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4RX Store > Medication List > Other drugs > Order Uprima online

Other Medication (Uprima)

 
Generic name:
Uprima
Brand name:
Apomorphine
Description:
Uprima is a medication based on Apomorphine which is a dopaminergic agonist and a central initiator of erection. It helps achieving a stable erection and maintaining it throughout the entire sexual intercourse. The same substance is also used for Parkinsonís disease but in different formulation. To know how to use Apomorphine for erection enhancement in erectile dysfunction, what adverse effects it can cause, and other useful information, read our guide.
Indications:
Erectile dysfunction, Impotence, Parkinsonís disease
Benefits:
The medication helps to obtain and maintain stable erection in erectile dysfunction
Synonyms:
Apokyn, Ixense, Zyprima
 
   
Uprima (Generic Apomorphine)
 
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Order Generic Apomorphine Buy Uprima 2mg

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  Generic Medication guide:

What is the medication sold under the name Uprima?

Uprima is one of the commercial names for the active substance Apomorphine. The medication is a dopaminergic agonist related to D1 and D2 receptors in parts of the brain involved in mediating an erection. The use of the medication in low dosages ensures an achievement of erection in erectile dysfunction. Higher dosages are used to induce vomiting in intoxication when gastric lavage is unsuitable.

You can buy Uprima sublingual tablets for erection achievement and enhancement if you have trouble with it but make sure to stick to the instructions provided below.

Short drug info
Trade names Apokyn, Uprima, and others
Routes of administration sublingually
Use during pregnancy

AU: B3

US: C (Risk not ruled out)

Legal status

AU: S4 (Prescription only)

CA: Rx-only

UK: POM (Prescription only)

US: Rx-only In general:

Rx (Prescription only)

Bioavailability 100% following injection
Protein binding ~50%
Metabolism Hepatic, phase II
Onset of action 10–20 min
Elimination half-life 40 minutes
Duration of action 60–90 min
Excretion Hepatic

Apomorphine acts as a central initiator of erection and strengthens pro-erectile stimuli. The erectogenic effect of Apomorphine is due to an improvement in the functioning of the central nervous signal system, which is responsible for vascular reactions in the cavernous tissues of the penis responsible for its filling in with blood, enlargement in size and strong erection.

The medication is quickly absorbed when taken sublingually and is found in the blood plasma in just 10 minutes. The maximum level of the drug in the blood is achieved in 40-60 minutes. The major part of the medication is eliminated with urine, and the remaining share in feces.

When are Uprima sublingual tablets indicated to be used?

You can buy generic Uprima if you suffer from erectile dysfunction of any cause and do not have any contraindications for its use.

The tablets are effective for erectile dysfunction manifested in inability to achieve erection and if an achieved erection can be maintained long enough for a complete sexual intercourse. For the achievement of the medication’s effect, sexual stimulation is needed.

Apomorphine, the active agent of the drug, is also used for Parkinson’s disease but in different formulations. If you need it for this health condition, please look at our Antiparkinsonian drugs category.

When is the use of Uprima contraindicated?

The medication is contraindicated in:

- Intolerance or allergy to the components of the tablets;

- Severe angina, recent myocardial infarction, severe heart failure or hypotension and other diseases in which sexual activity is contraindicated.

- The drug must not be used in women;

- Age under 18 years.

How is Uprima used?

When you buy Apomorphine sublingual tablets for erectile dysfunction, you can use it according to the following scheme:

Before the tablets use, it is recommended to drink a small amount of water for optimal dissolution of the tablet. One tablet of Uprima should be placed under the tongue about 20 minutes before sexual intercourse. In most patients, it completely dissolves within 10 minutes. If after 20 minutes the tablet remains in the mouth, it can be swallowed.

For the effective action of the medication, sexual stimulation is necessary. The patient is recommended to have sexual intercourse only when he feels that he is ready for it. The formulation’s effect begins about 18-19 minutes after placing the tablet under the tongue.

The first dosage recommended for all patients is 2 mg.

Subsequent doses: if necessary, the dose can be raised to 3 mg. It can be raised to a dosage sufficient for sexual intercourse up to 6 mg. The next dose can be taken no earlier than 8 hours after the previous one.

Dosage adjustments

- Men with moderate to severe kidney failure should use the medication only in dosage of 2 mg.

- For men with liver failure dosage adjustments are not needed.

What adverse effects can Uprima cause?

When you buy generic Apomorphine, you can develop certain adverse effects. Usually they are mild and transient but can enhance if high dosages are used.

The following adverse reactions are possible:

- A vegetative syndrome which occurs in a short spontaneously disappearing drop in blood pressure, which can lead to loss of consciousness/fainting (when using the drug in recommended doses, the reaction occurs in less than 0.2% of patients);

- Headache;

- Ache in different parts of the body;

- Flushing, reddening of the face.

- Nausea;

- Dizziness, sleepiness;

- Sore throat, runny nose, and cough;

- Sweating;

- Taste perversion.

Incidence of Adverse Reactions Occurring in Two or More Uprima-Treated Patients

Adverse reaction
Uprima
(n = 20)%
PLACEBO
(n = 9)%
Yawning
40
0
Dyskinesias
35
11
Drowsiness or Somnolence
35
0
Nausea and/or Vomiting
30
11
Dizziness or Postural Hypotension
20
0
Rhinorrhea
20
0
Chest Pain/Pressure/Angina
15
11
Hallucination or Confusion
10
0
Edema/Swelling of Extremities
10
0

Can Uprima be taken with other medicines?

- When taken with blood tension medications, Uprima’s adverse effects on the cardiovascular system can enhance and result in significant drop of arterial tension.

- The medication must not be used with agonists or antagonists of dopamine receptors of central action.

- The consumption of alcohol when using Uprima can result in sharp drop of arterial tension. Besides, it can cause the lowering of the medication’s effect.

Overdose

When using high doses of the medication it can cause vomiting. It is recommended that vital parameters such as blood pressure and heart rate be monitored. It is necessary to take measures to prevent possible orthostatic hypotension. It is advisable to consider the use of dopamine receptor antagonists.

Special recommendations for Uprima use

- The medication can cause spontaneous drop of arterial tension. It can cause fainting. This reaction occurs in less than 0.2% of individuals who use the medication in the recommended dosages. But it is advised to exert caution if you order Uprima and use it for the first time or raise the dosage. This symptoms can occur only at the first dosage intake or in the raise of the dosage and it doesn’t repeat in the intake of the following dosages. In the case of the following symptoms as nausea, vomiting, paleness, sweating, flushing, and/or dizziness, you should lie down and lift your legs up, remain in this position till the symptoms disappear.

- The medication must be used cautiously by people with uncontrolled hypertension, a known history of hypotension or postural hypotension. After sublingual administration of the drug, cases of a sudden decrease in blood pressure were sometimes observed. Older people may be more prone to such manifestations and sensitive to the adverse effects of such a reaction.

- Due to the possibility of sharp drop of blood tension, the formulation must be cautiously used by people who use blood tension lowering medications or nitrates.

- The medication must be cautiously used in kidney and/or liver dysfunction.

- Mediations for erection enhancement must be cautiously used by people with anatomic abnormalities of the penis, for instance in curvature, cavernous fibrosis or Peyronie’s disease).

- The safety of the medication’s combination with other erectile dysfunction drugs hadn’t been studied so their combined use is not recommended.

- Since some patients may experience dizziness or, in rare cases, fainting, it is not recommended to engage in activities requiring a quick reaction (for instance, driving) for at least the first 2 hours after taking Uprima or until such symptoms completely disappear.

Where can you buy Uprima?

We offer you to order generic Uprima at a low price and without a prescription. You can additionally save on shipping if you order pills for months ahead or buy other medications and the total sum of your order is over $170. In this case, we will ship the medication for free.

Free prescription
Our doctor prescribes online for free, and there is no doctor’s consultation fee.

Discrete packaging
All orders arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section

 

 
 
   
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