

- Dipyridamole has some antimuscarinic effect. Additive antimuscarinic effects may develop, both peripheral and central, with the simultaneous use of two or more drugs with antimuscarinic properties.

- The medication enhances the effect of blood tension lowering medicines so their doses should be adjusted.

- The effect of the medication can be lowered by the use of antacids, sorbents, and enveloping medicines.

- Xanthine derivatives (caffeine, theophylline, aminophylline), products containing caffeine: weakening of the coronary expansion effect of dipyridamole, reducing its effectiveness.

- Digoxin: a slight increase in Digoxin absorption is possible.

Special recommendations for Persantine use

The medication should be used with caution in patients with:

- Arterial hypotension (low blood pressure);

- Severe pathology of the coronary arteries (for example, recent myocardial infarction, heart failure)

- chest pain may increase due to the vasodilation effect; the appointment of large doses of the drug can cause a decrease in blood supply to ischemic myocardial sites;

- Myasthenia gravis (risk of exacerbation) - dose adjustment of Dipyridamole may be required;

- The simultaneous use of drugs that increase the risk of bleeding.

- Oral administration of Dipyridamole should be discontinued 24 hours before an ECG test with dosed physical activity using intravenous Dipyridamole (stress testing).

- The use of Dipyridamole can lead to an exacerbation of migraine.

- The use of high doses of Dipyridamole can lead to an increase in the level of liver enzymes in the blood plasma and liver failure. Cases of the inclusion of unconjugated Dipyridamole in gallstones (up to 70% of the dry mass of calculus) in elderly patients with signs of cholangitis when taking the medication for several years have been reported.

- There are no data on the use of the drug in elderly patients with hepatic or renal failure, therefore, in these cases it should be used with caution. - During treatment, patients should refrain from the frequent use of strong coffee or tea.

- The medication should not be used in patients with lactase deficiency, galactosemia, glucose-galactose malabsorption syndrome (the pills contain lactose).

Where can you buy Persantine?

You can order generic Persantine from our online drugstore to save on the cost per pill as we offer high-quality generics identical to the branded drugs but priced cheaper. Besides, you can order pills for months ahead and spare yourself from the need to go to a doctor for a refill prescription.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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